New halogenated phenylcoumarins as tyrosinase inhibitors

Synthesis and adenosine receptors binding affinities of a series of 3-arylcoumarins

“…Coumarins are an important class of benzopyrone heterocyclic compounds, of natural or synthetic origin, associated with remarkable pharmacological activity . Diverse biological properties, such as antioxidant, anti‐HIV, anticancer, anti‐inflammatory, antimicrobial, vasorelaxant or enzymatic inhibitory agents, have been ascribed to this type of structure . The fused heterocyclic framework of coumarins has been widely used as an archetype for the synthesis of a wide variety of analogues suitable to perform structure–activity relationship (SAR) studies intended to improve their biological properties .…”

Tyrosine-like condensed derivatives as tyrosinase inhibitors

“…In this context, and in an attempt to develop novel tyrosinase inhibitors, we had previously synthesized and described 3-arylcoumarin derivatives in which both the coumarin and the resveratrol templates were present. [23,27] Based on this work, and with the aim of finding new structure-activity features, we propose the study of a series of tyrosine-like condensed molecules ( Figure 1). The similarity of these compounds to the tyrosinase substrate is the novelty of this study.…”

Synthesis and electrochemical study of new 3-(hydroxyphenyl)benzo[f]coumarins

“…Perkin condensation [19,33,[37][38][39][40][41] were synthesized starting from the respective methoxy derivatives 1-5 by hydrolysis reaction, using hydriodic acid 57%.…”

“…Coumarins are also described as antiviral, vasorelaxant, antioxidant, antimicrobial, anticancer, anti-inflammatory and enzymatic inhibitors [22][23][24][25][26][27][28][29][30][31][32][33], but limited data is available concerning their antioxidant activity [22,30,[34][35][36].…”