New dual-energy X-ray absorptiometry equipment in the assessment of vertebral fractures: technical limits and software accuracy

Bazzocchi, Alberto; Diano, Danila; Battista, Giuseppe; Albisinni, Ugo; Rossi, Cristina; Guglielmi, Giuseppe

doi:10.1007/s00256-011-1302-4

Cited by 5 publications

(3 citation statements)

References 24 publications

(28 reference statements)

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“…Furthermore, the accuracy of in vivo LAT DXA is influenced not only by the patient positioning but also by the heterogeneous nature of soft tissue surrounding the spine and higher X-ray beam attenuation related to the greater soft tissue volume in LAT geometry compared to AP geometry [30]. On the other hand, Vertebral Fracture Assessment (VFA) software of the new generation of densitometers [35, 36] can be utilized for precise and reliable assessment of vertebral geometry in AP and LAT views of the thoracic and lumbar spine.…”

Section: Discussionmentioning

confidence: 99%

The Ratio of Anterior and Posterior Vertebral Heights Reinforces the Utility of DXA in Assessment of Vertebrae Strength

et al. 2014

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The objective of the study was to introduce a new parameter describing bone strength with greater precision than the widely used antero-posterior DXA (dual-energy X-ray absorptiometry), which measures areal bone mineral density (aBMD). The adjusted areal bone mineral density (AaBMD) defined as the ratio between aBMD and ha/hp (ha and hp: anterior and posterior vertebral body heights measured on the lateral view, respectively) is proposed: AaBMD = aBMD/(ha/hp). The utility of AaBMD in prediction of bone strength was assessed by in vitro measurements of cadaver L3 vertebrae. The AaBMD of 31 vertebrae was correlated with the ultimate stress (Pmax) and load (Fmax) values obtained in mechanical tests. The correlations were compared to those obtained for aBMD and for volumetric bone mineral density (vBMD) measured by computed tomography. The correlation of AaBMD to Fmax adjusted for donor’s age was significantly higher than for aBMD and vBMD (r = 0.740, 0.658, and 0.609, respectively, p < 0.05). The differences between partial correlation coefficients for Pmax to AaBMD, aBMD and vBMD relationships were smaller (r = 0.764, 0.720, and 0.732, respectively, p < 0.05), but also showed the superiority of AaBMD. Combining antero-posterior DXA aBMD and the lateral ha/hp ratio, measured, for example, by the Vertebral Fracture Assessment software of the new generation of DXA devices, seems to accurately predict the mechanical vertebral parameters related to bone strength. It is assumed that the proposed AaBMD parameter may be more predictive for fracture risk assessment, which requires further studies.

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Section: Discussionmentioning

confidence: 99%

The Ratio of Anterior and Posterior Vertebral Heights Reinforces the Utility of DXA in Assessment of Vertebrae Strength

et al. 2014

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“…Women with a pre-existing VF suffer a 4-to 5-fold increase risk of sustaining a new incident VF; this risk increases with the number of prevalent fractures at the baseline and was proved to be BMDindependent (194,197). Conventional radiography and DXA represent the techniques of choice for VFs detection (198)(199)(200). Radiologic methods for the identification and the scoring of VFs include quantitative morphometry (QM), the visual semiquantitative (SQ) method and the "algorithmbased qualitative" (ABQ) method (8).…”

Section: Vfs Assessmentmentioning

confidence: 99%

Quantitative imaging techniques for the assessment of osteoporosis and sarcopenia

Guerri

Mercatelli

Gómez

et al. 2018

Quant. Imaging Med. Surg.

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106

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Bone and muscle are two deeply interconnected organs and a strong relationship between them exists in their development and maintenance. The peak of both bone and muscle mass is achieved in early adulthood, followed by a progressive decline after the age of 40. The increase in life expectancy in developed countries resulted in an increase of degenerative diseases affecting the musculoskeletal system. Osteoporosis and sarcopenia represent a major cause of morbidity and mortality in the elderly population and are associated with a significant increase in healthcare costs. Several imaging techniques are currently available for the non-invasive investigation of bone and muscle mass and quality. Conventional radiology, dual energy X-ray absorptiometry (DXA), computed tomography (CT), magnetic resonance imaging (MRI) and ultrasound often play a complementary role in the study of osteoporosis and sarcopenia, depicting different aspects of the same pathology. This paper presents the different imaging modalities currently used for the investigation of bone and muscle mass and quality in osteoporosis and sarcopenia with special emphasis on the clinical applications and limitations of each technique and with the intent to provide interesting insights into recent advances in the field of conventional imaging, novel high-resolution techniques and fracture risk.

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“…A few studies have focused on the reliability and accuracy of such software in different settings. [66][67][68][69][70] In a few cases these were advocated as useful tools in differentiating normal vertebral shape from mild fractures, with higher overall accuracy and precision on normal vertebrae and mild fractures. 71 The approach with artificial neural networks was proposed as a further opportunity to recognize VFs, and it showed good performance in identifying both spinal defor-mity index 1 and 5, proposed in the development of an algorithm for predicting fractures.…”

Section: What Is the Impact Of Vertebral Fractures?mentioning

confidence: 99%

Vertebral Fracture Identification

Bazzocchi

Guglielmi

2016

Semin Musculoskelet Radiol

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When bone becomes frail due to metabolic disorders, one or more vertebral fractures (VFs) may occur. A vertebral body fracture after minor trauma is a hallmark of osteoporosis. VFs represent a target in clinical practice and are often an endpoint in clinical trials. The health care and economic burden of VFs is huge, and they also significantly increase mortality and morbidity, as well as impairing function and quality of life. VFs are frequently clinically silent, thus imaging plays a role not only after symptoms appear but also in screening. A VF can be detected incidentally during imaging examinations performed for different clinical indications. A rapid look at the spine included in the scanned field may lead to the discovery of a VF, which must be reported because the event may change the management of the patient and prevent further problems, defusing the so-called vertebral fracture cascade. This review article focuses on VF awareness and identification to answer these questions: What is a VF? What is the impact of VFs? How can we detect VF?

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New dual-energy X-ray absorptiometry equipment in the assessment of vertebral fractures: technical limits and software accuracy

Abstract: This study provides new and interesting information about the accuracy, reliability, and imaging quality provided by iDXA in the assessment of VFs.

Cited by 5 publications

References 24 publications

The Ratio of Anterior and Posterior Vertebral Heights Reinforces the Utility of DXA in Assessment of Vertebrae Strength

The Ratio of Anterior and Posterior Vertebral Heights Reinforces the Utility of DXA in Assessment of Vertebrae Strength

Quantitative imaging techniques for the assessment of osteoporosis and sarcopenia

Vertebral Fracture Identification

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