New evaluation of the in vitro response of silicocarnotite monophasic material

Serena, S.; Caballero, A.; Aza, Piedad N. De; Saínz, M.A.

doi:10.1016/j.ceramint.2015.03.319

Cited by 31 publications

(53 citation statements)

References 39 publications

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“…3, curve b) we can observe some absorption bands at 520, 543, 606, and 840 cm -1 , which are indicative for crystalline HA structures. In addition, the peaks at 868, 939 and 1060 cm -1 can be assigned to the silicocarnotite (S) formed in the studied composite [41,42]. The absorption maxima, visible at ∼720 cm -1 could be related to the presence of HM and amide V. From the FTIR presented results, we can conclude that our data are in accordance with our previous XRD results [32].…”

Section: Resultssupporting

confidence: 91%

In vitro bioactivity of glass-ceramic/fibroin composites

Radev

Michailova

Stateva

et al. 2017

PAC

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Bioactive composite materials were prepared by mixing 20 wt.% of silk fibroin (SF) and 80 wt.% of glassceramics from CaO-SiO 2-P 2 O 5-MgO system. In vitro bioactivity of the prepared composites was evaluated in 1.5 simulated body fluid (1.5 SBF) in static conditions. The obtained samples before and after in vitro tests were characterized by X-ray diffraction (XRD) analysis, Fourier transform infrared spectroscopy (FTIR), and X-ray photoelectron spectroscopy (XPS). The changes in 1.5 SBF solutions after soaking the samples were evaluated by inductively coupled plasma atomic emission spectroscopy (ICP-AES). MG63 osteosarcoma cells were used for the biological experiments. The obtained experimental data proved that the synthesized composites exhibit excellent in vitro bioactivity.

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Section: Resultssupporting

confidence: 91%

In vitro bioactivity of glass-ceramic/fibroin composites

Radev

Michailova

Stateva

et al. 2017

PAC

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“…Soaking in SBF led to distinctive surface remodeling in all of the cases. After the 24-h setting (Figure 5A), the surface of the paste exhibited the typical granular porous microstructure with the characteristic apatite morphology to those formed in the bioactive materials [12,17,28]. After prolonged soaking for up to 21 days (Figure 5B,C), clusters of agglomerated bone-like apatite particles increased and the cement’s surface structure became more compact.…”

Section: Resultsmentioning

confidence: 99%

A New Biphasic Dicalcium Silicate Bone Cement Implant

Zuleta

Murciano

Gehrke³

et al. 2017

Materials

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This study aimed to investigate the processing parameters and biocompatibility of a novel biphasic dicalcium silicate (C2S) cement. Biphasic α´L + β-C2Sss was synthesized by solid-state processing, and was used as a raw material to prepare the cement. In vitro bioactivity and biocompatibility studies were assessed by soaking the cement samples in simulated body fluid (SBF) and human adipose stem cell cultures. Two critical-sized defects of 6 mm Ø were created in 15 NZ tibias. A porous cement made of the high temperature forms of C2S, with a low phosphorous substitution level, was produced. An apatite-like layer covered the cement’s surface after soaking in SBF. The cell attachment test showed that α´L + β-C2Sss supported cells sticking and spreading after 24 h of culture. The cement paste (55.86 ± 0.23) obtained higher bone-to-implant contact (BIC) percentage values (better quality, closer contact) in the histomorphometric analysis, and defect closure was significant compared to the control group (plastic). The residual material volume of the porous cement was 35.42 ± 2.08% of the initial value. The highest BIC and bone formation percentages were obtained on day 60. These results suggest that the cement paste is advantageous for initial bone regeneration.

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“…Details of the technique and characterisation of the starting materials can be found in previous publications [21,22,23,24]. …”

Section: Methodsmentioning

confidence: 99%

Assessment of Effects of Si-Ca-P Biphasic Ceramic on the Osteogenic Differentiation of a Population of Multipotent Adult Human Stem Cells

et al. 2016

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A new type of bioceramic with osteogenic properties, suitable for hard tissue regeneration, was synthesised. The ceramic was designed and obtained in the Nurse’s A-phase-silicocarnotite subsystem. The selected composition was that corresponding to the eutectoid 28.39 wt % Nurse’s A-phase-71.61 wt % silicocarnotite invariant point. We report the effect of Nurse’s A-phase-silicocarnotite ceramic on the capacity of multipotent adult human mesenchymal stem cells (ahMSCs) cultured under experimental conditions, known to adhere, proliferate and differentiate into osteoblast lineage cells. The results at long-term culture (28 days) on the material confirmed that the undifferentiated ahMSCs cultured and in contact with the material surface adhered, spread, proliferated, and produced a mineralised extracellular matrix on the studied ceramic, and finally acquired an osteoblastic phenotype. These findings indicate that it underwent an osteoblast differentiation process. All these findings were more significant than when cells were grown on plastic, in the presence and absence of this osteogenic supplement, and were more evident when this supplement was present in the growth medium (GM). The ceramic evaluated herein was bioactive, cytocompatible and capable of promoting the proliferation and differentiation of undifferentiated ahMSCs into osteoblasts, which may be important for bone integration into the clinical setting.

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New evaluation of the in vitro response of silicocarnotite monophasic material

Cited by 31 publications

References 39 publications

In vitro bioactivity of glass-ceramic/fibroin composites

In vitro bioactivity of glass-ceramic/fibroin composites

A New Biphasic Dicalcium Silicate Bone Cement Implant

Assessment of Effects of Si-Ca-P Biphasic Ceramic on the Osteogenic Differentiation of a Population of Multipotent Adult Human Stem Cells

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