New flavonol glycosides from the leaves of Allium victorialis var. platyphyllum

Woo, KW; Oh, Jy; Moon, Eunjung; Sy, Kim; Lee, KR

doi:10.1055/s-0032-1321285

Cited by 2 publications

(2 citation statements)

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“…Further isolation was carried out via semi-preparative HPLC for fractions M2 and M3, resulting in the isolation of nine metabolites, including glycosidic metabolites and caffeoylshikimic acids (Figure 1). The isolated compounds were identified as kaempferol 3,7-di-O-β-D-glucopyranoside (1) [31], icariside B 2 (2) [32], (Z)-3-hexenyl β-D-glucopyranoside (3) [33], luteolin 5-O-β-D-glucopyranoside (4) [34], 4-O-β-D-glucopyranosyl caffeic acid (5) [35], clemastanin B (6) [36], 4-O-caffeoylshikimic acid (7) [37], (7S,8S)-threo-7,9,9 -trihydroxy-3,3 -dimethoxy-8-O-4 -neolignan-4-O-β-D-glucopyranoside (8) [38], 3-O-caffeoylshikimic acid (9) [39]. These identifications were based on the comparison of their NMR spectra with reported data and HR-ESI-MS analysis (Figures S1-S18).…”

Section: Isolation and Identification Of The Compoundsmentioning

confidence: 99%

Phytochemical Investigation of Equisetum arvense and Evaluation of Their Anti-Inflammatory Potential in TNFα/INFγ-Stimulated Keratinocytes

Jeong,

Yu,

et al. 2023

Pharmaceuticals

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Equisetum arvense L. (Equisetaceae), widely known as ‘horsetail’, is a perennial plant found extensively across Asia. Extracts of E. arvense have been used in traditional medicine, particularly for the treatment of inflammatory disorders. This study aimed to determine the phytochemical compounds in E. arvense ethanolic extract and their anti-inflammatory properties. Subsequently, we isolated and identified nine secondary metabolites, including kaempferol 3,7-di-O-β-D-glucopyranoside (1), icariside B2 (2), (Z)-3-hexenyl β-D-glucopyranoside (3), luteolin 5-O-β-D-glucopyranoside (4), 4-O-β-D-glucopyranosyl caffeic acid (5), clemastanin B (6), 4-O-caffeoylshikimic acid (7), (7S,8S)-threo-7,9,9′-trihydroxy-3,3′-dimethoxy-8-O-4′-neolignan-4-O-β-D-glucopyranoside (8), and 3-O-caffeoylshikimic acid (9). The chemical structures of the isolated compounds (1–9) were elucidated using HR-ESI-MS data, NMR spectra, and ECD data. Next, the anti-inflammatory effects of the isolates were evaluated in tumor necrosis factor (TNF)α/interferon (IFN)γ-induced HaCaT, a human keratinocyte cell line. Among the isolates, compound 3 showed the highest inhibitory effect on the expression of pro-inflammatory chemokines, followed by compounds 6 and 8. Correspondingly, the preceding isolates inhibited TNFα/IFNγ-induced activation of pro-inflammatory transcription factors, signal transducer and activator of transcription 1, and nuclear factor-κB. Collectively, E. arvense could be employed for the development of prophylactic or therapeutic agents for improving dermatitis.

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Section: Isolation and Identification Of The Compoundsmentioning

confidence: 99%

Phytochemical Investigation of Equisetum arvense and Evaluation of Their Anti-Inflammatory Potential in TNFα/INFγ-Stimulated Keratinocytes

Jeong,

Yu,

et al. 2023

Pharmaceuticals

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“…In this study, chromatographic separation of EtOAc and BuOH fractions from Sample 6 of the Drynaria fortunei J. Smith species was performed. The isolated compounds were identified as gallic acid (1) [25], 5-hydroxymethylfurfural (2) [26], protocatechuic acid (3) [27], coumaric acid 4-O-β-D-glucopyranoside (4) [28][29][30], caffeic acid 4-O-β-D-glucopyranoside (5) [31][32][33][34][35], 4-hydroxybenzoic acid (6) [26], lavandoside (7) [29,36], trans-p-sinapoyl-β-D-glucopyranoside (8) [33,36], 5,7-dihydroxychromone-7-O-neohesperidoside (9) [9,31], kaempferol 3-O-rhamnoside 7-O-glucoside (10) [31], kaempferol 3-O-glucopyranoside-7-O-arabinofuranoside (11) [31,37], neoeriocitrin (12) [7], naringin (13) [38], and hesperidin ( 14) [38] through NMR and MS analyses and comparison with previous research results. The chemical structure of the isolated compound is presented in Figure 1, and the corresponding NMR and MS data are provided in Table S1.…”

Section: Structural Identification Of Isolated Compounds 1-14mentioning

confidence: 99%

The Development and Validation of Simultaneous Multi-Component Quantitative Analysis via HPLC–PDA Detection of 12 Secondary Metabolites Isolated from Drynariae Rhizoma

Ahn,

Whang

2023

Separations

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Drynariae Rhizoma (DR) is a functional food and traditional medicine that has been widely used for bone and joint disorders for thousands of years. In this study, 14 compounds were isolated from DR, and their structures were identified using UPLC/QTOF–MS, UPLC–ESI/LTQ–Orbitrap–HRMS, and 2D NMR and compared with those obtained in previous studies. An HPLC–PDA multi-component simultaneous quantitative determination method was developed for 12 of the 14 DR-derived compounds, excluding compounds with a content <1.5 mg. The developed HPLC method was validated based on linearity (r2 ≥ 0.999), limit of detection (0.01–0.65 μg/mL), limit of quantification (0.04–1.97 μg/mL), intra-day precision and accuracy ranges (0.06–2.85% and 95.03–104.75%, respectively), and inter-day precision and accuracy ranges (0.24–2.83% and 95.75–105.75%, respectively). The developed analysis method improved the resolution of compounds 4 and 5. In addition, this is the first quantitative analysis of compounds 7, 8, and 11 and the first simultaneous quantitative analysis of 12 compounds, including compounds 4, 7, 8, 10, 11, and 14. This study developed a rapid, accurate, and economical HPLC method for performing the simultaneous quantitative analysis of 12 secondary metabolites isolated from DR.

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New flavonol glycosides from the leaves of Allium victorialis var. platyphyllum

Cited by 2 publications

References 0 publications

Phytochemical Investigation of Equisetum arvense and Evaluation of Their Anti-Inflammatory Potential in TNFα/INFγ-Stimulated Keratinocytes

Phytochemical Investigation of Equisetum arvense and Evaluation of Their Anti-Inflammatory Potential in TNFα/INFγ-Stimulated Keratinocytes

The Development and Validation of Simultaneous Multi-Component Quantitative Analysis via HPLC–PDA Detection of 12 Secondary Metabolites Isolated from Drynariae Rhizoma

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