SynopsisFive general routes for the preparation of polyoxyethylene [generally referred to as poly(ethy1ene glycol) or PEG] derivatives are described. These routes are (1) nucleophilic displacements with the alkoxide of PEG, (2) nucleophilic displacement on PEG-tosylate, -mesylate, or -bromide, (3) reductive amination of PEG-aldehyde, (4) reductive amination of PEG-amine, and (5) nucleophilic displacements on the s -triazine derivative prepared from s-triazine trichloride (cyanuric chloride) and PEG. Eighteen derivatives are prepared and potential applications to catalysis, cell purifications, and other areas are discussed briefly.