New fluorescent probes based on gallium(III) corrole complexes for the recognition of hydrogen sulfide: A journey from solution to intracellular site

Santos, Carla I. M.; Santiago, AnaM.; Araújo, Ana R.L.; Pinto, Sandra N.; Agostinho, Rafaela R.; Simão, SóniaD.; Azevedo, TomásP.; Antunes, Sara C.; Faustino, Maria A. F.; Araújo, InêsM.; Neves, Maria G. P. M. S.; MARTINHO, JOSE MANUEL GASPAR; Maçôas, Ermelinda

doi:10.1016/j.dyepig.2023.111304

Cited by 4 publications

(2 citation statements)

References 46 publications

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“…In 2023, Santos and Macoâs reported 221 (CGa-NO 2 ) that showed a fluorescent shift from 750 to 612 nm in DMSO that was selective for H 2 S over biological anions and thiols, but was unable to image exogenous H 2 S in HeLa cells. 286 In 2016, Mahapatra reported 222 that featured nitro reduction followed by intramolecular cyclization to form a fluorescent coumarin derivative (Figure 51). 287 Incubation with H 2 S led to an 800-fold fluorescence turn-on at 484 nm 10% DMSO in buffer that was selective for H 2 S over RNS, ROS, and thiols.…”

Section: Nitro Reductionmentioning

confidence: 99%

“…The probe was used to image exogenous H 2 S and endogenous H 2 S confirmed by PMA in both HeLa and Raw 264.7 cells. In 2023, Santos and Maçôas reported 221 (CGa-NO 2 ) that showed a fluorescent shift from 750 to 612 nm in DMSO that was selective for H 2 S over biological anions and thiols, but was unable to image exogenous H 2 S in HeLa cells …”

Section: H2s Fluorescent Probes: Reduction Of Oxidized Nitrogen Motifsmentioning

confidence: 99%

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Activity-Based Fluorescent Probes for Hydrogen Sulfide and Related Reactive Sulfur Species

Fosnacht,

Pluth

2024

Chem. Rev.

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Hydrogen sulfide (H 2 S) is not only a well-established toxic gas but also an important small molecule bioregulator in all kingdoms of life. In contemporary biology, H 2 S is often classified as a "gasotransmitter," meaning that it is an endogenously produced membrane permeable gas that carries out essential cellular processes. Fluorescent probes for H 2 S and related reactive sulfur species (RSS) detection provide an important cornerstone for investigating the multifaceted roles of these important small molecules in complex biological systems. A now common approach to develop such tools is to develop "activitybased probes" that couple a specific H 2 S-mediated chemical reaction to a fluorescent output. This Review covers the different types of such probes and also highlights the chemical mechanisms by which each probe type is activated by specific RSS. Common examples include reduction of oxidized nitrogen motifs, disulfide exchange, electrophilic reactions, metal precipitation, and metal coordination. In addition, we also outline complementary activity-based probes for imaging reductant-labile and sulfane sulfur species, including persulfides and polysulfides. For probes highlighted in this Review, we focus on small molecule systems with demonstrated compatibility in cellular systems or related applications. Building from breadth of reported activity-based strategies and application, we also highlight key unmet challenges and future opportunities for advancing activity-based probes for H 2 S and related RSS.

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Section: Nitro Reductionmentioning

confidence: 99%

Section: H2s Fluorescent Probes: Reduction Of Oxidized Nitrogen Motifsmentioning

confidence: 99%

Activity-Based Fluorescent Probes for Hydrogen Sulfide and Related Reactive Sulfur Species

Fosnacht,

Pluth

2024

Chem. Rev.

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A Novel DNBS-based Fluorescent Probe for the Detection of H2S in Cells and on Test Strips

Wang,

Gan,

Jiang

et al. 2024

J Fluoresc

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A Versatile pH-Dependent Fluorometric, Colorimetric, and Electrochemical Sensor for H2S Monitoring in Water

Kulkarni,

Ranjana,

Ullal

et al. 2024

J Fluoresc

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New fluorescent probes based on gallium(III) corrole complexes for the recognition of hydrogen sulfide: A journey from solution to intracellular site

Cited by 4 publications

References 46 publications

Activity-Based Fluorescent Probes for Hydrogen Sulfide and Related Reactive Sulfur Species

Activity-Based Fluorescent Probes for Hydrogen Sulfide and Related Reactive Sulfur Species

A Novel DNBS-based Fluorescent Probe for the Detection of H2S in Cells and on Test Strips

A Versatile pH-Dependent Fluorometric, Colorimetric, and Electrochemical Sensor for H2S Monitoring in Water

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