New generation prostate cancer therapy may impact motivation for exploration, spatial learning and dopaminergic transmission in aged castrated mice
Celeste Nicola,
Martine Dubois,
Cynthia Campart
et al.
Abstract:Background and Purpose: Cognitive side effects after cancer treatment
threatening quality of life (QoL) constitute a major challenge in
oncology. Abiraterone acetate plus prednisone (AAP) and enzalutamide
(ENZ) are next generation therapy (NGT) administered with androgen
deprivation therapy to metastatic castration-resistant prostate cancer
(mCRPC) patients. NGT significantly improved mCRPC overall survival but
neurological side effects such as fatigue and cognitive impairment have
been recently reported. Expe… Show more
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