New dimeric, trimeric and supramolecular organotin(IV) dithiocarboxylates: Synthesis, structural characterization and biocidal activities

Inhibition effects of novel organotin(IV) esters of (E)-4-oxo-4-((3-trifluoromethyl)phenyl)amino)but-2-enoic acid have been studied against bacterial, fungal, tumoral and insecticidal strains. The complexes have shown potency against all these strains and is attributed to the multiple interactive sites of the ligand that not only change the environment around tin but also can make interactions with DNA. The synthesized complexes were characterized by physical, spectral, analytical and multinuclear nmr ( 1 H, 13 C, 119 Sn) data. The X-ray structure analysis of the complex is reported.

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“…All these values are consistent with literature values for organotin-oxygen derivatives [21,22]. [4,23].…”

Section: Ir Spectroscopysupporting

confidence: 92%

Fluoro Substituted Monomeric and Uni-Dimensional Polymeric Organotin(IV) Esters of (E)-4-oxo-4-((3-trifluoromethyl)phenyl)amino)but-2-enoic acid; Synthesis, Characterization and Their In vitro Inhibitory Studies

Ur-Rehman

Hussain

Tahir

et al. 2012

J Inorg Organomet Polym

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“…Two main factors are responsible for this reduction in polarity; firstly because of the partial sharing of its positive charge with donor groups and secondly due to p-electrons delocalization within the whole chelating ring. As consequence, the lipophilic nature of the central Sn atom increases, which favors the permeation of the complexes through the lipid layer of the cell membrane [32]. Table 8 Bond distances (Å) and bond angles ( ) for compound 1 (molecule 1).…”

Section: Antibacterial Activitymentioning

confidence: 99%

New dimeric and supramolecular organotin(IV) complexes with a tridentate schiff base as potential biocidal agents

Shujah

Rehman

Muhammad

et al. 2011

Journal of Organometallic Chemistry

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“…The cytoplasmic membrane may be the possible target of action. This observation is further supported by high activities of the tributyltin(IV) derivatives, which alter the membrane fluidity Zia-ur-Rehman et al [25] and the organism dies due to extensive K þ leakage. In spite of the controversy around the toxicity of organotins toward higher species [26], it is possible that some of their complexes are not so hazardous.…”

Section: Biocidal Activitiesmentioning

confidence: 81%

Supramolecular organotin(IV) dithiocarboxylates as potential antimicrobial agents

Rehman

Muhammady

Shah

et al. 2012

Journal of Coordination Chemistry

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A series of tri-, chlorodi-, and diorganotin(IV) derivatives of 4-(2-methoxyphenyl)piperazine-1-carbodithioate (L) {R ¼ n-C 4 H 9 (1), C 6 H 11 (2), CH 3 (3) and C 6 H 5 (4)}, (n-C 4 H 9 ) 2 SnClL (5) and R 2 SnL 2 {R ¼ n-C 4 H 9 (6), C 2 H 5 (7), CH 3 (8)} have been synthesized by refluxing organotin(IV) chlorides with the ligand-salt in the appropriate molar ratio. Elemental analysis, Raman, IR, multinuclear NMR ( 1 H, 13 C and 119 Sn), mass spectroscopic, and single-crystal X-ray crystallographic studies were undertaken to elucidate the structures of the new compounds both in solution and in the solid state. The X-ray diffraction work reveals supramolecular structures for 4 and 6, with distorted trigonal-bipyramidal and distorted octahedral geometries around Sn, respectively. The ligand and several of the new compounds are good antimicrobial agents.

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New dimeric, trimeric and supramolecular organotin(IV) dithiocarboxylates: Synthesis, structural characterization and biocidal activities

Cited by 60 publications

References 21 publications

Fluoro Substituted Monomeric and Uni-Dimensional Polymeric Organotin(IV) Esters of (E)-4-oxo-4-((3-trifluoromethyl)phenyl)amino)but-2-enoic acid; Synthesis, Characterization and Their In vitro Inhibitory Studies

Fluoro Substituted Monomeric and Uni-Dimensional Polymeric Organotin(IV) Esters of (E)-4-oxo-4-((3-trifluoromethyl)phenyl)amino)but-2-enoic acid; Synthesis, Characterization and Their In vitro Inhibitory Studies

New dimeric and supramolecular organotin(IV) complexes with a tridentate schiff base as potential biocidal agents

Supramolecular organotin(IV) dithiocarboxylates as potential antimicrobial agents

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