New frontiers in neonatal red blood cell transfusion research

Stark, Christopher M.; Juul, Sandra E.

doi:10.1038/s41372-023-01757-7

Cited by 5 publications

(3 citation statements)

References 78 publications

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“…Although we did not find the primary source of the infection, the need for prolonged NICU admission due to respiratory failure and feeding problems as well as the need for frequent transfusion of blood products (due to extensive hospital stay and frequent blood sample collection), and potential contact with silent healthcare provider carriers are among the potential source of the infection. The literature reports that the risk of CMV acquisition increases with blood transfusions 8-11. Acquisition of infection is assumed to have not occurred during intrauterine life since serologies (IgG, IgM), CMV, Toxoplasma gondii , Rubella virus, and Herpes simplex virus were negative.…”

Section: Discussionmentioning

confidence: 99%

Acquired Cytomegalovirus Retinitis in Preterm Infant Hospitalized in the NICU

Tajalli,

Vafaee,

Safi

et al. 2024

Advances in Neonatal Care

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Background: Acquired human cytomegalovirus (CMV) is a noteworthy disease in infants. This case study will highlight the influence of early diagnosis of CMV retinitis (CMVR) on avoid visual impairment. Clinical Findings: We describe a preterm female infant with a birth weight of 2060 gr that was admitted for tracheostomy placement due to hypoxic-ischemic encephalopathy. There were no signs of CMV infection or sepsis in laboratory results upon admission such as serology (IgG, IgM antibodies), Toxoplasma gondii, Rubella virus, Herpes simplex virus, CMVR and urine polymerase chain reaction (PCR). Primary Diagnosis: Incidentally, upon screening for retinopathy of prematurity, diffuse occlusive vasculitis was detected in the retinal image on the 112th day of life. Intervention: Intravenous and intraocular ganciclovir were administered for 4 weeks. Outcomes: In the follow-up visit 6 weeks after discharge from the hospital, visual impairment was detected on both sides. Practice Recommendations: This is a report of a case of acquired CMVR, a silent finding, as an uncommon complication in preterm neonates during the hospital stay. This diagnosis should be taken into consideration in preterm infants, since early diagnosis and treatment are crucial to avoid visual impairment.

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Section: Discussionmentioning

confidence: 99%

Acquired Cytomegalovirus Retinitis in Preterm Infant Hospitalized in the NICU

Tajalli,

Vafaee,

Safi

et al. 2024

Advances in Neonatal Care

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“…Finally, in Ref. 16 by considering guidelines, the effect of blood transfusion and relevant risks including adverse neurodevelopmental outcomes, the difference in donor sex, and inflammation are investigated in neonates. Therefore, blood transfusion is needed in cancer while it has side effects and we should be careful during its usage.…”

Section: Literature Reviewmentioning

confidence: 99%

Nano fuzzy alarming system for blood transfusion requirement detection in cancer using deep learning

Rady Raz,

Anoushirvani,

Rahimian

et al. 2024

Sci Rep

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Periodic blood transfusion is a need in cancer patients in which the disease process as well as the chemotherapy can disrupt the natural production of blood cells. However, there are concerns about blood transfusion side effects, the cost, and the availability of donated blood. Therefore, predicting the timely requirement for blood transfusion considering patient variability is a need, and here for the first-time deal with this issue in blood cancer using in vivo data. First, a data set of 98 samples of blood cancer patients including 61 features of demographic, clinical, and laboratory data are collected. After performing multivariate analysis and the approval of an expert, effective parameters are derived. Then using a deep recurrent neural network, a system is presented to predict a need for packed red blood cell transfusion. Here, we use a Long Short-Term Memory (LSTM) neural network for modeling and the cross-validation technique with 5 layers for validation of the model along with comparing the result with networking and non-networking machine learning algorithms including bidirectional LSTM, AdaBoost, bagging decision tree based, bagging KNeighbors, and Multi-Layer Perceptron (MLP). Results show the LSTM outperforms the other methods. Then, using the swarm of fuzzy bioinspired nanomachines and the most effective parameters of Hgb, PaO2, and pH, we propose a feasibility study on nano fuzzy alarming system (NFABT) for blood transfusion requirements. Alarming decisions using the Internet of Things (IoT) gateway are delivered to the physician for performing medical actions. Also, NFABT is considered a real-time non-invasive AI-based hemoglobin monitoring and alarming method. Results show the merits of the proposed method.

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“…The pathogenesis of these adverse outcomes of ELGANs is incompletely known, but associations with red blood cell (RBC) transfusions have been observed [4][5][6][7][8][9][10][11][12][13][14]. Puia-Dumitrescu et al reported that neonates weighing < 1000 grams at birth admitted to the Duke University Medical Center received a median of eight RBC transfusions (25th and 75th percentiles; 5, 10) [15].…”

Section: Introductionmentioning

confidence: 99%

Banked term umbilical cord blood to meet the packed red blood cell transfusion needs of extremely-low-gestational-age neonates: A feasibility analysis

Christensen,

Bahr,

Christensen

et al. 2023

Preprint

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OBJECTIVES: To assess the feasibility of drawing, processing, safety-testing, and banking term umbilical cord blood to meet the packed red blood cell transfusion (RBC Tx) needs of extremely-low-gestational-age neonates (ELGANs). DESIGN: 1) Retrospectively analyze all ELGANs RBC Tx over the past three years, 2) Estimate local cord blood availability, 3) Assess interest in this project, and implementation barriers, through stakeholder surveys. RESULTS: In three years we cared for 266 ELGANs; 165 (62%) received ≥1 RBC Tx. Annual RBC Tx averaged 197 (95% CI, 152 - 243). If 10% of our 10,353 annual term births had cord blood drawn and processed, and half of those tested were acceptable for Tx, collections would exceed the 95th % upper estimate for need by >four-fold. Interest exceeded 97%. Identified barriers included FDA approval, training to collect cord blood, and cost. CONCLUSION: RBC Tx needs of ELGANS could be met by local cord blood collection.

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New frontiers in neonatal red blood cell transfusion research

Cited by 5 publications

References 78 publications

Acquired Cytomegalovirus Retinitis in Preterm Infant Hospitalized in the NICU

Acquired Cytomegalovirus Retinitis in Preterm Infant Hospitalized in the NICU

Nano fuzzy alarming system for blood transfusion requirement detection in cancer using deep learning

Banked term umbilical cord blood to meet the packed red blood cell transfusion needs of extremely-low-gestational-age neonates: A feasibility analysis

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