New generation lipid emulsions increase brain DHA and improve body composition, but not short-term neurodevelopment in parenterally-fed preterm piglets

Molina, Tiffany L.; Stoll, Barbara J.; Mohammad, Mahmoud A.; Mohila, Carrie A.; Call, Lee; Cui, Liwei; Guthrie, Gregory; Kunichoff, Dennis; Lin, Sen; Welch-Jernigan, Rebecca; Nielsen, Janni; Premkumar, Muralidhar H.; Robinson, Jason L.; Smith, Victoria; Teets, Haley; Obelitz-Ryom, Karina; Hagan, Joseph; Cruz, Stephanie M.; Lau, Patricio E.; Puyau, Maurice R.; Shypailo, Roman J.; Manjarín, Rodrigo; Butte, Nancy F.; Fang, Zhengfeng; Olutoye, Oluyinka O.; Thymann, Thomas; Sangild, Per T.; Burrin, Douglas G.

doi:10.1016/j.bbi.2019.04.031

Cited by 12 publications

(11 citation statements)

References 24 publications

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“…The particle size of the human milk fat globules (average 4.52 μm) was significantly larger than of the infant formulas, and the particle size distributions were between 2.31 μm and 7.78 μm, which was consistent with the reports of Lopez et al and Fondaco et al [ 27 , 28 ]. Several studies have shown that the large particle size of human milk fat globules could help with lipid metabolism in infants [ 29 , 30 ].…”

Section: Resultsmentioning

confidence: 99%

“…The low concentration of fatty acids released from IF1 was likely related to its fat globules being covered by protein. Lipid droplets with this interface composition were prone to accumulate in large quantities in gastric digestion, which hindered complete hydrolysis in intestinal digestion [ 30 ]. The whole fat milk powder used in IF5 may be the cause of the low fatty acid release.…”

Section: Resultsmentioning

confidence: 99%

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A Comparative Analysis of Lipid Digestion in Human Milk and Infant Formulas Based on Simulated In Vitro Infant Gastrointestinal Digestion

Lin

et al. 2022

Foods

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To investigate the lipid digestive behaviors of human and infant formulas and analyze the differences between them, we investigated the fat globule particle size distribution, lipolysis rate, and fatty acid release of infant formulas with different fat sources and human milk using an in vitro infant digestion model. The results suggested that the particle size in infant formula increased rapidly during gastric digestion and decreased significantly after intestinal digestion, whereas the particle size in human milk increased slowly during gastric digestion but increased rapidly during intestinal digestion (p < 0.05). Despite having a larger droplet size, human milk demonstrated a very high lipolysis rate due to the presence of MFGM. In terms of the distribution of fatty acids in digestion products, the proportion of saturated fatty acids (SFAs), monounsaturated fatty acids (MUFAs), and polyunsaturated fatty acids (PUFAs) in vegetable oil-based infant formulas was close to that of human milk. The amount of SFAs in milk fat-based infant formulas was significantly higher than that in human milk, and the content of MUFAs in all infant formulas was significantly lower than that in human milk (p < 0.05). After digestion, the most abundant fatty acid released by human milk was C18:2n6c, while the fatty acids released by infant formulas were SFAs, such as C14:0, C16:0, and C18:0.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

A Comparative Analysis of Lipid Digestion in Human Milk and Infant Formulas Based on Simulated In Vitro Infant Gastrointestinal Digestion

Lin

et al. 2022

Foods

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“…Lipids used within the first two days of life of preterm babies are safe and well-tolerated, providing energy and essential fatty acids before full enteral feeding, which is necessary for central nervous system development [ 14 ]. In an animal study, parenterally administered lipid emulsions enriched with DHA and arachidonic acid resulted in increased cortical DHA and improved body composition without affecting short-term neurodevelopmental outcomes [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Smoflipid Is Better Than Lipofundin for Long-Term Neurodevelopmental Outcomes in Preterm Infants

2021

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Neurodevelopmental morbidities developed more commonly in low-birth-weight premature infants. We sought to determine the effects of different lipid emulsions on the neurodevelopmental outcomes of children born prematurely. This retrospective cross-sectional study had two intervention legs, Lipofundin® MCT/LCT (LIPO) versus Smoflipid® (SMOF), which are mainly differentiated by fish oil. Data of premature neonates born between 2001 and 2015 from the research database of Chang Gung Memorial Hospital with corresponding individual medical records up to July 2020 were analyzed. Long-term neurodevelopmental outcomes were defined by the international classification of disease codes −9 or −10. The prevalence of diseases was compared between LIPO and SMOF groups at five and five years old and further analyzed by stratification of 1500 g birth weight. The LIPO and SMOF groups each included 1120 neonates. Epilepsy, cerebral palsy, developmental disorder and attention-deficit hyperactivity disorder (ADHD) were significantly decreased at age two years in the SMOF group, and epilepsy, language delay (LD), ADHD and autism spectrum disorder (ASD) were significantly decreased in the SMOF group at age five years. In children with birth weight < 1500 g, ADHD was decreased in the SMOF group at ages two and five years, and ASD was decreased in the SMOF group at age five years. In children with birth weight ≥ 1500 g, epilepsy, LD and ADHD were decreased in the SMOF group at age two years. LD was decreased in the SMOF group at age five years. We conclude that lipid emulsions with fish oil improve the neurodevelopmental outcomes of children born prematurely.

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“…LC-PUFA are also essential for the development of the brain, retina, and central nervous system. However, it has been found that the high content of LC-PUFA oil alone can reduce the level of arachidonic acid in the tissues, and LC-PUFA in the form of emulsion is more easily absorbed by the body Molina et al (2020). designed an emulsion with lower EPA content and higher DHA/AA content to prevent EPA and DHA competing in the tissues.…”

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confidence: 99%

Omega‐3 polyunsaturated fatty acid encapsulation system: Physical and oxidative stability, and medical applications

Zhou

et al. 2022

Food Frontiers

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The benefits of omega-3 (ω-3) polyunsaturated fatty acids (PUFAs) to human health and the therapeutic properties of diseases have been widely identified. However, due to abundant double bonds, they are sensitive to environmental conditions which cause oxidative deterioration. This is one of the main factors limiting their application. The encapsulation of ω-3 PUFAs is an effective way to improve their oxidation stability. This review summarizes the recent advances in different forms of ω-3 encapsulation systems, such as emulsions, liposomes, microcapsules, and liquid crystalline. Particular emphasis is given to the effects of food-derived biopolymers wall materials (proteins, polysaccharides, and esters) on encapsulation efficiency and oxidation stability of ω-3 PUFAs encapsulation systems. In addition, the effects of natural antioxidants (polyphenols, carotenoids, flavonoids, plant essential oils, etc.) on the antioxidant enhancement of ω-3 PUFAs encapsulation system based on food-derived biopolymers are discussed.Different forms of ω-3 PUFAs encapsulation systems have been proven to be used as supplements in the medical field. The regulation and improvement of the ω-3 PUFAs encapsulation system on the diseases of animal and human, which are related to central nervous system, retina, lung, kidney and tissue cell, are systematically discussed.

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New generation lipid emulsions increase brain DHA and improve body composition, but not short-term neurodevelopment in parenterally-fed preterm piglets

Cited by 12 publications

References 24 publications

A Comparative Analysis of Lipid Digestion in Human Milk and Infant Formulas Based on Simulated In Vitro Infant Gastrointestinal Digestion

A Comparative Analysis of Lipid Digestion in Human Milk and Infant Formulas Based on Simulated In Vitro Infant Gastrointestinal Digestion

Smoflipid Is Better Than Lipofundin for Long-Term Neurodevelopmental Outcomes in Preterm Infants

Omega‐3 polyunsaturated fatty acid encapsulation system: Physical and oxidative stability, and medical applications

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