New Discoveries in Radiation Science

Sáfrány, Géza; Lumniczky, Katalin; Manti, Lorenzo

doi:10.3390/cancers13051034

Cited by 2 publications

(2 citation statements)

References 17 publications

(27 reference statements)

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“…However, LDIR may increase incidences of vascular diseases, cognitive and mental health disorders, eye diseases, and other pathologies, whilst reducing cancer mortality and mutations, and increasing longevity [170]. Despite more studies beginning to investigate radiosensitivity [171], it remains unclear what effect LDIR truly has on different organs or tissues. One important effect which cannot be ignored is the potential effect of LDIR on cellular senescence.…”

Section: Figurementioning

confidence: 99%

“…Recently, rat models of AD were also shown to have improved memory performance in response to a higher dose of ionising radiation of 2 Gy/day for 5 days, without increasing neuroinflammation or amyloid load [170]. LDIR has also been shown to promote an M2 morphology in LPS treated mice microglial (BV2) cells [171].…”

Section: Impact Of Low Dose Ionising Radiation On Neurodegenerative Diseasesmentioning

confidence: 99%

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Control of Neuroinflammation through Radiation-Induced Microglial Changes

Boyd

Byrne

Middleton

et al. 2021

Cells

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Microglia, the innate immune cells of the central nervous system, play a pivotal role in the modulation of neuroinflammation. Neuroinflammation has been implicated in many diseases of the CNS, including Alzheimer’s disease and Parkinson’s disease. It is well documented that microglial activation, initiated by a variety of stressors, can trigger a potentially destructive neuroinflammatory response via the release of pro-inflammatory molecules, and reactive oxygen and nitrogen species. However, the potential anti-inflammatory and neuroprotective effects that microglia are also thought to exhibit have been under-investigated. The application of ionising radiation at different doses and dose schedules may reveal novel methods for the control of microglial response to stressors, potentially highlighting avenues for treatment of neuroinflammation associated CNS disorders, such as Alzheimer’s disease and Parkinson’s disease. There remains a need to characterise the response of microglia to radiation, particularly low dose ionising radiation.

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Section: Figurementioning

confidence: 99%

Section: Impact Of Low Dose Ionising Radiation On Neurodegenerative Diseasesmentioning

confidence: 99%

Control of Neuroinflammation through Radiation-Induced Microglial Changes

Boyd

Byrne

Middleton

et al. 2021

Cells

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Coronary Computed Tomography vs. Cardiac Magnetic Resonance Imaging in the Evaluation of Coronary Artery Disease

et al. 2022

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Coronary artery disease (CAD) represents a widespread burden to both individual and public health, steadily rising across the globe. The current guidelines recommend non-invasive anatomical or functional testing prior to invasive procedures. Both coronary computed tomography angiography (cCTA) and stress cardiac magnetic resonance imaging (CMR) are appropriate imaging modalities, which are increasingly used in these patients. Both exhibit excellent safety profiles and high diagnostic accuracy. In the last decade, cCTA image quality has improved, radiation exposure has decreased and functional information such as CT-derived fractional flow reserve or perfusion can complement anatomic evaluation. CMR has become more robust and faster, and advances have been made in functional assessment and tissue characterization allowing for earlier and better risk stratification. This review compares both imaging modalities regarding their strengths and weaknesses in the assessment of CAD and aims to give physicians rationales to select the most appropriate modality for individual patients.

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New Discoveries in Radiation Science

Abstract: This series of 16 articles (8 original articles and 8 reviews) was written by internationally recognized scientists attending the 44th Congress of the European Radiation Research Society (Pécs, Hungary) [...]

Cited by 2 publications

References 17 publications

Control of Neuroinflammation through Radiation-Induced Microglial Changes

Control of Neuroinflammation through Radiation-Induced Microglial Changes

Coronary Computed Tomography vs. Cardiac Magnetic Resonance Imaging in the Evaluation of Coronary Artery Disease

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