New human colorectal carcinoma cell lines that secrete proteinase inhibitors in vitro

Concomitant expression of hepatocyte growth factor (HGF), HGF activator and c‐met genes in human glioma cells in vitro

“…A human pancreas adenocarcinoma cell line SUIT-2 [19] was kindly provided by Dr. T. Iwamura, First Department of Surgery, Miyazaki Medical College, Japan. A human rectal adenocarcinoma cell line, RCM-1, was established in our laboratory [20]. Conditioned media were harvested from the confluent cultures after 24 h cultivation.…”

An evaluation of the prognostic significance of alpha-1-antitrypsin expression in adenocarcinomas of the lung: an immunohistochemical analysis

“…AAT is expressed not only in normal livers but also in other normal tissues such as the lung, gall bladder, pancreas, and the gastrointestinal tract (Tuttle & Jones, 1975;Ray et al, 1978;Kittas et al, 1982a;Geboes et al, 1982;Tahara et al, 1984;Aroni et al, 1984). Moreover, AAT has also been demonstrated in several neoplasms including carcinomas, mesenchymal tumours, hemopoietic and brain tumours (Reintoft & Hargerstrand, 1979;Kittas et al, 1982b;Glasgow et al, 1982;Aroni et al, 1984;Tahara et al, 1984;Krugliak et al, 1986;Wittekind et al, 1986;Sawaya et al, 1987;Soini & Miettinen, 1989;Kataoka et al, 1989;Perlmutter et al, 1989;Karashima et al, 1990). The presence of AAT in tumour cells is now considered to be due to its production by tumour cells themselves (Glasgow et al, 1982;Perlmutter et al, 1989;Kataoka et al, 1989).…”

“…Moreover, AAT has also been demonstrated in several neoplasms including carcinomas, mesenchymal tumours, hemopoietic and brain tumours (Reintoft & Hargerstrand, 1979;Kittas et al, 1982b;Glasgow et al, 1982;Aroni et al, 1984;Tahara et al, 1984;Krugliak et al, 1986;Wittekind et al, 1986;Sawaya et al, 1987;Soini & Miettinen, 1989;Kataoka et al, 1989;Perlmutter et al, 1989;Karashima et al, 1990). The presence of AAT in tumour cells is now considered to be due to its production by tumour cells themselves (Glasgow et al, 1982;Perlmutter et al, 1989;Kataoka et al, 1989). However, its significance in neoplastic tissues remains unknown.…”

Identification of Potential Tumor Markers in Sudanese Breast Cancer Patients Using a Proteomic Approach

“…It is present at significant levels in blood and at lower levels in other extra-cellular fluids, including breast milk [11]. Several cultured human tumor cell lines have been shown to produce functionally active α1-AT including the breast cancer cell line MCF7 [12]. Elevated immuno-staining of α1AT has also been described in various tumors, including tumors of the breast [13,14].…”