New ent-clerodane-type diterpenoids from Baccharis trimera

Herz, Werner; Pilotti, A.-M.; Söderholm, Anne Charlotte; Shuhama, Ilda Kazumi; Vichnewski, Walter

doi:10.1021/jo00444a026

Cited by 79 publications

(20 citation statements)

References 6 publications

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“…The planar structure was also supported by other HMBC correlations (Fig. 2) 17,18) indicating that the absolute structure of 1 was the same as that of 2. From these results, the structure of 1 was finally concluded to be (5S,8R,9R,10R)-8-hydroxy-7-oxo-ent-clerodan-3,13-dien-18,19:15,16-diolide (Fig.…”

Section: Resultssupporting

confidence: 55%

“…14) Isoschaftoside (10, 0.0542%) 15) and rutin (11, 0.0129%) 16) were isolated from the n-BuOH-soluble fraction by Toyopearl HW-40 (H 2 O/MeOH), Sephadex LH-20 (H 2 O/MeOH) and MCI-gel CHP20 (H 2 O/MeOH) CC. An attempt to separate Dragendorff's reagent positive compounds in the EtOH extract resulted in isolation of two known ent-clerodane diterpenes (2, 3, bitter taste, 0.0972, 0.0112%, respectively), 17,18) as described in experimental section. 2 and 3 were identified by comparing their spectroscopic data with values in the literatures (Table 1).…”

Section: Resultsmentioning

confidence: 99%

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A New ent-Clerodane Diterpene from the Aerial Parts of Baccharis gaudichaudiana.

Akaike

Sumino

Sekine

et al. 2003

CHEMICAL & PHARMACEUTICAL BULLETIN

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A new ent-clerodane diterpene, named bacchariol (1) was isolated from the aerial parts of Baccharis gaudichaudiana DC. (Compositae), together with known ent-clerodane diterpenes (2, 3), eight known flavonoids (4-11) and 3,5-dicaffeoylquinic acid (12). Their structures were determined by spectroscopic analyses. Flavonoids (7, 8, 11) and 12 showed moderate scavenging activities toward 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals.

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Section: Resultssupporting

confidence: 55%

Section: Resultsmentioning

confidence: 99%

A New ent-Clerodane Diterpene from the Aerial Parts of Baccharis gaudichaudiana.

Akaike

Sumino

Sekine

et al. 2003

CHEMICAL & PHARMACEUTICAL BULLETIN

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“…Essa correlação pode ser feita, devido à grande quantidade de cumarina (1,2-benzopirona), triterpenos/esteroides, e heterosídeos flavonoides na sua composição química encontrados por Bolina et al (2009), bem como alcaloides, saponinas, taninos, e polifenóis, relatados por Oliveira et al (1984). Essas substâncias são compartilhadas por muitas espécies do gênero (Silva Júnior et al, 1994;Martins et al, 1998;Fierro et al, 1999;Taleb-Contini et al, 2006) e outras, como os triterpenos (Herz et al, 1977;Bohlmann et al, 1978;Boeker et al, 1987;Castro et al, 1989;D 'Agostino et al, 1990;Oliveira et al, 2006) são encontradas tanto em M. glomerata como em M. cordifolia.…”

Section: Discussionunclassified

“…cordifolia, bem como outras espécies de Mikania de hábito trepador, são popularmente conhecidas como "guaco" e têm sido utilizadas como anti-inflamatório, anti-asmático, anti-parasitário, antireumático, febrífugo, analgésico (Lorenzi & Matos, 2000) para o tratamento de problemas respiratórios (Caribe & Campos, 1991), e para picadas de cobra (Caribe & Campos, 1991;Mors et al, 2000). Para a referida espécie, tem sido descrita a presença de diterpenos, sesquiterpenos e fenilpropanóides (Herz et al, 1977;Bohlmann et al, 1978;Boeker et al, 1987;Castro et al, 1989;D 'Agostino et al, 1990). Estudos farmacológicos in vitro com dois ácidos cafeoilquínicos isolados dessa planta também revelaram atividade antiinflamatória (Peluso et al, 1995), vale ressaltar que dentre as atividades biológicas descritas para M.cordifolia incluem-se as antitricomônica, antitripanossômica e inseticida (Arias et al, 1995;Serrano et al, 2000).…”

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Efeito genotóxico e antiproliferativo de Mikania cordifolia (L. F.) Willd. (Asteraceae) sobre o ciclo celular de Allium cepa L.

Dias

Canto-Dorow

Coelho

et al. 2014

Rev. bras. plantas med.

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INTRODUÇÃOAs plantas com potencial medicinal têm sido muito utilizadas para o tratamento de doenças no Brasil, sendo, algumas vezes, o único medicamento disponível à população (Fachinetto & Tedesco, Efeito genotóxico e antiproliferativo de Mikania cordifolia (L. For each one, two treatments were prepared in different concentrations: 4g/500mL and 16g/500mL. A positive control consisting of 10% glyphosate in 90% water, which is an herbicide widely used and known for its genotoxic potential, was also prepared. Distilled water was used as negative control. After a 24-hour period, the infusion of the root tips was collected, fixed in ethanol-acetic acid (3:1) for 24 hours and stored in 70% ethanol. Cells were analyzed in all phases of the cell cycle of A. cepa, a total of 2500, for each group of bulbs. The mitotic index (MI) was calculated and statistically analyzed by the c 2 test at 5%. Results showed that, in both populations of M. cordifolia, a reduction of the MI in all treatments compared with the negative control was observed. In both populations, an increase in the mitotic index values was obtained with increasing concentration of the infusion. Chromosomal aberrations were observed in both populations studied. In conclusion, infusions of M. cordifolia possess antiproliferative and mutagenic effects for the concentrations tested on the cell cycle of A. cepa.

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“…B. genistelloides, flavones named eupatrin 2a, cirsimaritin 2b, cirsiliol 2c, hispidulin 2d and genkwanin 2e, together with the known apigenin 2f were isolated. [7][8][9][10] It is thought that these flavones are the major active substances in this plant. Quercetin 2g, luteolin 2h, and nepetin 2i also have been found.…”

Section: Introductionmentioning

confidence: 99%

New constituents of Baccharis genistelloides (Lam.) Pers.

Hennig¹,

Garcia²,

Giannis³

et al. 2010

Arkivoc

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A phytochemical investigation of the constituents of the aerial parts of Baccharis genistelloides has resulted in the isolation of the new piquerol derivative (E)-4-acetoxy-6-methylene-5-(prop-1-en-2-yl)cyclohex-2-enyl 2-methylbut-2-enoate 4, along with two other compounds [foliasalacin A 4 5, and (E)-icosyl 3-(4-hydroxy-3-methoxyphenyl)-acrylate 6], which have not been reported as constituents of this plant until now.

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New ent-clerodane-type diterpenoids from Baccharis trimera

Cited by 79 publications

References 6 publications

A New ent-Clerodane Diterpene from the Aerial Parts of Baccharis gaudichaudiana.

A New ent-Clerodane Diterpene from the Aerial Parts of Baccharis gaudichaudiana.

Efeito genotóxico e antiproliferativo de Mikania cordifolia (L. F.) Willd. (Asteraceae) sobre o ciclo celular de Allium cepa L.

New constituents of Baccharis genistelloides (Lam.) Pers.

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