New fluoroquinolones/nitric oxide donor hybrids: design, synthesis and antitubercular activity

Recent Strategies in Design of Antitumor and Antibacterial Fluoroquinolones

“…As well as these compounds display DNA cleavage stimulation activities against mycobacteria species but less than parent ciprofloxacin. The growth inhibitory activities of these hybrids may be due to gyrase poisoning activities or NO-releasing effect [154].…”

Synthesis and antimicrobial evaluation of new nitric oxide‐donating fluoroquinolone/oxime hybrids

“…The formed cleaved complex can sequentially cause disturbance in normal DNA replication, induction of DNA damage, and cell death mechanisms. [20]…”

“…[ 13 ] As such, many approaches to develop new anti‐TB agents via hybridization of TB drugs with NO‐releasing moieties were developed (Figure 1). [ 15–20 ]…”

“…[13] As such, many approaches to develop new anti-TB agents via hybridization of TB drugs with NO-releasing moieties were developed (Figure 1). [15][16][17][18][19][20] Given the aforementioned reports, we herein examine the im- was carried out to study the impact of the introduced substitutions at the piperazinyl N-4 nitrogen on the overall binding with DNA gyrase.…”