New extensometer to measure in vivo uniaxial mechanical properties of human skin

Lim, Kok Hwa; Chew, Chee-Meng; Chen, P.C.Y.; Jeyapalina, Sujee; Ho, H.N.; Rappel, James K.; Lim, Brian Y.

doi:10.1016/j.jbiomech.2008.01.004

Cited by 67 publications

(48 citation statements)

References 13 publications

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“…What is to be specified is the ability of the interface to resist three different types of stresses: compressive stresses at a right angle to the interface; tensile stresses, also at a right angle to the interface; and shear stresses in parallel with the interface ( Linear static models have been employed extensively in previous FEA studies. (Kohal et al 2002;Menicucci, Mossolov et al 2002;Romanos 2004;Van Staden et al 2006;Lim, Chew et al 2008;Eser, Akca et al 2009;Hsu et al 2009;Li, Kong et al 2009;Faegh and Muftu 2010;Freitas Junior et al 2010;Hasan et al 2011) These analyses usually assumed that all modeled volumes were bonded as one unit, which indicates that the trabecular and cortical bone are perfectly bonded to the implant interface. (Winter et al 2004;Maeda et al 2007;Fazel et al 2009;Chang, Chen et al 2010;Okumura, Stegaroiu et al 2010).…”

Section: Bone-implant Interfacementioning

confidence: 99%

“…(Kohal, Papavasiliou et al 2002;Menicucci, Mossolov et al 2002;Romanos 2004;Van Staden, Guan et al 2006;Lim, Chew et al 2008;Eser, Akca et al 2009;Hsu, Fuh et al 2009;Faegh and Muftu 2010;Freitas Junior, Rocha et al 2010;Hasan, Rahimi et al 2011) This assumption is supported by experimental investigations in which removal of rough implants frequently resulted in fractures i n b o n e d i s t a n t f r o m the implant surface, (Gotfredsen et al 2000) suggesting the existence of an implant-bone "bond". On the other hand, frictional contact elements are used to simulate a nonintegrated bone to implant interface (i.e.…”

Section: Bone-implant Interfacementioning

confidence: 99%

“…The analysis criteria widely used in implant prosthodontics are: (1) von Mises stress (σ vM ) (Yokoyama, Wakabayashi et al 2005;Assuncao, Tabata et al 2008;Huang, Hsu et al 2008;Lim, Chew et al 2008;Rubo and Souza 2008;Schrotenboer et al 2008;Assuncao et al 2009;Assuncao et al 2009;Chaichanasiri, Nanakorn et al 2009;Ding et al 2009;Fazel, Aalai et al 2009;Gomes et al 2009;Kong et al 2009;Li, Kong et al 2009;Qian et al 2009;Abreu et al 2010;Ao et al 2010;Caglar et al 2010;Eraslan and Inan 2010;Eser et al 2010;Faegh and Muftu 2010;Gomes et al 2010;Miyamoto et al 2010;Okumura, Stegaroiu et al 2010;Sagat, Yalcin et al 2010;Takahashi et al 2010;Teixeira et al 2010;Winter et al 2010;Bevilacqua et al 2011;Burak Ozcelik, Ersoy et al 2011;de Almeida, Rocha et al 2011;Okumura et al 2011), (2) maximum and minimum principal elastic strain (Є max and Є min ) (Saab et al 2007;Qian, Todo et al 2009;Chou, Muftu et al 2010;Danza, Quaranta et al 2010;Eser, Tonuk et al 2010;Limbert et al 2010;Okumura, Stegaroiu et al 2010;de Almeida, Rocha et al 2011) and (3) maximum and minimum principal ...…”

Section: Analysis Criteria Involved In Steps Of the Feamentioning

confidence: 99%

“…Although there are several implant dentistry studies using the FEA method, (Rayfield 2004;Yokoyama et al 2005;Galantucci et al 2006;Huang et al 2007;Assuncao et al 2008;Lim et al 2008;de Almeida et al 2011) each step of the method deserves discussion in order to facilitate its understanding when applied to implant/restoration/bone system. Thus, the aim of this chapter is to conduct a critical review of simulated biomechanical scenarios describing essential basic aspects and approaches currently used in implantology.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Critical Aspects for Mechanical Simulation in Dental Implantology

Almeida¹,

Júnior²,

Rocha³

et al. 2012

Finite Element Analysis - From Biomedical Applications to Industrial Developments

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Section: Bone-implant Interfacementioning

confidence: 99%

Section: Bone-implant Interfacementioning

confidence: 99%

Section: Analysis Criteria Involved In Steps Of the Feamentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Critical Aspects for Mechanical Simulation in Dental Implantology

Almeida¹,

Júnior²,

Rocha³

et al. 2012

Finite Element Analysis - From Biomedical Applications to Industrial Developments

View full text Add to dashboard Cite

“…Current research devices and clinical products for in vivo skin assessment typically employ a single mode or method of deformation, such as suction [1][2][3][4][5], torsion [6,7], indentometry [8][9][10][11], ballistometry [12], shear deformation [13][14][15], or extensometry [16][17][18]. Mechanical properties reported using these techniques vary widely.…”

Section: Introductionmentioning

confidence: 99%

Multidirectional In Vivo Characterization of Skin Using Wiener Nonlinear Stochastic System Identification Techniques

Parker

Jones

Hunter

et al. 2016

Journal of Biomechanical Engineering

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A triaxial force-sensitive microrobot was developed to dynamically perturb skin in multiple deformation modes, in vivo. Wiener static nonlinear identification was used to extract the linear dynamics and static nonlinearity of the force-displacement behavior of skin. Stochastic input forces were applied to the volar forearm and thenar eminence of the hand, producing probe tip perturbations in indentation and tangential extension. Wiener static nonlinear approaches reproduced the resulting displacements with variances accounted for (VAF) ranging 94-97%, indicating a good fit to the data. These approaches provided VAF improvements of 0.1-3.4% over linear models. Thenar eminence stiffness measures were approximately twice those measured on the forearm. Damping was shown to be significantly higher on the palm, whereas the perturbed mass typically was lower. Coefficients of variation (CVs) for nonlinear parameters were assessed within and across individuals. Individual CVs ranged from 2% to 11% for indentation and from 2% to 19% for extension. Stochastic perturbations with incrementally increasing mean amplitudes were applied to the same test areas. Differences between full-scale and incremental reduced-scale perturbations were investigated. Different incremental preloading schemes were investigated. However, no significant difference in parameters was found between different incremental preloading schemes. Incremental schemes provided depth-dependent estimates of stiffness and damping, ranging from 300 N/m and 2 Ns/m, respectively, at the surface to 5 kN/m and 50 Ns/m at greater depths. The device and techniques used in this research have potential applications in areas, such as evaluating skincare products, assessing skin hydration, or analyzing wound healing.

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Microneedle Arrays for Drug Delivery and Diagnostics: Toward an Optimized Design, Reliable Insertion, and Penetration

Ebrahiminejad

Prewett

Davies

et al. 2022

Adv Materials Inter

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DDS can also be in the form of rapid parenteral intravenous, intramuscular, or subcutaneous delivery, which is suitable for emergency situations and mostly accompanied with pain, and hence not preferred by patients. [2,3] Inhalation drug delivery is a painless DDS method received through the lungs that is mainly used for respiratory diseases with the risk of overdosing upon self-administrations. [4] Another method of drug delivery is transdermal drug delivery through skin layers via application of creams, hypodermic needles, ultrasound, electroporation, iontophoresis, or use of microneedles (MNs). [4][5][6] In therapeutic monitoring, early stage diagnostics, efficiency of biological samples, timely analysis, non-invasiveness, and potential for self-administration are all highly desirable. [7] Point-of-care (POC) medical tests using MNs have the potential to provide rapid, minimally invasive, and real time diagnostics, [7] sampling either capillary blood or interstitial fluid (ISF) in competition with venous blood, breath, stool, and sputum. ISF has been shown to contain 83% of serum proteins, only 50% of which are found in serum, indicting the significance of ISF biomarkers for monitoring and diagnostics. [8,9] Therefore, ongoing pathophysiological events such as chronic conditions can be rapidly and painlessly detected using POC MN diagnostic systems enabling collection of ISF samples with unique biomarkers using MN systems. [10] Single MNs can be used as a painless alternative to steel hypodermic needles but they are more likely to be used as arrays of multiple MNs incorporated into diagnostic or therapeutic patches. [11] Their painless, non-invasive, and selfadministrative capabilities have received increasing attention in recent years. [12] Conventional hypodermic needles can induce pain, are semi-invasive, create hazardous wastes, and require trained medical staff for administration. Instead, minimally invasive MNs can be administrated without discomfort to the patient by bypassing the stratum corneum (SC) barrier of skin, [12][13][14] while avoiding contact with nerve system and blood vessels. It can be self-administrated and create less waste in comparison to the traditional hypodermic needles. [15][16][17] MNs are potentially capable of delivering ionic, hydrophilic, and large molecular weight drugs more effectively than passive diffusion using needle-free patches or topical creams. [18,19] Thus, MNs are an attractive candidate for delivery of drugs including insulins, growth hormones, proteins, siRNA, immunobiological,

show abstract

New extensometer to measure in vivo uniaxial mechanical properties of human skin

Cited by 67 publications

References 13 publications

Critical Aspects for Mechanical Simulation in Dental Implantology

Critical Aspects for Mechanical Simulation in Dental Implantology

Multidirectional In Vivo Characterization of Skin Using Wiener Nonlinear Stochastic System Identification Techniques

Microneedle Arrays for Drug Delivery and Diagnostics: Toward an Optimized Design, Reliable Insertion, and Penetration

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