New Horizons of Synthetic Lethality in Cancer: Current Development and Future Perspectives
Viola Previtali,
Greta Bagnolini,
Andrea Ciamarone
et al.
Abstract:In recent years, synthetic lethality has been recognized as a solid paradigm for anticancer therapies. The discovery of a growing number of synthetic lethal targets has led to a significant expansion in the use of synthetic lethality, far beyond poly(ADPribose) polymerase inhibitors used to treat BRCA1/2-defective tumors. In particular, molecular targets within DNA damage response have provided a source of inhibitors that have rapidly reached clinical trials. This Perspective focuses on the most recent progres… Show more
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