New Horizons for Assessment of Vitamin D Status in Man

Lensmeyer, Gary L.; Binkley, Neil; Drezner, Marc K.

doi:10.1016/b9-78-012088-5/62650-0327

Cited by 8 publications

(8 citation statements)

References 86 publications

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“…However, even using the RIA, 25% of this population would be classified as having low vitamin D status. Finally, although these assays were highly correlated, greater scatter at higher 25(OH)D values was observed with the RIA, as has been previously reported (18). This greater scatter at higher values slightly increases the mean bias noted previously; however, even when limiting the analysis to the 47 individ-…”

Section: Serum 25(oh)d and Pthmentioning

confidence: 51%

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Low Vitamin D Status despite Abundant Sun Exposure

Binkley¹,

Novotny

Krueger³

et al. 2007

The Journal of Clinical Endocrinology &Amp; Metabolism

396

248

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Section: Serum 25(oh)d and Pthmentioning

confidence: 51%

“…However, the goal for such therapy is unclear and could include achieving a serum 25(OH)D level greater than an accepted cutpoint (e.g. 30 ng/ml) or, alternatively, the upper limit of normal, a value that varies between laboratories (18).…”

Section: Ow Vitamin D Statusmentioning

confidence: 99%

Low Vitamin D Status despite Abundant Sun Exposure

Binkley¹,

Novotny

Krueger³

et al. 2007

The Journal of Clinical Endocrinology &Amp; Metabolism

396

248

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“…The assignment of a consistent serum vitamin D25(OH) level across laboratories is lacking but typically ranges from 10 to 20 ng/mL (10). At levels .20 ng/mL, insufficiency is not recognized by many institutional laboratories, including the one used in this study (11); rather, these levels are considered in the normal range (10)(11)(12). Recently, an international consensus panel established that 20 ng/mL is the minimum therapeutic level of serum vitamin D25(OH) but fell short of recommending the higher level of 32 ng/mL (9).…”

Section: Introductionmentioning

confidence: 99%

“…Percentages of subtherapeutic (,32 ng/mL) (13), insufficient (,20 ng/mL), and deficient (,13 ng/mL) levels are given in consecutive rows to emphasize the relative severities of low levels of vitamin D (4)(5)(6)(7)10). Because calcium absorption is reduced at levels of vitamin D previously considered therapeutic (4,5,14), all patients with values of serum D25(OH) ,32 ng/mL are at risk for bone loss.…”

Section: Description Of the Final Samplementioning

confidence: 99%

“…The starting level of insufficiency for serum vitamin D25(OH) is a point of contention in the literature (5)(6)(7)(8)(9). The assignment of a consistent serum vitamin D25(OH) level across laboratories is lacking but typically ranges from 10 to 20 ng/mL (10). At levels .20 ng/mL, insufficiency is not recognized by many institutional laboratories, including the one used in this study (11); rather, these levels are considered in the normal range (10)(11)(12).…”

Section: Introductionmentioning

confidence: 99%

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Influence of Season, Ethnicity, and Chronicity on Vitamin D Deficiency in Traumatic Spinal Cord Injury

Oleson

Patel

Wuermser

2010

The Journal of Spinal Cord Medicine

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Background: Inadequate levels of vitamin D increase the risk of osteoporosis, a highly prevalent condition in patients with traumatic spinal cord injury (SCI). Reduced sunlight and dark skin further contribute to low vitamin D levels. Objectives: To compare serum 25-hydroxy vitamin D [vitamin D25(OH)] levels in acute and chronic SCI and to explore seasonal and ethnic differences among patients with acute and chronic SCI. Patients/Methods: Patients (N 5 96) aged 19 to 55 years with C3-T10 motor complete SCI participated. Acute SCI was 2 to 6 months after injury, whereas chronic SCI was at least 1 year from injury. Serum vitamin D25(OH), calcium, and parathyroid hormone were drawn during summer or winter months. Vitamin D deficiency (,13 ng/mL), insufficiency (,20 ng/mL), and subtherapeutic (,32 ng/mL) levels were compared for all groups. A 3-way analysis of covariance was adopted to determine significant main effects of season, chronicity, and ethnicity. Interactions between season and chronicity, season and ethnicity, and chronicity and ethnicity were evaluated. Evaluation of a 3-way interaction among season, chronicity, and ethnicity was completed. Results: In summer, 65% of patients with acute SCI and 81% of patients with chronic SCI had subtherapeutic vitamin D levels, whereas in winter, 84% with acute SCI and 96% with chronic SCI had vitamin D25(OH) (,32ng/mL). Lower vitamin D25(OH) levels were observed in African Americans relative to whites. Significant main effects were noted for season (P 5 0.017), chronicity (P 5 0.003), and ethnicity (P , 0.001). However, interactions between 2 or more factors were not found. Conclusions: Vitamin D insufficiency and deficiency are found in the majority of patients with chronic SCI and in many with acute SCI. Initial screening for serum vitamin D25(OH) levels should be performed early in rehabilitation. Periodic monitoring in the chronic setting is highly recommended.

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Vitamin D Deficiency and Its Health Consequences in Africa

Prentice

Schoenmakers

Jones

et al. 2009

Clinic Rev Bone Miner Metab

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Africa is heterogeneous in latitude, geography, climate, food availability, religious and cultural practices, and skin pigmentation. It is expected, therefore, that prevalence of vitamin D deficiency varies widely, in line with influences on skin exposure to UVB sunshine. Furthermore, low calcium intakes and heavy burden of infectious disease common in many countries may increase vitamin D utilization and turnover. Studies of plasma 25OHD concentration indicate a spectrum from clinical deficiency to values at the high end of the physiological range; however, data are limited. Representative studies of status in different countries, using comparable analytical techniques, and of relationships between vitamin D status and risk of infectious and chronic diseases relevant to the African context are needed. Public health measures to secure vitamin D adequacy cannot encompass the whole continent and need to be developed locally.

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New Horizons for Assessment of Vitamin D Status in Man

Cited by 8 publications

References 86 publications

Low Vitamin D Status despite Abundant Sun Exposure

Low Vitamin D Status despite Abundant Sun Exposure

Influence of Season, Ethnicity, and Chronicity on Vitamin D Deficiency in Traumatic Spinal Cord Injury

Vitamin D Deficiency and Its Health Consequences in Africa

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