New ferro-carbon adsorbents for magnetically guided transport of anti-cancer drugs

Kuznetsov, Anatoly A.; Filippov, Victor I.; Кузнецов, О. А.; Gerlivanov, V.G.; Dobrinsky, Edward K.; Malashin, S. I.

doi:10.1016/s0304-8853(98)00568-x

Cited by 96 publications

(64 citation statements)

References 2 publications

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“…Finally, it should be mentioned that the cytotoxicity of this material is expected to be similar to the commercial iron oxide products, because its composition is chemically equivalent to the commercial products, which are considered as non toxic [45]. Moreover, the presence of small amounts of carbon was previously considered of low toxicity [46].…”

Section: Blood Clearance and Mri Studiesmentioning

confidence: 98%

Fe-based nanoparticulate metallic alloys as contrast agents for magnetic resonance imaging

et al. 2005

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Section: Blood Clearance and Mri Studiesmentioning

confidence: 98%

Fe-based nanoparticulate metallic alloys as contrast agents for magnetic resonance imaging

et al. 2005

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“…Magnetic targeting of drugs decreases the quantities of an active agent by several orders of magnitude and increases its concentration at the tumor site by dozens of times. It involves magnetic targeted carriers, most commonly, suspensions of ultradispersed magnetic iron-and carbon-containing particles (sorbents) the surface of which is modified and loaded with an active agent (various compounds) as proposed previously (Kuznetsov et al , 1997(Kuznetsov et al , , 1999. A drug is associated with magnetic particles due to the absorption on carbon.…”

Section: Introductionmentioning

confidence: 97%

Development of the Method of Magnetic Neutron Capture Therapy of Cancer

et al. 2005

Biol Bull Russ Acad Sci

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The method of magnetic neutron capture therapy (MNTC) of cancer can be described as a combination of two methods: the targeted delivery of drugs using magnetic carriers and the proper neutron capture therapy which consists in tumor irradiation with thermal neutrons following the delivery of 10 B compounds to the tumor site. Two-component ultradispersed particles containing Fe and C were tested as magnetic adsorbents of boron phenylalanine and borax. The quantities of absorbed borax proved sufficient for high concentration of boron atoms at the tumor site. The kinetics of boron release to saline substantiates the application of Fe-B (10%) ultradispersed particles for efficient MNTC. Both particle types have high magnetization and magnetic homogeneity, can form stable magnetic suspensions, and have low toxicity.

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“…15 Briefly, a streptomycin solution (0.58 g) was added dropwise while stirring into an aqueous dispersion of MNP. The mixture of CS-MNP in the streptomycin solution was magnetically stirred at room temperature for 18 hours to facilitate streptomycin uptake.…”

Section: Preparation Of Strep-cs-mnpmentioning

confidence: 99%

Synthesis, characterization, controlled release, and antibacterial studies of a novel streptomycin chitosan magnetic nanoantibiotic

Hussein‐Al‐Ali¹,

Zowalaty²,

Hussein³

et al. 2014

IJN

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This study describes the preparation, characterization, and controlled release of a streptomycin-chitosan-magnetic nanoparticle-based antibiotic in an effort to improve the treatment of bacterial infections. Specifically, chitosan-magnetic nanoparticles were synthesized by an incorporation method and were characterized by Fourier transform infrared spectroscopy, X-ray diffraction, thermogravimetric analysis, and vibrating sample magnetometry. Streptomycin was incorporated into the nanoparticles to form a streptomycin-coated chitosan-magnetic nanoparticle (Strep-CS-MNP) nanocomposite. The release profiles showed an initially fast release, which became slower as time progressed. The percentage of drug released after 350 minutes was around 100%, and the best fit mathematical model for drug release was the pseudo-second order model. The Strep-CS-MNP nanocomposite showed enhanced antibacterial activity against methicillin-resistant Staphylococcus aureus . This study forms a significant basis for further investigation of the Strep-CS-MNP nanocomposite in the treatment of various bacterial infections.

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New ferro-carbon adsorbents for magnetically guided transport of anti-cancer drugs

Cited by 96 publications

References 2 publications

Fe-based nanoparticulate metallic alloys as contrast agents for magnetic resonance imaging

Fe-based nanoparticulate metallic alloys as contrast agents for magnetic resonance imaging

Development of the Method of Magnetic Neutron Capture Therapy of Cancer

Synthesis, characterization, controlled release, and antibacterial studies of a novel streptomycin chitosan magnetic nanoantibiotic

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