New generation of chitosan-encapsulated ZnO quantum dots loaded with drug: Synthesis, characterization and in vitro drug delivery response

Yuan, Quan; Hein, San; Misra, R.D.K.

doi:10.1016/j.actbio.2010.01.025

Cited by 336 publications

(144 citation statements)

References 36 publications

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“…[14][15][16] Furthermore, the thiol-QD bond is also reported not to be very stable and precipitates readily on being dialyzed against buffer solution and water with time. 17,18 In addition to this finding, MPA, one of the common stabilizers used for the synthesis of water-soluble QDs, is a volatile liquid with strong odor and is reported to be carcinogenic in nature and environmentally unfriendly. Thus, the use and application of MPA as water-soluble stabilizer is not entirely green chemistry approach.…”

Section: Introductionmentioning

confidence: 99%

“…CS is highly biocompatible, nontoxic and environmentally friendly and helps to render QDs as water soluble. 4,17 In addition to these qualities, the large functional backbone of CS can equally serves as a viable platform for the encapsulation of drugs and other suitable ligands. 9,20 This unique signature of CS in addition to being a stabilizer and drug delivery vehicle, also protects the conjugated QDs and reduces the possibility of nonspecific protein opsonization.…”

Section: Introductionmentioning

confidence: 99%

“…9,20 This unique signature of CS in addition to being a stabilizer and drug delivery vehicle, also protects the conjugated QDs and reduces the possibility of nonspecific protein opsonization. 17,21 From a biomedical point of view, the Mn 2+ -doped ZnS (Mn:ZnS) conjugated CS nanocarrier can be made to achieve active or selective targeting and imaging of diseases by attaching suitable ligands with strong binding affinity toward the largely expressed receptors such as proteins, vitamins, monoclonal antibodies, aptamers, and peptides. 22,23 These among many have been reported in the development of a number of theranostic applications that included targeted drug delivery using receptor-mediated pathways for the detection of cancerous tumors or following protein-protein interactions toward the detection of proteins in blood assays.…”

Section: Introductionmentioning

confidence: 99%

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Folic acid targeted Mn:ZnS quantum dots for theranostic applications of cancer cell imaging and therapy

Bwatanglang¹,

Mohammad²,

Yusof³

et al. 2016

IJN

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In this study, we synthesized a multifunctional nanoparticulate system with specific targeting, imaging, and drug delivering functionalities by following a three-step protocol that operates at room temperature and solely in aqueous media. The synthesis involves the encapsulation of luminescent Mn:ZnS quantum dots (QDs) with chitosan not only as a stabilizer in biological environment, but also to further provide active binding sites for the conjugation of other biomolecules. Folic acid was incorporated as targeting agent for the specific targeting of the nanocarrier toward the cells overexpressing folate receptors. Thus, the formed composite emits orange–red fluorescence around 600 nm and investigated to the highest intensity at Mn 2+ doping concentration of 15 at.% and relatively more stable at low acidic and low alkaline pH levels. The structural characteristics and optical properties were thoroughly analyzed by using Fourier transform infrared, X-ray diffraction, dynamic light scattering, ultraviolet-visible, and fluorescence spectroscopy. Further characterization was conducted using thermogravimetric analysis, high-resolution transmission electron microscopy, field emission scanning electron microscopy, energy dispersive X-ray spectroscopy, X-ray fluorescence, and X-ray photoelectron spectroscopy. The cell viability and proliferation studies by means of MTT assay have demonstrated that the as-synthesized composites do not exhibit any toxicity toward the human breast cell line MCF-10 (noncancer) and the breast cancer cell lines (MCF-7 and MDA-MB-231) up to a 500 µg/mL concentration. The cellular uptake of the nanocomposites was assayed by confocal laser scanning microscope by taking advantage of the conjugated Mn:ZnS QDs as fluorescence makers. The result showed that the functionalization of the chitosan-encapsulated QDs with folic acid enhanced the internalization and binding affinity of the nanocarrier toward folate receptor-overexpressed cells. Therefore, we hypothesized that due to the nontoxic nature of the composite, the as-synthesized nanoparticulate system can be used as a promising candidate for theranostic applications, especially for a simultaneous targeted drug delivery and cellular imaging.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Folic acid targeted Mn:ZnS quantum dots for theranostic applications of cancer cell imaging and therapy

Bwatanglang¹,

Mohammad²,

Yusof³

et al. 2016

IJN

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“…Chitosn based nano compounds were found to be well adapted towards antimalarial drug delivery as a nanocarrier [14], as a promising drug delivery system to improve antiviral potency of drugs to the viral reservoirs for the treatment of HIV infection [15], modified by folic acid towards targeted drug delivery [16], development of responsive hybrid nanogels by poly(methacrylic acid) for pH responsive drug release [17], and magnetic chitosan nanoparticles, as multifunctional nanocarriers, were loaded with bleomycin as a functional nanocarrier have been proved to be effective towards targeting system [18].…”

Section: Chitosan Based Nano Towards Drug Delivery Systemmentioning

confidence: 99%

Chitosan Based Nanoparticles towards Biomedical Applications

Laskar¹,

Rauf²

2017

JNMR

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This review outlines the bioapplications of newly developed chitosan based nanoparticles. Over the last decade, much interest has been developed in biopolymer based materials due to their biocompatible, biodegradable, nontoxic and non-allergenic nature. Here, we review the recent scientific advances in chitosan based nanoparticles not only for cancer therapy but also for various biomedical applications. An overview of chitosan, its derivatives and the formation of chitosan nanoparticles is provided along with the inherent and specific therapeutic efficacy. Major progresses in drug delivery approaches and gene delivery as well as tissue engineering applications have been summarized.

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“…Among the various nanomaterials, ZnO has attracted more attention due to its wide band gap of (3.37 eV).It plays an important role in optics, optoelectronics, sensors, and actuators due to its semiconducting and piezoelectric properties 26 . Nanostructured ZnO possess high surface area, good chemical stability and nontoxic 27 . The bio synthesized ZnO nanoparticles are trusted to be friendly with the environment, bio safe and biocompatible 28 .…”

Section: Introductionmentioning

confidence: 99%

Environmentally Benign Solar degradation of Methylene Blue dye using Green synthesized ZnO Nanoparticle

2018

IJGHC

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New generation of chitosan-encapsulated ZnO quantum dots loaded with drug: Synthesis, characterization and in vitro drug delivery response

Cited by 336 publications

References 36 publications

Folic acid targeted Mn:ZnS quantum dots for theranostic applications of cancer cell imaging and therapy

Folic acid targeted Mn:ZnS quantum dots for theranostic applications of cancer cell imaging and therapy

Chitosan Based Nanoparticles towards Biomedical Applications

Environmentally Benign Solar degradation of Methylene Blue dye using Green synthesized ZnO Nanoparticle

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