New glycopeptide antibiotics. I. The structures of orienticins.

Tsuji, Naoki; Kobayashi, Masaaki; Kamigauchi, Toshiyuki; Yoshimura, Y.; Terui, Yoshihiro

doi:10.7164/antibiotics.41.819

Cited by 35 publications

(24 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The remaining monochloro regioisomer (residue 6), Orienticin A, can be obtained from natural sources. [80][81][82] Catalytic hydrogenation of A82846B (5% Pd/BaSO 4 , 15 psi H 2 , 2 h) results in the selective removal of the residue 2 chloro substituent, affording a product identical to Orienticin A (Scheme 11). 83 Under more vigorous conditions (10% Pd/C, 4 atm H 2 , 4 days) hydrogenation of A82846B affords the di-dechloro derivative A82846C.…”

Section: In Vitromentioning

confidence: 98%

Structural modifications of glycopeptide antibiotics

Malabarba¹,

1997

View full text Add to dashboard Cite

Section: In Vitromentioning

confidence: 98%

Structural modifications of glycopeptide antibiotics

Malabarba¹,

1997

View full text Add to dashboard Cite

“…In the vancomycin-type antibiotics, naturally occurring amino acid 1 is leucine or its methylated analogs (6,11,14,21,23,25,34,35). The state of methylation of the N-terminal leucine does not greatly affect the antibacterial activity of vancomycin.…”

Section: Structure-activity Relationships (Sar)mentioning

confidence: 99%

“…Several close structural analogs of vancomycin have been reported recently, and these include A51568 factors A and B (14); the M43 group of antibiotics (25); A82846 factors A, B, and C (23); orienticins (35); chloroorienticins (34); eremomycin (6); and MM45289 (11).…”

Section: Structure-activity Relationships (Sar)mentioning

confidence: 99%

Antibacterial activities and modes of action of vancomycin and related glycopeptides

Ramakrishnan

1991

Antimicrob Agents Chemother

127

View full text Add to dashboard Cite

“…Amycolatopsis orientalis is widely known for producing a large number of secondary metabolites including a potent glycopeptide antibiotic vancomycin [4] along with other related antibiotics as chloroeremomycin, eremomycin [52] and orienticins [53] (Fig. 5).…”

Section: Amycolatopsis Orientalismentioning

confidence: 99%

Genetics and Genomics of the Genus Amycolatopsis

2016

View full text Add to dashboard Cite

Actinobacteria are gram-positive filamentous bacteria which contains some of the most deadly human pathogens (Mycobacterium tuberculosis, M. leprae, Corynebacterium diphtheriae, Nocardia farcinica), plant pathogens (Streptomyces scabies, Leifsonia xyli) along with organisms that produces antibiotic (Streptomycetes, Amycolatopsis, Salinospora). Interestingly, these bacteria are equipped with an extraordinary capability of producing antibiotics and other metabolites which have medicinal properties. With the advent of inexpensive genome sequencing techniques and their clinical importance, many genomes of Actinobacteria have been successfully sequenced. These days, with the constant increasing number of drug-resistant bacteria, the urgent need for discovering new antibiotics has emerged as a major scientific challenge. And, unfortunately the traditional method of screening bacterial strains for the production of antibiotics has decreased leading to a paradigm shift in the planning and execution of discovery of novel biosynthetic gene clusters via genome mining process. The entire focus has shifted to the evaluation of genetic capacity of organisms for metabolite production and activation of cryptic gene clusters. This has been made possible only due to the availability of genome sequencing and has been augmented by genomic studies and new biotechnological approaches. Through this article, we present the analysis of the genomes of species belonging to the genus Amycolatopsis, sequenced till date with a focus on completely sequenced genomes and their application for further studies.

show abstract

New glycopeptide antibiotics. I. The structures of orienticins.

Cited by 35 publications

References 4 publications

Structural modifications of glycopeptide antibiotics

Structural modifications of glycopeptide antibiotics

Antibacterial activities and modes of action of vancomycin and related glycopeptides

Genetics and Genomics of the Genus Amycolatopsis

Contact Info

Product

Resources

About