New frontiers in in vitro medical diagnostics by low field T2 magnetic resonance relaxometry

Luo, Zhi Xiang; Fox, Lucius; Cummings, Matthew J.; Lowery, Thomas J.; Daviso, Eugenio

doi:10.1016/j.trac.2016.02.025

Cited by 27 publications

(20 citation statements)

References 72 publications

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“…Knowledge gained from studies in these areas provided the basis for the development of magnetic resonance imaging, a technique that is now widely used in medicine 45 47 . In addition, recent advances in low-field NMR relaxometry have been translated into blood-based diagnostic tests 48,49 .…”

Section: Discussionmentioning

confidence: 99%

Short-time Fourier Transform of Free Induction Decays for the Analysis of Serum Using Proton Nuclear Magnetic Resonance

et al. 2019

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Serum is the liquid portion of blood routinely used as a clinical specimen. Serum consists of low-molecular-weight compounds 1 3 , macromolecules and their degradation products 4, 5 , inorganic ions 6, 7 , and water. Hydrogen nuclei in serum play important roles through intra-and intermolecular interactions with other nuclei. Most of the hydrogen atoms in serum are associated with water molecules or proteins. Water molecules form hydrogen bonds with nitrogen and hydrogen atoms in macromolecules and low-molecular-weight compounds, stabilizing their molecular conformations 8 11. Hydrogen bonding also takes place in the interactions between solutes. Thus, serum has its own dynamic features and assumes a supramolecular structure

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Section: Discussionmentioning

confidence: 99%

Short-time Fourier Transform of Free Induction Decays for the Analysis of Serum Using Proton Nuclear Magnetic Resonance

et al. 2019

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“…Das grundlegende Prinzip entspricht der Wirkung von Kontrastmitteln in der medizinischen MRT, die dazu dienen, die Relaxationszeit zu verkürzen. Es wurden auf NMR‐Relaxometrie basierende diagnostische Bluttests für Candidose, Malaria und Blutstillung berichtet . Mit chipbasierten Systemen werden z.…”

Section: Laplace‐nmrunclassified

NMR mit Tischgeräten und deren Anwendungen von der Materialwissenschaft bis zur organischen Chemie

Blümich

Singh

2017

Angewandte Chemie

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Die NMR‐Spektroskopie ist eine unverzichtbare Analysemethode. Bis vor kurzem erforderten die Geräte viel Platz, waren teuer und schwer zu bedienen. Dies hat sich mit der Einführung kompakter NMR‐Spektrometer geändert, die sich für die Analyse kleiner Moleküle auf der Laborbank eignen. Solche Spektrometer sind mit Permanentmagneten für 1H‐NMR‐Frequenzen zwischen 40 und 80 MHz ausgestattet. Erst seit wenigen Jahren gibt es kleine Permanentmagnete mit homogenen Magnetfeldern für hochaufgelöste Spektroskopie. Tischgeräte mit inhomogenen Feldern werden schon seit 40 Jahren zur Charakterisierung von Lebensmitteln und Materialien über Relaxations‐ und Diffusionsmessungen genutzt. Ähnliche NMR‐Geräte messen diese Parameter im Streufeld außerhalb des Magneten. Sie werden zur Untersuchung von Bohrlochwänden in Ölquellen sowie für zerstörungsfreie Analysenverwendet. Der gegenwärtige Stand von NMR‐Spektroskopie, ‐Bildgebung und ‐Relaxometrie wird hier anhand repräsentativer Beispiele beschrieben.

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“…The applications of miniature NMR instruments are therefore expected to also be found in the life sciences with a demand created by a large fraction of the population. This path is already being explored with body fluid analyzers based on NMR relaxometry for detection of functionalized paramagnetic compounds that bind to disease markers [219][220][221][222][223][224][225] [ [226][227][228], envisioning handheld NMR-based point-of-care diagnostic tools [17,[229][230][231]. Two further lines of applications come to mind, one being a device like a health tracker and the other a metabolomic analyzer.…”

Section: Miniaturization and Conclusionmentioning

confidence: 99%

Mobile and Compact NMR

Blümich

2016

Modern Magnetic Resonance

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NMR with mobile and compact devices is experiencing considerable growth in recent years in particular since instruments have become available, which are capable not only of measuring NMR relaxation but also images and highresolution spectra. Based on permanent magnet technology, compact tabletop NMR instruments measure samples of materials and solutions positioned inside the magnet, while compact mobile instruments measure material properties of intact objects and samples nondestructively in the inhomogeneous stray field outside the magnet. Following a brief introduction to NMR with homogeneous and inhomogeneous magnetic fields and to the concepts of permanent center-and stray-field NMR magnets, the evolution of the technology over the past 10 years is reviewed and illustrated with selected applications. Relaxation and diffusion measurements find use in the analysis of foods, biological tissues, polymer materials, porous media, and objects of cultural heritage. Compact imaging

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New frontiers in in vitro medical diagnostics by low field T2 magnetic resonance relaxometry

Cited by 27 publications

References 72 publications

Short-time Fourier Transform of Free Induction Decays for the Analysis of Serum Using Proton Nuclear Magnetic Resonance

Short-time Fourier Transform of Free Induction Decays for the Analysis of Serum Using Proton Nuclear Magnetic Resonance

NMR mit Tischgeräten und deren Anwendungen von der Materialwissenschaft bis zur organischen Chemie

Mobile and Compact NMR

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