New dosages and formulations of AEDs for use in pediatric epilepsy

Clinical experience with topiramate dosing and serum levels in patients with epilepsy

“…28,29,37,38 Higher mg per kg dosages may be necessary in children and infants because of increased TPM clearance rates. 2,[6][7][8][9][10] The relationship between TPM dose and efficacy has been well established from several clinical trials. [11][12][13][14][15] On the other hand, the relationship between TPM SL and clinical course has not been so widely investigated.…”