New Enantiospecific Synthesis of (+)-(2R,6R)-(+)-2,6,10-Trimethylundecan-1-ol for Constructing the Side Chain of Natural (2R,4′R,8′R)-(+)-α-Tocopherol (Vitamin E)

New method for the synthesis of (3R,7R)-hexahydrofarnesyl bromide based on the microwave-activated regioselective enolization of homochiral phytone

“…The extract was washed with brine, dried with MgSO 4 , and concentrated to obtain acid 5 (0.18 g, 58%) as viscous colorless oil, which was identical to the sample described in Ref. 32 B. An ozone-oxygen mixture was bubbled through a mix ture of enol acetate 3 (0.14 g, 0.45 mmol), Ba(OH) 2 (0.12 g, 0.7 mmol), and acetone (8 mL) for 2 min at 30 L h -1 (1.0 mmol of О 3 ) followed by the bubbling of Ar.…”