New Halogenated Flavonoids from Adenosma bracteosum and Vitex negundo and Their α‐Glucosidase Inhibition

Abstract

Adenosma bracteosum and Vitex negundo are natural sources of methoxylated flavonoids. Little is known about the α-glucosidase inhibition of multi-methoxylated flavonoid derivatives. Eighteen natural flavonoids were isolated from A. bracteosum and V. negundo. Seven halogenated derivatives were synthesized. Their chemical structures were elucidated by extensive NMR analysis and high-resolution mass spectroscopy as well as comparisons in literature. All compounds were evaluated for their α-glucosidase inhibition. Most compounds showed good activity with IC 50 values ranging from 16.7 to 421.8 μM. 6,8-Dibromocatechin was the most active compound with an IC 50 value of 16.7 μM. A molecular docking study was conducted, indicating that those compounds are potent α-glucosidase inhibitors.

Bioactive-Guided Phytochemical Investigations, In Vitro and In Silico Alpha-Glucosidase Inhibition of Two Vietnamese Medicinal Plants Dicranopteris linearis and Psychotria adenophylla

“…Multi-oxygenated flavonoids DL8 and DL9 are less potent than the above-mentioned flavonoids. Their low inhibition might be affected by the presence of the 3-oMe group, which was reported previously by Nguyen et al, 2023 [ 53 ].…”

Bio-guided isolation of alpha-glucosidase inhibitory compounds from Vietnamese liverwort Marchantia polymorpha: in vitro and in silico studies

“…Alpha-glucosidase inhibition of compounds 13–15 was previously evaluated in many published reports. 37 Among the tested compounds, bis-bibenzyl-type compounds 1–4 showed better inhibition. The main difference between 1–4 is in the linkage between C- and D-rings ( Fig.…”

“…Evaluation of the inhibitory activity of 1–12 against yeast alpha-glucosidase followed a previous procedure. 37 …”