New Diketopiperazines from a Marine-Derived Fungus Strain Aspergillus versicolor MF180151

Hu, Jiansen; Li, Z; Gao, Jianping; He, Hong; Dai, Huanqin; Xia, Xuekui; Liu, Cuihua; Zhang, Lixin; Song, Fuhang

doi:10.3390/md17050262

Cited by 32 publications

(23 citation statements)

References 40 publications

(45 reference statements)

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“…Compounds 82-84 showed strong cytotoxicity with IC50 of 1.7 and 2 µ M against K562 and mouse lymphoma cell line, respectively; similarly, compounds 91-95 also showed strong cytotoxic activity [35][36][37]. Compounds 85-89 showed antibacterial activity against Staphylococcus aureus with the MIC values of 6.25-12.5 µ g/mL [21]. The new compound 90 also showed stronger inhibition activity against α-glucosidase with IC50 value of 138 µ M [37].…”

Section: Piperazine Derivativesmentioning

confidence: 96%

“…Twenty-four novel alkaloid-bioactive compounds (25-48; Figure 2) have been reported from deep-sea fungi since 2013, out of which compounds 25-40 were isolated from Penicillium spp., and showed cytotoxic activities against BV2 cell (IC50 of 27-45 µ g/mL), brine shrimp (IC50 of 14.1 to 38.5 µ g/mL), SMMC-7721 (IC50 of 54.2 µ M), BEL-7402 ((IC50 of 17.5 µ M), and BEL-7402 (IC50 of 19.8 µ M) [19][20][21]. Compounds 41-46 were identified from Aspergillus spp., in which compounds 41 and 45-46 displayed antibiotic activity (MIC of 30 to 40 µ g/mL) against BCG, Candida albicans, Bacillus subtilis, Staphylococcus aureus, Pseudomonas aeruginosa, Bacillus cereus, Klebsiella pneumoniae, and Escherichia…”

Section: Nitrogen-containing Compoundsmentioning

confidence: 99%

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Deep-Sea Fungi Could Be the New Arsenal for Bioactive Molecules

Arifeen

Xue

et al. 2019

Marine Drugs

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Growing microbial resistance to existing drugs and the search for new natural products of pharmaceutical importance have forced researchers to investigate unexplored environments, such as extreme ecosystems. The deep-sea (>1000 m below water surface) has a variety of extreme environments, such as deep-sea sediments, hydrothermal vents, and deep-sea cold region, which are considered to be new arsenals of natural products. Organisms living in the extreme environments of the deep-sea encounter harsh conditions, such as high salinity, extreme pH, absence of sun light, low temperature and oxygen, high hydrostatic pressure, and low availability of growth nutrients. The production of secondary metabolites is one of the strategies these organisms use to survive in such harsh conditions. Fungi growing in such extreme environments produce unique secondary metabolites for defense and communication, some of which also have clinical significance. Despite being the producer of many important bioactive molecules, deep-sea fungi have not been explored thoroughly. Here, we made a brief review of the structure, biological activity, and distribution of secondary metabolites produced by deep-sea fungi in the last five years.

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Section: Piperazine Derivativesmentioning

confidence: 96%

Section: Nitrogen-containing Compoundsmentioning

confidence: 99%

Deep-Sea Fungi Could Be the New Arsenal for Bioactive Molecules

Arifeen

Xue

et al. 2019

Marine Drugs

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“…Six new diketopiperazines (1-3) and another known four compounds were isolated from the fermentation broth culture of the fungus, A. versicolor MF180151 (Bohai Sea, China). These compounds showed some levels of biological activity and only versicolorin B (5) and averufin (6) had inhibitory activity against MRSA [79].…”

Section: Invertebrate-associated Bacteria (Sponge Ascidian)mentioning

confidence: 99%

Antibiotics Development and the Potentials of Marine-Derived Compounds to Stem the Tide of Multidrug-Resistant Pathogenic Bacteria, Fungi, and Protozoa

et al. 2020

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As the search for new antibiotics continues, the resistance to known antimicrobial compounds continues to increase. Many researchers around the world, in response to antibiotics resistance, have continued to search for new antimicrobial compounds in different ecological niches such as the marine environment. Marine habitats are one of the known and promising sources for bioactive compounds with antimicrobial potentials against currently drug-resistant strains of pathogenic microorganisms. For more than a decade, numerous antimicrobial compounds have been discovered from marine environments, with many more antimicrobials still being discovered every year. So far, only very few compounds are in preclinical and clinical trials. Research in marine natural products has resulted in the isolation and identification of numerous diverse and novel chemical compounds with potency against even drug-resistant pathogens. Some of these compounds, which mainly came from marine bacteria and fungi, have been classified into alkaloids, lactones, phenols, quinones, tannins, terpenes, glycosides, halogenated, polyketides, xanthones, macrocycles, peptides, and fatty acids. All these are geared towards discovering and isolating unique compounds with therapeutic potential, especially against multidrug-resistant pathogenic microorganisms. In this review, we tried to summarize published articles from 2015 to 2019 on antimicrobial compounds isolated from marine sources, including some of their chemical structures and tests performed against drug-resistant pathogens.

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“…Six new enantiomeric diketopiperazines, (±)-7,8-epoxybrevianamide Q (70 and 71), (±)-8-hydroxy-brevianamide R (72 and 73), and (±)-8-epihydroxy-brevianamide R (74 and 75) ( Supplementary Fig. S7) were isolated from the marinederived fungus strain A. versicolor MF180151, which was recovered from a sediment sample collected from the Bohai Sea, China (Hu et al 2019). Another analogue, 9ξ-O-2(2,3dimethylbut-3-enyl) brevianamide Q (76), was obtained from the culture of A. versicolor, an endophytic fungus isolated from the marine brown alga Sargassum thunbergii (Miao et al 2012).…”

Section: Indole Diketopiperazine Alkaloids (Dkps)mentioning

confidence: 99%

Marine-derived fungi as a source of bioactive indole alkaloids with diversified structures

Meng

Sun

Zhao

et al. 2020

Mar Life Sci Technol

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Marine-derived fungi are well known as rich sources of bioactive natural products. Growing evidences indicated that indole alkaloids, isolated from a variety of marine-derived fungi, have attracted considerable attention for their diverse, challenging structural complexity and promising bioactivities, and therefore, indole alkaloids have potential to be pharmaceutical lead compounds. Systemic compilation of the relevant literature. In this review, we demonstrated a comprehensive overview of 431 new indole alkaloids from 21 genera of marine-derived fungi with an emphasis on their structures and bioactivities, covering literatures published during 1982-2019.

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New Diketopiperazines from a Marine-Derived Fungus Strain Aspergillus versicolor MF180151

Cited by 32 publications

References 40 publications

Deep-Sea Fungi Could Be the New Arsenal for Bioactive Molecules

Deep-Sea Fungi Could Be the New Arsenal for Bioactive Molecules

Antibiotics Development and the Potentials of Marine-Derived Compounds to Stem the Tide of Multidrug-Resistant Pathogenic Bacteria, Fungi, and Protozoa

Marine-derived fungi as a source of bioactive indole alkaloids with diversified structures

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