1980
DOI: 10.1021/jo01314a032
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New, easily removable poly(ethylene glycol) supports for the liquid-phase method of peptide synthesis

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Cited by 128 publications
(53 citation statements)
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“…PEG-bisamine (PEGBA), which is PEG with amino groups in both ends, was prepared from PEG-1450 according to the method described by Pillai et al [14].…”
Section: Preparation Of Modified Pegmentioning
confidence: 99%
“…PEG-bisamine (PEGBA), which is PEG with amino groups in both ends, was prepared from PEG-1450 according to the method described by Pillai et al [14].…”
Section: Preparation Of Modified Pegmentioning
confidence: 99%
“…In our route, derivative la was obtained with very little chain degradation by sodium hydride generation of PEG-alkoxide and subsequent reaction with p-toluene sulfonyl chloride, eq. (2)'": PEG-CH20H 2 PEG-CH20-Na+ PEG-CH20Ts (2) Unlike the tosylate, which is prone to decomposition upon extended storage, the mesylate [eq. were found to be stable upon storage.…”
Section: Pegchz-nhrmentioning
confidence: 99%
“…First, Aminomonomethoxy poly (ethy1ene glycol)(MPEG-NH 2 ) was synthesized based on the principle of Gabriel synthesis. The detailed reaction and purification conditions could be found in Pillia's manuscript (PILLAI et al, 1980). Then, L-alanine-N-carboxvanhvdride(L-Alanine-NCA) was prepared by the following method: L-Alanine(5g) was put into a three-neck flask and dissolved in tetrahydrofuran (50ml).…”
Section: Synthesis Of Plammentioning
confidence: 99%