New Glycosalen–Manganese(III) Complexes and RCA120 Hybrid Systems as Superoxide Dismutase/Catalase Mimetics

Lanza, Valeria; Vecchio, Graziella

doi:10.3390/biomimetics8050447

Cited by 3 publications

(2 citation statements)

References 62 publications

(91 reference statements)

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“…In an in vivo experiment, EUK-8 significantly reduced the phosphorylation level of several inflammatory proteins such as p38 member of MAPK pathway, protein kinase B (Akt), and transcription factor p65, and inhibited pro-inflammatory cytokine interleukin-6 and chemokine CXCL1 ( Jayachandra et al, 2023 ). A recent study reported a synthesis of new glycosalen-Mn(III) complexes of EUK-108 with glucose and galactose ( Lanza and Vecchio, 2023 ). These complexes showed both SOD- and CAT-like activities and could be advantageous for future clinical applications.…”

Section: Antioxidants That Potentially Can Be Used For the Developmen...mentioning

confidence: 99%

Potential use of antioxidants for the treatment of chronic inflammatory diseases

Blagov,

Summerhill,

Sukhorukov

et al. 2024

Front. Pharmacol.

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The excessive production of various reactive oxidant species over endogenous antioxidant defense mechanisms leads to the development of a state of oxidative stress, with serious biological consequences. The consequences of oxidative stress depend on the balance between the generation of reactive oxidant species and the antioxidant defense and include oxidative damage of biomolecules, disruption of signal transduction, mutation, and cell apoptosis. Accumulating evidence suggests that oxidative stress is involved in the physiopathology of various debilitating illnesses associated with chronic inflammation, including cardiovascular diseases, diabetes, cancer, or neurodegenerative processes, that need continuous pharmacological treatment. Oxidative stress and chronic inflammation are tightly linked pathophysiological processes, one of which can be simply promoted by another. Although, many antioxidant trials have been unsuccessful (some of the trials showed either no effect or even harmful effects) in human patients as a preventive or curative measure, targeting oxidative stress remains an interesting therapeutic approach for the development of new agents to design novel anti-inflammatory drugs with a reliable safety profile. In this regard, several natural antioxidant compounds were explored as potential therapeutic options for the treatment of chronic inflammatory diseases. Several metalloenzymes, such as superoxide dismutase, catalase, and glutathione peroxidase, are among the essential enzymes that maintain the low nanomolar physiological concentrations of superoxide (O2•−) and hydrogen peroxide (H2O2), the major redox signaling molecules, and thus play important roles in the alteration of the redox homeostasis. These enzymes have become a striking source of motivation to design catalytic drugs to enhance the action of these enzymes under pathological conditions related to chronic inflammation. This review is focused on several major representatives of natural and synthetic antioxidants as potential drug candidates for the treatment of chronic inflammatory diseases.

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Section: Antioxidants That Potentially Can Be Used For the Developmen...mentioning

confidence: 99%

Potential use of antioxidants for the treatment of chronic inflammatory diseases

Blagov,

Summerhill,

Sukhorukov

et al. 2024

Front. Pharmacol.

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“…Manganosalen complexes are a class of synthetic catalysts with antioxidant capacity [ 1 , 2 , 3 , 4 , 5 ]. Their design is inspired by natural enzymes such as catalases, superoxide dismutases, or glutathione peroxidases, which are all part of the body’s antioxidant barrier that controls the excess of reactive oxygen species (ROS) [ 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

Understanding the Factors That Influence the Antioxidant Activity of Manganosalen Complexes with Neuroprotective Effects

Rouco,

Alvariño,

Alfonso

et al. 2024

Antioxidants

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Manganosalen complexes are a class of catalytic antioxidants with beneficial effects against different neurological disorders according to various in vitro and in vivo studies. The interest in the factors that determine their antioxidant activity is based on the fact that they are key to achieving more efficient models. In this work, we report a set of new manganosalen complexes, thoroughly characterized in the solid state and in solution by different techniques. The chelating Schiff base ligands used were prepared from condensation of different substituted hydroxybenzaldehydes with 1,2-diaminoethane and 1,3-diaminopropane. The antioxidant activity of the new models was tested through superoxide dismutase and catalase probes in conjunction with the studies about their neuroprotective effects in human SH-SY5Y neuroblastoma cells in an oxidative stress model. The ability to scavenge excess reactive oxygen species (ROS) varied depending on the manganosalen models, which also yielded different improvements in cell survival. An assessment of the different factors that affect the oxidant activity for these complexes, and others previously reported, revealed the major influence of the structural factors versus the redox properties of the manganosalen complexes.

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Synthesis, characterization, thermal, theoretical studies, antimicrobial, antioxidant activity, superoxide dismutase-like activity and catalase mimetics of metal(II) complexes derived from sugar and Schiff base

Bufarwa,

El-Seifat,

Binhamad

et al. 2024

Reviews in Inorganic Chemistry

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Scientists are searching for reactive oxygen species, which have been associated with various health issues like heart problems, neurological disorders, inflammation, and aging. Salen complexes have proven to be effective in multiple oxidative stress situations and have been used as catalase and superoxide mimetics. To explore this further, three mixed complexes were synthesized using a Schiff base (salen) and a sugar (d-glucose) with Co(II), Ni(II), and Cu(II) ions. These complexes were then diagnosed by different analytical and spectral techniques. Stoichiometry, stereochemistry, some physical properties, and the method of bonding complexes were measured. Comparisons of the IR and 1HNMR spectra of the ligands with the complexes demonstrated the involvement of the azomethine group of the ligand in the chelation process. The mass spectra and TGA agree with the proposed formula of the complexes, and the conductivity and UV–Vis data supported the octahedral geometry of the complexes, and information was obtained from partial parameter calculations by molecular modeling. The metal complexes exhibited strong antimicrobial and antioxidant properties when compared to standard drugs. The like-superoxide and catalyst mimetic complexes were screened using DPPH ABTS, revealing their effectiveness.

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New Glycosalen–Manganese(III) Complexes and RCA120 Hybrid Systems as Superoxide Dismutase/Catalase Mimetics

Cited by 3 publications

References 62 publications

Potential use of antioxidants for the treatment of chronic inflammatory diseases

Potential use of antioxidants for the treatment of chronic inflammatory diseases

Understanding the Factors That Influence the Antioxidant Activity of Manganosalen Complexes with Neuroprotective Effects

Synthesis, characterization, thermal, theoretical studies, antimicrobial, antioxidant activity, superoxide dismutase-like activity and catalase mimetics of metal(II) complexes derived from sugar and Schiff base

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