New Heterocyclic Compounds from 1,2,4-triazoles Class with Potential Cytotoxic Activity

Abstract

Acylhydrazinecarbothioamides (2a,b) were synthesized by addition of 2-(5H-dibenzo[a,d][7]annulen-5-yl)acetohydrazide to different isothiocyanates. The new 1,2,4-triazol-3-thioles (3a,b) were synthesized by cyclization of new 2- acylhydrazinecarbothioamides (3a,b) in basic media. Alkylation of 1,2,4-triazole-3-thiols (3a-c) with ethyl bromide gave only S-substituted derivatives (4a-c). The structures of the synthesized compounds have been established on spectral data (IR, 1H-NMR and 13C-NMR spectroscopy) and elemental analysis. The cytotoxic effect of new compounds was evaluated using two alternative models on plant and invertebrate organisms.

Synthesis, Characterization and Toxicity Evaluation of Cu(II), Mn(II), Co(II), Ni(II), Pd(II) Complexes with Ligand Derived from Hydrazinecarbothioamide

“…The complexes were studied by thermogravimetry (TG) in static air atmosphere, with a sample heating rate of 10 o C/ min using a STA 6000 Perkin Elmer. D. magna bioassay was performed using the method described by Socea et al with some modifications [9,16]. The determination was performed in 4 mL 12-tissue culture wells (Greiner Bio-One), using 10 daphnids/well and each sample was tested in duplicate.…”

“…The hydrazinecarbothioamide derivatives were found to exhibit antimicrobial, antifungal, tuberculostatic, cytostatic, anticonvulsant, antiviral, and antioxidant and anti-inflammatory, antihypertensive activities [6][7][8][9]. In last years a wide variety of heterocyclic systems and hydrazinecarbothioamides have been explored for developing the new antimicrobial agents [4,5].…”

New N-acylhydrazones with Potential Cytotoxic Activity

“…The newly compounds were tested for potential cytotoxicity using an alternative methods on invertebrate organisms, Daphnia magna. This test is rapid, simple and cost-efficiently and can predict biological activities such as anticancer and analgesic activities [11,[18][19][20][21][22][23].…”

Synthesis, characterization and Cytotoxicity Evaluation of New Heterocyclic Compounds with Oxazole Ring Containing 4-(Phenylsulfonyl)phenyl Moiety

“…For this purpose, the novel synthesized compounds were tested for cytotoxic activity using Daphnia magna bioassay. Among other alternative screening assays, this method is simple, rapid, and can predict the biological effect [34][35][36][37][38][39][40][41].…”