New endoscopic method for gastric hypersensitivity testing: Pilot study

Momma, Eri; Koeda, Mai; Tanabe, Tomohide; Kanai, Shigeru; Hoshikawa, Yoshimasa; Hoshino, Shintaro; Kawami, Noriyuki; Kaise, Mitsuru; Iwakiri, Katsuhiko

doi:10.1002/jgh3.12544

Cited by 1 publication

(8 citation statements)

References 25 publications

(35 reference statements)

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“…Consistent with our previous findings [ 8 ], we demonstrated that the initial symptoms occurred with a lower gastric pressure and a smaller CO 2 injection volume in the drug-resistant FD patients than in non-FD patients. Similarly, bothersome symptoms occurred with a lower gastric pressure and a smaller CO 2 injection volume in the drug-resistant FD patients.…”

Section: Discussionsupporting

confidence: 93%

“…Drug-resistant FD is defined as the presence of at least 1 symptom of dyspepsia other than “belching” on the revised F scale [ 9 ] with a score of 4 points (frequency of symptoms: always) or at least 1 symptom of dyspepsia other than “belching” with a score >3 points (frequency of symptoms: often) and a total dyspepsia symptom score >8 points [ 8 ]. Non-FD is defined as a dyspepsia score ≤1 (frequency of symptoms: occasionally) and a total dyspepsia symptom score, excluding “belching”, ≤3 points [ 8 ].…”

Section: Methodsmentioning

confidence: 99%

“…Breathing was shallow and basal gastric pressure was assessed as the intermediate pressure of breathing in a stable state. The air supply button was repeatedly pressed to deliver a continuous injection of CO 2 at a constant speed, and gastric pressure and the CO 2 injection volume were assessed [ 8 ]. Gastric pressure and CO 2 injection volume measurements are outlined in Fig 1 .…”

Section: Methodsmentioning

confidence: 99%

“…Data were stored on a PC. Instructions were given to patients to indicate any sensation of upper abdominal tension during the CO 2 injection by lifting their right hand, at which point gastric pressure and the volume of CO 2 injected were recorded [ 8 ].…”

Section: Methodsmentioning

confidence: 99%

“…However, there is currently no routine method for evaluating gastric motility dysfunction or gastric hypersensitivity. In our previous study, we developed a method to measure gastric pressure and the CO 2 injection volume while injecting CO 2 during endoscopy, and demonstrated that, initial upper abdominal symptoms after CO 2 injection develop with significantly lower gastric pressure and CO 2 volume in drug-resistant FD patients who are strongly suspected of having gastric hypersensitivity [ 8 ], compared with non-FD patients. We also reported that the sensitivity and specificity to drug-resistant FD were 81.5% and 81.5%, respectively, with a cut-off gastric pressure of 12.7 mmHg.…”

Section: Introductionmentioning

confidence: 99%

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Smaller CO2 injection volume and lower gastric pressure induce bothersome symptoms in drug-resistant functional dyspepsia patients with less frequent belching

et al. 2022

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Background The relationship between bothersome symptoms and gastric pressure or CO2 injection volumes in drug-resistant functional dyspepsia (FD) patients remains unknown; therefore, this relationship was examined in drug-resistant FD and non-FD patients. Methods Thirty drug-resistant FD patients and 30 non-FD patients were recruited. Gastric pressure was assessed using an external pressure transducer, and the CO2 injection volume was measured using an endoscopic CO2-supplied device and flow meter. The following variables were examined: gastric pressure at baseline and gastric pressure and the CO2 injection volume when patients initially felt abdominal tension and bothersome symptoms following the CO2 injection. The relationship between belching and bothersome symptoms was also investigated. Results No significant differences were observed in basal gastric pressure between the groups. Initial and bothersome symptoms in the upper abdomen in drug-resistant FD patients developed at a significantly lower gastric pressure and significantly smaller CO2 injection volume than in non-FD patients. The frequency of belching was significantly lower in the drug-resistant FD group than in the non-FD group. Conclusion Bothersome symptoms in drug-resistant FD patients develop at a lower gastric pressure and smaller CO2 injection volume than in non-FD patients. These patients also had difficulties with belching.

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Section: Discussionsupporting

confidence: 93%