New horizons in life extension, healthspan extension and exceptional longevity

Couteur, David G. Le; Barzilai, Nir

doi:10.1093/ageing/afac156

Cited by 24 publications

(17 citation statements)

References 45 publications

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“…Despite this, research into agerelated diseases aimed at slowing, halting and even reversing the aging process has not stopped, and extending the healthy lifespan of humans remains the focus of anti-aging research. 28,29 Researchers have been trying to find out which molecules and mechanisms are involved in the ageing process so that more corresponding drugs and sensible dietary supplements can be produced. Senescence of senescent cells or telomere attrition is an important cause of senescence, and therefore, anti-aging strategies by scavenging senescent cells and reducing the attrition of telomeres are also potential pharmacological strategies.…”

Section: Aging and Anti-aging Therapymentioning

confidence: 99%

Targeting AMPK signaling by polyphenols: a novel strategy for tackling aging

Luo

Huang

et al. 2023

Food Funct.

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Section: Aging and Anti-aging Therapymentioning

confidence: 99%

Targeting AMPK signaling by polyphenols: a novel strategy for tackling aging

Luo

Huang

et al. 2023

Food Funct.

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“…For this study, the primary challenge facing to us is how to measure the accelerated aging effect. The most common clinical outcomes in current anti-aging clinical studies mainly include age-related diseases and aging-related biomarkers (54,55). Distinguishing from chronological age, biological age as a biomarker of aging is a promising surrogate endpoint for anti-aging therapies in clinical research, such as KDM BioAge and PhenoAge (56,57).…”

Section: Discussionmentioning

confidence: 99%

Effect of dietary inflammatory potential on the aging acceleration for cardiometabolic disease: A population-based study

Wang

Huan

et al. 2022

Front. Nutr.

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Background/AimOptimized dietary patterns have been considered an important determinant of delaying aging in cardiometabolic disease (CMD). Dietary pattern with high-level dietary inflammatory potential is a key risk factor for cardiometabolic disease, and has drawn increasing attention. The aim of this study was to investigate whether dietary pattern with high dietary inflammatory potential was associated with aging acceleration in cardiometabolic disease.Materials and methodsWe analyzed the cross-sectional data from six survey cycles (1999–2000, 2001–2002, 2003–2004, 2005–2006, 2007–2008, and 2009–2010) of the National Health and Nutritional Examination Surveys (NHANES). A total of 16,681 non-institutionalized adults and non-pregnant females with CMD were included in this study. Dietary inflammatory index (DII) was used to assess the dietary inflammatory potential. The two age acceleration biomarkers were calculated by the residuals from regressing chronologic age on Klemera-Doubal method biological age (KDM BioAge) or Phenotypic Age (PhenoAge), termed “KDMAccel” and “PhenoAgeAccel.” A multivariable linear regression accounting for multistage survey design and sampling weights was used in different models to investigate the association between DII and aging acceleration. Four sensitivity analyses were used to ensure the robustness of our results. Besides, we also analyzed the anti-aging effects of DASH-type dietary pattern and “Life’s Simple 7”.ResultsFor 16,681 participants with CMD, compared with the first tertile of DII after adjusting for all potential confounders, the patients with second tertile of DII showed a 1.02-years increase in KDMAccel and 0.63-years increase in PhenoAgeAccel (KDMAccel, β = 1.02, 95% CI = 0.64 to 1.41, P < 0.001; PhenoAgeAccel, β = 0.63, 95% CI = 0.44 to 0.82, P < 0.001), while the patients with the third tertile of DII showed a 1.48-years increase in KDMAccel and 1.22-years increase in PhenoAgeAccel (KDMAccel, β = 1.48, 95% CI = 1.02 to 1.94, P < 0.001; PhenoAgeAccel, β = 1.22, 95% CI = 1.01 to 1.43, P < 0.001). In addition, DASH-type dietary pattern was associated with a 0.57-years reduction in KDMAccel (β = −0.57, 95% CI = −1.08 to −0.06, P = 0.031) and a 0.54-years reduction in PhenoAgeAccel (β = −0.54, 95% CI = −0.80 to −0.28, P < 0.001). The each one-unit increase in CVH score was associated with a 1.58-years decrease in KDMAccel (β = −1.58, 95% CI = −1.68 to −1.49, P < 0.001) and a 0.36-years in PhenoAgeAccel (β = −0.36, 95% CI = −0.41 to −0.31, P < 0.001).ConclusionAmong CMD, the dietary pattern with high dietary inflammatory potential was association with aging acceleration, and the anti-aging potential of DASH-type dietary pattern and “Life’s Simple 7” should also be given attention, but these observations require future prospective validation.

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“…As we are seeing with research on the biology of ageing (geroscience 2 ), age-related chronic diseases are not inevitable or untreatable; there are common pathways, defined by the hallmarks of ageing, 3 including cell senescence and systemic chronic inflammation, that lead to multiple morbidities. These pathways can now be manipulated with drugs and other interventions 4 early in the disease process, with promising data emerging from early human clinical trials. 5 We need to take a multipronged whole-of-life approach to tackle all the different, but interacting, drivers of health and disease.…”

Section: Quantum Healthy Longevity For Healthy People Planet and Growthmentioning

confidence: 99%