New evidences that discard the possible vertical transmission of SARS-CoV-2 during pregnancy

Cai, Jingye; Zhang, Yingzi; Tang, Mi

doi:10.1016/j.medcli.2020.09.021

Cited by 6 publications

(5 citation statements)

References 5 publications

(4 reference statements)

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“…COVID-19 caused a pandemic affecting the whole world, and it is inevitable that pregnant women were infected. Therefore, the presence of vertical transmission to the fetus was evaluated in many studies (14)(15)(16). It is known that COVID-19 affects many systems, and neurologic effects were also reported.…”

Section: Discussionmentioning

confidence: 99%

Is Gestational COVID-19 a Risk Factor for Congenital Hearing Loss?

et al. 2022

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The aim of this study was to investigate whether COVID-19 during pregnancy is a risk factor for congenital hearing loss. Study Design: Retrospective cohort. Setting: Tertiary referral center. Patients: Hearing screening test results of 60,223 newborns between March 2020 and May 2021 were screened using the national database. Newborn babies of 570 pregnant women with positive COVID-19 PCR test during pregnancy who met the study criteria were included in the gestational COVID-19 group, and 570 healthy newborns born in the same period were included in the control group. Intervention: Diagnostic. Main Outcome Measure: Results of up to three automatic auditory brainstem response tests in the first 30 days of life were used for newborn hearing screening. Results: When the gestational COVID-19 and control groups were compared in terms of demographic data, there was no statistically significant difference for any of the variables (maternal age, gestational age, birth weight, neonate gender, mode of delivery, p > 0.05 for all variables). Of the mothers in the gestational COVID-19 group, 62 (10.9%) had COVID-19 in the first trimester, 181 (31.8%) in the second trimester, and 327 (57.3%) in the third trimester. When the first and second test results of newborn hearing screening were compared between the groups, the number of babies with hearing loss was higher in the gestational COVID-19 group than in the control group (p = 0.025; odds ratio, 1.357; 95% confidence interval, 1.039-1.774; p = 0.006; odds ratio, 4.924; 95% confidence interval, 1. 410-17.193, respectively). For the third test results, hearing loss was detected in only one baby in both groups (p = 0.284). When the first, second, and third test results for newborn hearing screening were compared according to the trimesters when COVID-19 positivity was identified, the difference between trimesters was not found to be statistically significant (p > 0.05). Conclusion:To the best of our knowledge, this is the largest study in the literature of the impact of COVID-19 on newborn hearing. The findings in the study suggest that gestational COVID-19 is not a risk factor for permanent congenital hearing loss. However, because the risk of detecting hearing loss is high in the first 15 days, we emphasize the importance of the third screening test.

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Section: Discussionmentioning

confidence: 99%

Is Gestational COVID-19 a Risk Factor for Congenital Hearing Loss?

et al. 2022

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“…Therefore, it is reasonable to speculate that the proinflammatory state of SARS-CoV-2 infection during pregnancy may precipitate negative consequences in children [ 13 , 14 ]. In addition to potential risk of vertical transmission, SARS-CoV-2 may indirectly lead to adverse perinatal and longer-term neurodevelopmental outcomes [ 15 , 16 ]. The inner ear is a complex structure which starts to develop early during pregnancy (Carnegie stages 14–16) and progresses during early gestation.…”

Section: Introductionmentioning

confidence: 99%

Maternal COVID-19 and neonatal hearing loss: a multicentric survey

Mostafa

Mostafa²,

Fiky

et al. 2021

Eur Arch Otorhinolaryngol

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Purpose Gestational SARS-Cov-2 infection can impact maternal and neonatal health. The virus has also been reported of causing sensorineural hearing loss. The objective of this study was to determine the possible effect of maternal SARS-COV-2 infection on neonatal hearing as identified during universal hearing screening. Methods Retrospective cohort study in two tertiary referral centers including all neonates born from November 2020 through April 1st, 2021 and undergoing the universal hearing screening program. Maternal Covid-19 infection was recorded (timing and severity) and the results of hearing screening of their neonates compared to the incidence of neonatal hearing loss results of the national universal screening program during the same period. Results A total of 984 neonates were included (508 males and 476 females). Sixty-three neonates were excluded due to comorbidities which could cause hearing loss. The incidence of failed responses in the community at large was 2.3%. Twenty-seven failed both steps of screening (2.9%; p < 0.2). There were 34 Covid-19 positive mothers (17 in the first trimester, 8 in the second and 9 in the third). Twenty-nine neonates failed the first screening ( p < 0.00001) but on further testing only one neonate failed (2.9%). Conclusion In this study, neonates born to Covid-19 positive mothers do not seem to have an increased risk of hearing loss. However longer follow-up of these neonates is mandatory to detect any possible delayed effects of the virus.

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“…e rate of vertical transmission was 5.3% (1.3-16), and the rate of positive SARS-CoV-2 tests for neonates born to mothers with COVID-19 was 8% [4][5][6][7][8][9][10][11][12][13][14][15][16]. A low risk of vertical transmission is present, and SARS-CoV-2 can be detected in all conception products, particularly placenta and breast milk.…”

Section: Introductionmentioning

confidence: 99%

“…Later, the fully developed inner ear may be vulnerable to infections or ototoxic insults [11]. SARS-CoV-2 may indirectly lead to adverse perinatal and long-term neurodevelopmental outcomes [10,12]. e virus has also been reported to cause sensorineural hearing loss [13,14].…”

Section: Introductionmentioning

confidence: 99%

Comparison of Perinatal, Newborn, and Audiometry Results of COVID-19 Pregnant Women

Yılmaz

Aksin

Balsak

et al. 2022

International Journal of Clinical Practice

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Objective. There are studies on the perinatal outcomes of COVID-19, but the audiometric effects of the maternal immune system against COVID-19 in the newborn are not clear. In this study, we aimed to investigate the relationship between the perinatal outcomes of COVID-19 positive pregnant women and the audiological outcomes of newborns. Materials and Methods. This retrospective, single-center cohort study was conducted with 65 polymerase chain reaction (PCR) positive pregnant women and newborns and 66 normal pregnant women and newborns who were admitted between January 2020–December 2021. Pregnancy data, perinatal outcomes, and newborn hearing test results of pregnant women and newborns were recorded and compared. Results. A total of 131 patients were enrolled in the study. The number of normal pregnant women was 66 (50.4%) and the number of pregnant women who had COVID-19 disease was 65 (49.6%). In general, gestational week, age, parity, biochemical parameters, duration of hospital stay, week of delivery, fetal weight, and apgar scores were compared between pregnant women with COVID-19 and normal. White blood cell (WBC), neutrophil, aspartate aminotransferase (AST), and C-reactive protein (CRP) parameters were found to be significantly higher, and lymphocyte and neutrophil/lymphocyte (N/L) ratios were significantly lower ( p < 0.05 ). There was no statistically significant difference between the two groups (χ2=0.001; p = 1,000 ). The normal delivery status, the normal delivery rate in patients with COVID-19 was found to be statistically significantly higher than the cesarean section delivery status ( p = 0.012 ). In the statistical comparison between the COVID-19 and normal pregnant groups in the cesarean section group, the gestational week, delivery week, and apgar1 scores of the pregnant women with COVID-19 were found to be significantly higher. There was no statistically significant difference between the distributions of the rate of infants with hearing impairment in the comparison with hearing tests in pregnant women with COVID-19 (n=1) and normal pregnant women (n=1) (χ2=0.001; p = 1,000 ). Conclusion. Although the negative effects of COVID-19 on pregnancy outcomes are rare, it was determined that there was no increased audiological risk factor, and the most important predictor of COVID-19 was lymphopenia.

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New evidences that discard the possible vertical transmission of SARS-CoV-2 during pregnancy

Cited by 6 publications

References 5 publications

Is Gestational COVID-19 a Risk Factor for Congenital Hearing Loss?

Is Gestational COVID-19 a Risk Factor for Congenital Hearing Loss?

Maternal COVID-19 and neonatal hearing loss: a multicentric survey

Comparison of Perinatal, Newborn, and Audiometry Results of COVID-19 Pregnant Women

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