New drug approvals for 2022: Synthesis and clinical applications

Yuan, Shuofeng; Shen, Dan‐Dan; Jia, Rui; Sun, Jinlei; Song, Jian; Liu, Hong‐Min

doi:10.1002/med.21976

Cited by 16 publications

(3 citation statements)

References 159 publications

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“…This is of great value for the development of new drugs and the improvement of existing drug regimens. Safety and toxicological assessment: Understanding the safety and possible side effects of P. ternata is essential to ensuring its safety in clinical applications (Yuan et al, 2023). The study of the toxicological properties of P. ternata can help guide its rational use in medical practice.…”

Section: Significance Of Studying Pinellia Ternatamentioning

confidence: 99%

Unveiling terahertz wave stress effects and mechanisms in Pinellia ternata: Challenges, insights, and future directions

Wang,

Zheng,

Sarsaiya

et al. 2024

Physiologia Plantarum

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This review aims to elucidate the intricate effects and mechanisms of terahertz (THz) wave stress on Pinellia ternata, providing valuable insights into plant responses. The primary objective is to highlight the imperative for future research dedicated to comprehending THz wave impacts across plant structures, with a specific focus on the molecular intricacies governing root system structure and function, from shoots to roots. Notably, this review highlights the accelerated plant growth induced by THz waves, especially in conjunction with other environmental stressors, and the subsequent alterations in cellular homeostasis, resulting in the generation of reactive oxygen species (ROS) and an increase in brassinosteroids. Brassinosteroids are explored for their dual role as toxic by‐products of stress metabolism and vital signal transduction molecules in plant responses to abiotic stresses. The paper further investigates the spatio‐temporal regulation and long‐distance transport of phytohormones, including growth hormone, cytokinin, and abscisic acid (ABA), which significantly influence the growth and development of P. ternata under THz wave stress. With a comprehensive review of Reactive oxygen species (ROS) and Brassinosteroid Insensitive (BRI) homeostasis and signalling under THz wave stress, the article elucidates the current understanding of BRI involvement in stress perception, stress signalling, and domestication response regulation. Additionally, it underscores the importance of spatio‐temporal regulation and long‐distance transport of key plant hormones, such as growth hormone, cytokinin, and ABA, in determining root growth and development under THz wave stress. The study of how plants perceive and respond to environmental stresses holds fundamental biological significance, and enhancing plant stress tolerance is crucial for promoting sustainable agricultural practices and mitigating the environmental burdens associated with low‐tolerance crop cultivation.

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Section: Significance Of Studying Pinellia Ternatamentioning

confidence: 99%

Unveiling terahertz wave stress effects and mechanisms in Pinellia ternata: Challenges, insights, and future directions

Wang,

Zheng,

Sarsaiya

et al. 2024

Physiologia Plantarum

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“…[2] The discovery of new drugs relies heavily on the structural diversity and innovation provided by small molecules. [3] Therefore, merging spirocyclic lactam and aza-spiropyrazolone architectures to generate structurally intriguing spiropyrazolone-lactam frameworks could provide a potent strategy for identifying promising drug candidates. [2c,4d] However, research focused on constructing such valuable nitrogen-enriched spirocyclic structures has been minimal compared to the more extensively studied spirocyclic lactams and aza-spiropyrazolones.…”

Section: Introductionmentioning

confidence: 99%

[3+2] Cycloaddition of Rationally Designed Trisubstituted Cyclic α‐Chloroamide: an Alternative Strategy for Accessing Spirocyclic γ‐Lactam Architecture

Li,

Zuo,

Chen

et al. 2023

Adv Synth Catal

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Here we present a [3+2] cycloaddition of rationally designed trisubstituted cyclic α‐chloroamides, primarily those incorporating pharmacological pyrazolone cores, as potent synthons for synthesizing valuable spirocyclic γ‐lactam architectures. This protocol exhibits 52–96% yields, impressive substrate compatibility, and scale‐up capacity. Importantly, this study also represents one of the rare examples that harness enaminone C−N bond cleavage to engineer relevant spirocyclic γ‐lactam skeletons of biological interest. Moreover, we propose a plausible mechanistic explanation to elucidate the outstanding chemical outcomes observed, thereby enriching the synthetic toolbox for pyrazolone chemistry and α‐haloamide‐mediated reactions.

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“…Как известно все новые ЛС можно условно поделить на: содержащие малые молекулы или препараты, созданные на основании биологического подхода. При этом широкое распространение биотехнологии до недавнего времени ограничивалось уровнем развития технологий и стоимостью, но при этом практически все участники сходились во мнении, что биотехнология рано или поздно предоставит больше возможностей для фармацевтической разработки, чем медицинская химия [16][17][18]. В то же время разработка лекарств на основе химического синтеза и медицинская химия как наука претерпели и продолжают претерпевать ряд существенных изменений.…”

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Methodological and regulatory aspects of pharmaceutical development of biological products

Kurkin,

Morkovin,

Bakulin

et al. 2024

Farm. farmakol. (Pâtigorsk)

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The aim of the work was to conduct an analysis of the current state and current trends in the approval of drugs, as well as some aspects of the methodology for their development based on biological molecules and registration.Materials and methods. The material for the analysis was taken from the abstract databases of PubMed, Google Scholar and e-library.ru. The search was carried out using publications for the period from 2008 to 2023, the keywords were as follows: “biologicals”, “new drug approval”, “drug authorization”, “drug development”, “biosimilar”, taking into account various spellings.Results. Over the past 15 years, scientists have been observing revolutionary trends and processes in the field of the drug development, especially biopharmaceuticals. Significant advances have been made in gene, immune and cell therapies, resulting in the approval of such drugs more than doubling over the past ten years. The development of biological drugs includes the identification and testing of molecular targets and requires a deep understanding of the structure and functioning of the polypeptides involved in the development of the effect. The features of these active pharmaceutical substances are a high molecular weight, a complex three-dimensional structure and a high immunogenic potential. Preclinical and clinical studies of biologics have unique challenges. Selecting appropriate animal species, understanding the immunogenicity, and assessing pharmacodynamics and toxicological properties require a multilevel, detailed approach. The article discusses the regulatory framework under which these drugs are registered, summarizing the guidelines provided by international organizations such as the International Council for Harmonization and various national agencies.Conclusion. The analysis highlights the current advances and prospects in the development of biologics, highlighting their key role in future transformations in the treatment of rare diseases and oncology, approaching the era of personalized medicine. Monitoring the development directions and technological approaches, as well as the commitment to global methodological and regulatory aspects can become a catalyst in the development of the Russian pharmacology.

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New drug approvals for 2022: Synthesis and clinical applications

Cited by 16 publications

References 159 publications

Unveiling terahertz wave stress effects and mechanisms in Pinellia ternata: Challenges, insights, and future directions

Unveiling terahertz wave stress effects and mechanisms in Pinellia ternata: Challenges, insights, and future directions

[3+2] Cycloaddition of Rationally Designed Trisubstituted Cyclic α‐Chloroamide: an Alternative Strategy for Accessing Spirocyclic γ‐Lactam Architecture

Methodological and regulatory aspects of pharmaceutical development of biological products

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