“…Word (1952) first drew attention to an increase in the ectopic pregnancy rate as a result of the widespread use of chemotherapy and antibiotics in the treatment of salpingitis. Krohn and Priver (1952) stated that, since the advent of penicillin, ectopic pregnancies in various areas had roughly doubled. Johnson (1952), Johnson and Post (1954) suggest that the modern treatment of pelvic infection often prevents complete closure of both tubes; there is therefore more often partial tubal obstruction, such as partial agglutination of mucosal folds; and this, together with the consequent altered local physiology, lends to hold up the fertilized ovum in the tube.…”