New Flavonoids Derivatives from with Antioxidant, Antimicrobial and Cyotoxic Activities

Abstract

Detailed investigation on leaves and bark of Artocarpus elasticus has led to the isolation of eight flavonoids derivatives including four new compounds, artoelastil (1), artoelastidi (2), artoelastiq (3), and artoelastidi (4) together with four known compound identified as cycloartocarpesin (5), artonin E (6), cycloartobiloxanthone (7) and artobiloxanthone (8). The structural elucidations of the pure compound were carried out using spectroscopic methods such as UV, IR, NMR, MS and also by comparison with published data. The compounds were tested for their biological activities on antioxidant, cytotoxic, and antimicrobial activities using standard method. Some of the isolated compounds exhibited interesting biological activity which can be further developed as potential antimicrobial, antioxidants and cytotoxic agents.

Artonin E and Structural Analogs from Artocarpus Species Abrogates Estrogen Receptor Signaling in Breast Cancer

“…It is exceptionally rich in phenolic secondary metabolites such as flavonoids, chalcones, xanthones and arylbenzofurans [10,11]. Some of these constituents have been reported to possess anti-inflammatory, anti-proliferative [12,13], antimicrobial [12] anti-tubercular [10] and antioxidant properties [14]. However, small molecules from this Artocarpus have not been investigated for their binding affinities to the human estrogen receptor and their drug-likeness has not been reported.…”