New epidemiological aspects of visceral and cutaneous leishmaniasis in Taza, Morocco

Hakkour, Maryam; Hmamouch, Asmae; Alem, Mohamed Mahmoud El; Rhalem, Abdelkbir; Amarir, Fatima; Touzani, Mohamed; Sadak, Abderrahim; Fellah, Hajiba; Sebti, Faiza

doi:10.1186/s13071-016-1910-x

Cited by 30 publications

(26 citation statements)

References 20 publications

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“…Our result is consistent with many studies; in Algeria (189 men and 197 women; sex ratio F/M: 1.04) [11]. Also in Taza, Morocco which found a slight in the CL prevalence between genders with predominance of CL in females (57 vs. 43% for men; sex-ratio F/M = 1.32) [12] and in another study, 44% male and 56% female patients were affected by CL [13].…”

Section: Cutaneous Leishmaniasis: Endemic Regions and Epidemiologicalsupporting

confidence: 93%

“…The results found in Morocco showed that no age group was spared from leishmaniasis [12], in another study patients' ages varied from 1.25 to 70 years [13].…”

Section: Distribution Of CL By Agementioning

confidence: 84%

“…Children aged 1 to 10 years lead with 48.13% of identified cases. This high percentage could be due to the sensitivity of the skin at this age, weak immune system and the nudity of children, making them more vulnerable to insect bites, and thus most affected by the leishmaniasis [12].…”

Section: Cutaneous Leishmaniasis In Childrenmentioning

confidence: 99%

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Cutaneous Leishmaniasis: Endemic Regions and Epidemiological Characteristics of Cases Declared at University Hospital Center of Tlemcen, Algeria, 2012-2016

Abdrebbi¹,

Henaoui²,

Chabni³

et al. 2019

JPP

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Cutaneous leishmaniasis (CL) is a widespread parasitic disease and a public health problem worldwide. It is an endemic and notifiable disease in Algeria. Our objective was to know the epidemiological characteristics and to determine the endemic regions of the CL in the town of Tlemcen. A descriptive study was conducted with a prospective collection over five years, from 2012 to 2016, based on the systematic declaration of CL cases received from the various departments of the University Hospital center (UHC) of Tlemcen. Data entry and analysis was done by Epi-info 6 software. Thirty-four cases of cutaneous leishmaniasis, 27 of which are autochthonous were reported at the UHC of Tlemcen during 5 years with a female predominance; sex ratio (h/f): 0.79. The most affected age group was 40-50 years old. Six cases occurred in children under 16 years, 80% of the reports were received by the dermatology department. The highest peak was recorded in 2013; autumnal predominance was noted in 30% of cases. All patients lived or had been in endemic areas. Vector control campaigns must be reinforced to fight against leishmaniasis in the town of Tlemcen, also, the improvement of habitat conditions for populations at risk.

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Section: Cutaneous Leishmaniasis: Endemic Regions and Epidemiologicalsupporting

confidence: 93%

“…The results found in Morocco showed that no age group was spared from leishmaniasis [12], in another study patients' ages varied from 1.25 to 70 years [13].…”

Section: Distribution Of CL By Agementioning

confidence: 84%

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Cutaneous Leishmaniasis: Endemic Regions and Epidemiological Characteristics of Cases Declared at University Hospital Center of Tlemcen, Algeria, 2012-2016

Abdrebbi¹,

Henaoui²,

Chabni³

et al. 2019

JPP

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“…Some sporadic cases of CL due to Leishmania infantum have also been described. 2 , 3 Cutaneous leishmaniasis scars on the face can cause considerable psychosocial suffering. In young women in North Africa and the Middle East, social rejection, diminished marriage and employment prospects, and suicidal thoughts have been documented.…”

Section: Introductionmentioning

confidence: 99%

Accuracy of a Rapid Diagnostic Test Based on Antigen Detection for the Diagnosis of Cutaneous Leishmaniasis in Patients with Suggestive Skin Lesions in Morocco

Bennis

Verdonck

Khalfaoui

et al. 2018

The American Journal of Tropical Medicine and Hygiene

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Abstract.In rural areas in Morocco, diagnosing cutaneous leishmaniasis (CL) can be challenging. We evaluated the accuracy of a rapid diagnostic test (RDT) based on antigen detection, CL Detect Rapid Test™ (Inbios International Inc., Seattle, WA), in this setting. We consecutively recruited patients with new skin ulcers in nine primary health centers. We took a dental broach sample for the RDT and two other tissue samples by scraping the border and center of the lesion with a scalpel and smearing it on a slide. We duplicated each smear by pressing a clean slide against it and processed the slides by microscopy, polymerase chain reaction (PCR) internal transcribed spacer 1, and kDNA minicircle PCR. In a subgroup with positive PCR, the Leishmania species was identified using PCR-restriction fragment length polymorphism and PCR-sequencing of hsp70 genes. A participant with positive microscopy and/or PCR was considered a confirmed CL case. We computed sensitivity (Se) and specificity (Sp) of the RDT compared with this reference standard (ClinicalTrials.gov registration: NCT02979002). Between December 2016 and July 2017, we included 219 patients, 50% of them were under 18 years old. Rapid diagnostic test Se was 68% [95% confidence interval (CI): 61–74], Sp 94% [95% CI: 91–97], positive predictive value 95% [95% CI: 92–98], and negative predictive value 64% [95% CI: 58–70]. Despite its low Se, this novel RDT is a useful addition to clinical management of CL in Morocco, especially in isolated localities. Rapid diagnostic test–positive lesions can be treated as CL; but when RDT negative, microscopy should be done in a second step. The Se of the RDT can probably be optimized by improving the sampling procedure.

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“…In central Morocco, L. tropica is the only agent responsible for CL cases in certain provinces [23]. In others, this species has been isolated alongside a few cases of L. infantum [24,25]. However, at Southwest, L. tropica is the only prominent species [13,26].…”

Section: Introductionmentioning

confidence: 99%

Cartography and Epidemiological Study of Leishmaniasis Disease in Sefrou Province (2007–2010), Central North of Morocco

Talbi

Khayyat

Omari³

et al. 2020

Interdisciplinary Perspectives on Infectious Diseases

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Increasing cases of leishmaniasis disease have been reported during recent years in Sefrou Province, Central North of Morocco. This study presents the epidemiological profile of the provincial population, aims at analyzing the epidemiological profile, and in particular, spatiotemporal follow-up of all cases of leishmaniasis. It is a retrospective analysis of leishmaniasis cases recorded between 2007 and 2010. The data were analyzed by SPSS software (version 20). Over a four-year period, from 2007 to 2010, there were 62 cases of leishmaniasis, 93.12% of cases of cutaneous leishmaniasis and 6.87% of visceral leishmaniasis. The case number of leishmaniasis in the Province of Sefrou varies between 0.165% and 0.0018%. For each type of leishmaniasis, the female sex was the most affected compared to the male sex. This difference cannot be considered statistically significant (χ2 = 0.083, p value = 0.77). For cutaneous leishmaniasis, all age groups were affected with a large percentage: patients aged 0–9 years with 63.11% followed by the age group [10–19] with 24.18%. Visceral leishmaniasis mainly has affected the infant population [0–9] with 83.33%. We have not observed any association between the age classes and the leishmaniasis type (χ2 = 6.20, p value = 0.4). From a spatial point of view, the majority of cases of leishmaniasis was reported in El Menzel region (67 cases) followed by Sefrou (64 cases) and Tazouta (38 cases). There is a statistically significant relationship between the type of leishmaniasis and the studied regions (χ2 = 52; p value <0.001). The study of the epidemiological profile of leishmaniasis cases may be useful in enlightening health authorities to develop screening, treatment, and control strategies to reduce the incidence rate of the disease. Other research studies can be conducted to the dynamics of the vectors of sandflies and their ecology.

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New epidemiological aspects of visceral and cutaneous leishmaniasis in Taza, Morocco

Cited by 30 publications

References 20 publications

Cutaneous Leishmaniasis: Endemic Regions and Epidemiological Characteristics of Cases Declared at University Hospital Center of Tlemcen, Algeria, 2012-2016

Cutaneous Leishmaniasis: Endemic Regions and Epidemiological Characteristics of Cases Declared at University Hospital Center of Tlemcen, Algeria, 2012-2016

Accuracy of a Rapid Diagnostic Test Based on Antigen Detection for the Diagnosis of Cutaneous Leishmaniasis in Patients with Suggestive Skin Lesions in Morocco

Cartography and Epidemiological Study of Leishmaniasis Disease in Sefrou Province (2007–2010), Central North of Morocco

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