New Directions in the Fight against Cancer: From Metal Complexes to Nanostructured Materials

Gómez‐Ruiz, Santiago

doi:10.1002/9783527645787.ch10

Cited by 5 publications

(2 citation statements)

References 333 publications

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“…For this reason, the scientific community has now focused its efforts on the design of novel therapeutic technologies mainly based on nanostructured materials, which may act as vectors for the delivery of the metallodrug or simply as a protector of the active species for the enhancement of its anti‐cancer action 8. 9…”

Section: Introductionmentioning

confidence: 99%

Anti‐cancer Applications of Titanocene‐Functionalised Nanostructured Systems: An Insight into Cell Death Mechanisms

Ceballos-Torres

Virág

Cenariu

et al. 2014

Chemistry A European J

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A series of alkenyl-substituted titanocene compounds have been supported on the mesoporous silica-based material KIT-6. The corresponding functionalised materials were completely characterised by different techniques (solid-state multinuclear NMR spectroscopy, IR spectroscopy, N2 adsorption-desorption isotherms, X-ray fluorescence and diffraction, SEM and TEM) to observe the incorporation of the titanocene derivatives on the external surface of the material KIT-6. Both the titanocene compounds and the materials were tested in vitro against a wide variety of human cancer and normal cell lines. A very high cytotoxicity of the synthesised titanocene derivatives (IC50 values in the range of those described in the literature for the most active cytotoxic titanocene compounds), with selectivity towards cancer cell lines was observed. The cytotoxic activity of the materials is the highest reported to date for titanocene-functionalised materials. In addition, higher Ti uptake (from 4 to 23% of the initial amount of Ti) of the cells treated with materials was observed with respect to those treated with "free" titanocene derivatives (which gave Ti uptake values from 0.4 to 4.6% of the initial amount of Ti). Additional experiments with the titanocene derivatives and the functionalised materials revealed that changes to the morphological and functional dynamics of apoptosis occurred when the active titanocene species were incorporated into mesoporous materials. In addition, the materials could induce programmed cell death in tumour cell populations by impairing the damaged DNA repair mechanisms and by upregulation of intrinsic and extrinsic apoptotic signalling pathways.

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Section: Introductionmentioning

confidence: 99%

Anti‐cancer Applications of Titanocene‐Functionalised Nanostructured Systems: An Insight into Cell Death Mechanisms

Ceballos-Torres

Virág

Cenariu

et al. 2014

Chemistry A European J

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“…In addition, the strength of the interaction between a drug and DNA is directly related to antitumor capacity; therefore, careful characterization of potent compounds provides vital information for the design and synthesis of new compounds [20,21]. One means of characterizing the interactions between inorganic clusters and target biomolecules is through the use of theoretical methods based on density functional theory (DFT) [22].…”

Section: Introductionmentioning

confidence: 99%

A Theoretical Study of the Binding of [Re6Se8(OH)2(H2O)4] Rhenium Clusters to DNA Purine Base Guanine

Alvarado-Soto

Ramírez-Tagle

2015

Materials

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Hexanuclear rhenium complexes are promising candidates for use as antitumor drugs. However, to date, there has been no investigation into the nature of their binding to DNA. In this study, density functional theory (DFT) was used to examine the binding of [Re6Se8(OH)2(H2O)4] to the DNA purine base guanine. The geometrical structures of cluster-guanine adducts in water were modeled at the zero order regular approximation (ZORA)-PW91 level. Calculating the bond energies allowed us to compare the cis and trans forms of the cluster, and a possible manners of interaction between [Re6Se8(OH)2(H2O)3] clusters and DNA was obtained and explained.

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Pt and Ti Complexes Immobilized onto Mesoporous Silica Microspheres and Their Interaction with Molecules of Biological Interest

et al. 2017

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Mesoporous silica microspheres (MSMs) have been functionalized with triazole and pendant hydroxy moieties by a postsynthetic procedure. The functionalities have been prepared by a very efficient azide/alkyne click reaction with propargyl alcohol to yield the corresponding 1,2,3‐triazole. The subsequent reaction with cisplatin and titanocene as metallic precursors produces platinum and titanium complexes tethered onto the silica surface. The synthesized materials have been fully characterized by dynamic recrystallization kinetics (DRX), FTIR, N2 adsorption/desorption techniques, TEM, diffuse reflectance (DR) UV/Vis and 13C cross polarization/magic angle spinning (CP/MAS) NMR spectroscopy. In addition, the interaction of these materials with molecules of biological interest such as guanosine and bovine serum albumin has been studied by means of solid‐state voltammetry techniques. Drug‐release experiments in simulated body fluid show sustained release profiles for the platinum complexes.

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New Directions in the Fight against Cancer: From Metal Complexes to Nanostructured Materials

Cited by 5 publications

References 333 publications

Anti‐cancer Applications of Titanocene‐Functionalised Nanostructured Systems: An Insight into Cell Death Mechanisms

Anti‐cancer Applications of Titanocene‐Functionalised Nanostructured Systems: An Insight into Cell Death Mechanisms

A Theoretical Study of the Binding of [Re6Se8(OH)2(H2O)4] Rhenium Clusters to DNA Purine Base Guanine

Pt and Ti Complexes Immobilized onto Mesoporous Silica Microspheres and Their Interaction with Molecules of Biological Interest

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