New efficient synthesis of bis-1,2,4-oxadiazole derivatives via subsequent Staudinger/aza-Wittig reaction

Abstract

A convenient route for the synthesis of bis-1,2,4-oxadiazoles is described. One-pot reaction of diazidoglyoxime esters and triphenylphosphine produced bis-1,2,4-oxadiazole derivatives in good overall yields by subsequent Staudinger/aza-Wittig reaction. All compounds were characterized by IR, 1 HNMR, 13 CNMR and HRMS and the structure of key product was unequivocally confirmed by X-ray diffraction analysis.