New facets of nanozyme activity of ceria: lipo- and phospholipoperoxidase-like behaviour of CeO<sub>2</sub> nanoparticles

Sozarukova, Madina M.; Проскурнина, Е. В.; Попов, А. И.; Калинкин, А. Л.; Ivanov, V. K.

doi:10.1039/d1ra06730c

Cited by 22 publications

(8 citation statements)

References 96 publications

(134 reference statements)

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“…Lipids and phospholipids are key components in cells. They modulate the permeability of membranes, act as their supporting framework, and participate in signal transmission in response to external and internal stimuli [ 80 ]. Therefore, the biochemical activity of EGO concerning lipids and phospholipids was investigated.…”

Section: Resultsmentioning

confidence: 99%

Green and Sustainable Ultrasound-Assisted Anodic Electrochemical Preparation of Graphene Oxide Dispersions and Their Antioxidant Properties

et al. 2023

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A fast method for preparing aqueous graphene oxide (GO) dispersions by electrochemical oxidation of a graphite anode without preliminary intercalation with oxidizing agents is proposed. Ultrasonic probing was used in the modulation mode of ultrasonic waves (work/rest) for more efficient graphite oxidation–exfoliation. It is shown that the 4/2 s mode of ultrasonic modulation is the most effective due to the probe material’s low corrosion while maintaining the optimum synthesis temperature not exceeding 30–35 °C and achieving the best characteristics of the resulting product. Three cases of anodic oxidation of graphite to obtain graphene oxide were considered: (1) a combined cathode–anode compartment, (2) a split cathode–anode salt-bridged compartment, and (3) separated anode compartment with a 3.5 kDa dialysis membrane. It was determined that the approach to synthesis with a divided cathode–anode compartment makes it possible to obtain GO sheets with fewer defects compared to chemical methods or methods with a combined cathode–anode compartment and makes it possible to control the oxidation degree of the material (C:O ratio) by varying the current density. The prepared samples showed good stability for more than six months. The spectral and morphological characteristics were studied. Using chemiluminometry in the luminol/Co(II)/H2O2 system, the antioxidant properties concerning three key reactive oxygen species (H2O2, superoxide anion radical, and hydroxyl radical) were demonstrated. It was also shown that the prepared GO dispersions do not induce lipid and phospholipid peroxidation.

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Section: Resultsmentioning

confidence: 99%

Green and Sustainable Ultrasound-Assisted Anodic Electrochemical Preparation of Graphene Oxide Dispersions and Their Antioxidant Properties

et al. 2023

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“…91 Further types of CeO 2 NMs activities, namely, lipoperoxidase and phospholipoperoxidase, have also been discovered recently. 92 Lipid hydroperoxide and phosphatidylcholine hydroperoxide decomposed catalytically at CeO 2 NMs in the presence of organic peroxide substrates.…”

Section: Haloperoxidasementioning

confidence: 99%

“…Moreover, CeO 2 NPs can mimic the DNase I activity for cleaving single-stranded DNA oligonucleotides, which cleave DNA into smaller pieces than DNase I. Porous CeO 2 nanorods (PN-CeO 2 ) can also mimic the DNA photolyase-like activity that breaks cyclobutene pyrimidine dimers (CPDs) into monomers to repair UV-induced DNA damage . Further types of CeO 2 NMs activities, namely, lipoperoxidase and phospholipoperoxidase, have also been discovered recently . Lipid hydroperoxide and phosphatidylcholine hydroperoxide decomposed catalytically at CeO 2 NMs in the presence of organic peroxide substrates.…”

Section: Catalytic Mechanism Of Ceo2 Nmsmentioning

confidence: 99%

Nanoceria-Based Artificial Nanozymes: Review of Materials and Applications

Xiao

Zhao

et al. 2022

ACS Appl. Nano Mater.

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Nanozymes are nanomaterial-based enzyme mimics that have dominated recent research because of their remarkable catalytic activity, stability, and low cost. Among them, CeO2 nanomaterials (CeO2 NMs) possess distinct physicochemical properties and inherent catalytic properties mimicking oxidase (OXD), peroxidase (POD), catalase (CAT), superoxide dismutase (SOD), phosphatase, nuclease, and photolyases. The surface valence state, Ce4+/Ce3+ conversion, and oxygen vacancies (OVs) on the surface of CeO2 NMs are closely associated with enzyme-like activities. Surface modification (ions, small molecules, and macromolecular capping) can strongly promote or inhibit their catalytic activities. CeO2 NMs have emerged as attractive materials for biochemical applications including biocatalytic conversion, pollutant destruction, antimicrobial therapies, biosensors, and disease therapies. We summarize here the development history, catalytic mechanisms, and surface modification methods of CeO2 mimetic enzymes and the exploration of their applications as alternatives to natural enzymes in biochemical fields. Further, we outline potential challenges and prospects and hope to provide better guidance for the design and application of these promising artificial enzymes.

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“…42,43 Note that, in the authors' most recent report, the notable prooxidant activity of CeO 2 nanoparticles towards lipids and phospholipids has been shown. 44…”

Section: Introductionmentioning

confidence: 99%

“…42,43 Note that, in the authors' most recent report, the notable prooxidant activity of CeO 2 nanoparticles towards lipids and phospholipids has been shown. 44 Cerium phosphates are of considerable interest as inorganic UV-filters, as they are expected to be free from limitations inherent in cerium dioxide. In cerium(III) and cerium(IV) compounds, broad and intense bands in the UV region arise from 4f-5d transitions and charge transfer from oxygen to cerium ions, respectively.…”

Section: Introductionmentioning

confidence: 99%

Amorphous and crystalline cerium(iv) phosphates: biocompatible ROS-scavenging sunscreens

et al. 2022

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New facets of nanozyme activity of ceria: lipo- and phospholipoperoxidase-like behaviour of CeO₂ nanoparticles

Abstract: CeO2 nanoparticles were shown to possess two novel types of enzyme-like activity, namely lipoperoxidase and phospholipoperoxidase activity.

Cited by 22 publications

References 96 publications

Green and Sustainable Ultrasound-Assisted Anodic Electrochemical Preparation of Graphene Oxide Dispersions and Their Antioxidant Properties

Green and Sustainable Ultrasound-Assisted Anodic Electrochemical Preparation of Graphene Oxide Dispersions and Their Antioxidant Properties

Nanoceria-Based Artificial Nanozymes: Review of Materials and Applications

Amorphous and crystalline cerium(iv) phosphates: biocompatible ROS-scavenging sunscreens

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New facets of nanozyme activity of ceria: lipo- and phospholipoperoxidase-like behaviour of CeO2 nanoparticles

Abstract: CeO2 nanoparticles were shown to possess two novel types of enzyme-like activity, namely lipoperoxidase and phospholipoperoxidase activity.

Cited by 22 publications

References 96 publications

Green and Sustainable Ultrasound-Assisted Anodic Electrochemical Preparation of Graphene Oxide Dispersions and Their Antioxidant Properties

Green and Sustainable Ultrasound-Assisted Anodic Electrochemical Preparation of Graphene Oxide Dispersions and Their Antioxidant Properties

Nanoceria-Based Artificial Nanozymes: Review of Materials and Applications

Amorphous and crystalline cerium(iv) phosphates: biocompatible ROS-scavenging sunscreens

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Product

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New facets of nanozyme activity of ceria: lipo- and phospholipoperoxidase-like behaviour of CeO₂ nanoparticles