New graft copolymers of hyaluronic acid and polylactic acid: Synthesis and characterization

Palumbo, Fabio Salvatore; Pitarresi, Giovanna; Mandracchia, Delia; Tripodo, Giuseppe; Giammona, Gaetano

doi:10.1016/j.carbpol.2006.03.023

Cited by 110 publications

(64 citation statements)

References 14 publications

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“…Cross-linked networks of synthetic polymers such as polyethylene oxide (PEO) (Khoylou & Naimian, 2009), polyvinyl pyrollidone (PVP) (Razzak et al, 2001), polylactic acid (PLA) (Palumbo et al, 2006), , polyacrylic acid (PAA) (Onuki et al, 2008), polymethacrylate (PMA) (Yang et al), polyethylene glycol (PEG) (Singh et al), or natural biopolymers (Coviello et al, 2007) such as alginate, chitosan, carrageenan, hyaluronan, and carboxymethyl cellulose (CMC) have been reported. The various preparation techniques adopted are physical crosslinking (Hennink & Nostrum, 2002), chemical cross-linking (Barbucci et al, 2004), grafting polymerisation (Said et al, 2004), and radiation cross-linking (Fei et al, 2000;Liu et al, 2002b).…”

Section: Methods To Produce Hydrogelmentioning

confidence: 99%

Hydrogels: Methods of Preparation, Characterisation and Applications

Gulrez¹,

Al-Assaf²,

Phillips³

2011

Progress in Molecular and Environmental Bioengineering - From Analysis and Modeling to Technology Applications

223

178

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Section: Methods To Produce Hydrogelmentioning

confidence: 99%

Hydrogels: Methods of Preparation, Characterisation and Applications

Gulrez¹,

Al-Assaf²,

Phillips³

2011

Progress in Molecular and Environmental Bioengineering - From Analysis and Modeling to Technology Applications

223

178

View full text Add to dashboard Cite

“…The combination of HA with synthetic polymers, such as polylactic/polyglycolic acids was intended to improve the poor biological properties of the latter [55,56]. Mixtures of HA with hydroxyapatite and calcium phosphate ceramics for developing composite biomaterials [57][58][59][60][61] resulted in prolonged scaffold stability and reduced degradation rates, but the composite exhibited impaired biological activity.…”

Section: Immunohistochemical Stainingmentioning

confidence: 99%

Calcite Biohybrids as Microenvironment for Stem Cells

2012

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Abstract:A new type of composite 3D biomaterial that provides extracellular cues that govern the differentiation processes of mesenchymal stem cells (MSCs) has been developed. In the present study, we evaluated the chondrogenecity of a biohybrid composed of a calcium carbonate scaffold in its calcite polymorph and hyaluronic acid (HA). The source of the calcite scaffolding is an exoskeleton of a sea barnacle Tetraclita rifotincta (T. rifotincta), Pilsbry (1916). The combination of a calcium carbonate-based bioactive scaffold with a natural polymeric hydrogel is designed to mimic the organic-mineral composite of developing bone by providing a fine-tuned microenvironment. The results indicate that the calcite-HA interface creates a suitable microenvironment for the chondrogenic differentiation of MSCs, and therefore, the biohybrid may provide a tool for tissue-engineered cartilage.

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“…It is water soluble and exhibits high hydroxyl functional groups available for common coupling reactions [24]. Various studies have dealt with its chemical modification in order to obtain biocompatible drug delivery systems (DDS), including hydrogels [25], nanoparticles [26], micelles [6] and [27], and macromolecular bioconjugates [28]. Being inulin versatile and highly functionalizable [29] and [30], here we focused our attention on the synthesis of an amphiphilic inulin derivative capable of coating SPIONs once placed in aqueous media.…”

Section: Introductionmentioning

confidence: 99%

Inulin-based polymer coated SPIONs as potential drug delivery systems for targeted cancer therapy

Scialabba

Licciardi

Mauro

et al. 2014

European Journal of Pharmaceutics and Biopharmaceutics

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This paper deal with the synthesis and characterization of PEGylated squalene-grafted-inulin amphiphile capable of self-assembling and self-organizing into nanocarriers once placed in aqueous media. It was exploited as coating agent for obtaining doxorubicin loaded superparamagnetic iron oxide nanoparticles (SPIONs) endowed with stealth like behavior and excellent physicochemical stability. Inulin was firstly modified in the side chain with primary amine groups, followed in turn by conjugation with squalenoyl derivatives through common amidic coupling agents and PEGylation by imine linkage. Polymer coated SPIONs were so obtained by spontaneous self-assembling of inulin copolymer onto magnetite surface involving hydrophobic-hydrophobic interactions between the metallic core and the squalene moieties. The system was characterized in terms of hydrodynamic radius, zeta potential, shape and drug loading capacity. On the whole, the stealth-like shell stabilized the suspension in aqueous media, though allowing the release of the doxorubicin loaded in therapeutic range. The cytotoxicity profile on cancer (HCT116) cell line and in vitro drug uptake were evaluated both with and without an external magnetic field used as targeting agent and uptake promoter, displaying that magnetic targeting implies advantageous therapeutic effects, that is amplified drug uptake and increased anticancer activity throughout the tumor mass.

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New graft copolymers of hyaluronic acid and polylactic acid: Synthesis and characterization

Cited by 110 publications

References 14 publications

Hydrogels: Methods of Preparation, Characterisation and Applications

Hydrogels: Methods of Preparation, Characterisation and Applications

Calcite Biohybrids as Microenvironment for Stem Cells

Inulin-based polymer coated SPIONs as potential drug delivery systems for targeted cancer therapy

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