New Emivirine (MKC‐442) Analogues Containing a Tetrahydronaphthalene at C‐6 and Their anti‐HIV Activity.

Abstract

New Emivirine (MKC-442) Analogues Containing a Tetrahydronaphthalene at C-6 and Their anti-HIV Activity. -Synthesis and testing of the inhibitory activity concerning the HIV-1 replication are given. Only the emivirine analogues (VII) show moderate activity against wild-type HIV-1 and against the Y181C mutant whereas (XV) is devoid of activity against HIV. -(THERKELSEN, F.; JOERGENSEN, P. T.; NIELSEN, C.; PEDERSEN*, E. B.; Monatsh. Chem. 138 (2007) 5, 495-503; Dep. Chem., Univ. South. Den., DK-5230 Odense, Den.; Eng.) -H. Haber 35-196

Synthesis of Novel Derivatives Bearing Heterocycles-Tetrahydronaphthalene Conjugates for Antimicrobial and Antiviral Evaluation

“…1). Additionally, Nafcillin clinically applied as antimicrobial activity (33,34) and literature survey exhibited that some of the synthesized derivatives comprising tetrahydronaphthalene ring such as compounds A (11) and B (35) produced significant antimicrobial activities (Fig. 2).…”

“…There are several reports in the literature describing the tetrahydronaphthalene derivatives for their various pharmacological activities, including action as nonsteroidal glucocorticoid receptor modulators (5) , anticancer (6)(7)(8) , antimicrobial (9) , antifungal (10) and anti-HIV (11,12) . The thiazolidinones ring with C-2 and N-3 substituted positions has been incorporated into a broad range of known biologically active compounds as antimicrobial (13) , anti-inflammatory (14) , anticancer and antiviral activity (15) .…”