New Dihydropyrimidines as Antimicrobial Agents

Lal, Kundan; Paliwal, L. J.; Bagade, Mahendra B.

doi:10.1016/j.matpr.2017.06.026

Cited by 1 publication

(2 citation statements)

References 23 publications

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“…The diaryldihydropyrimidines scaffolds 90 a-g (Figure 15) were synthesized by Lal et al and analyzed for their antibacterial activities against several bacterial strains. [139] Compounds 90 c, 90 d, and 90 e in particular have demonstrated strong efficacy against all bacterial species (including P. vulgaris, S. aureus, and Klebsiella). Compounds 90 b (m-NO 2 ) and 90 f (Naphthalene) showed superior antibacterial activity compared to standard Streptomycin, suggesting potential future use in future treatments.…”

Section: Antibacterialsmentioning

confidence: 99%

“…The diaryldihydropyrimidines scaffolds 90 a – g (Figure 15) were synthesized by Lal et al . and analyzed for their antibacterial activities against several bacterial strains [139] . Compounds 90 c , 90 d , and 90 e in particular have demonstrated strong efficacy against all bacterial species (including P. vulgaris, S. aureus, and Klebsiella).…”

Section: Pharmacological Activitymentioning

confidence: 99%

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Naphthyl‐Based Chalcone Derivatives: A Multifaceted Player in Medicinal Chemistry

Mahesha,

Shetty

2024

ChemistrySelect

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Research has placed a great deal of emphasis on molecule development and discovery with substantial biological profiling in recent years. Despite the significant side effects, medicinal chemists have long strived to synthesize drug molecules with the highest level of therapeutic activity and the lowest possible level of toxicity. The naphthyl‐based chalcone derivatives have drawn attention due to their simple structures and wide range of pharmacological effects. The main focus of this review is to outline the biologically active molecules based on naphthyl moiety‐substituted chalcone derivatives developed over the years. A synopsis of pharmacological screening, including relevant structure‐activity relationships, action mechanisms, and possible therapeutic applications, is provided in this article. It is true that prospective hybrids combining the naphthyl moiety with different chalcone pharmacophores are needed to address drug resistance and improve specificity. Therefore, this review may be useful in the development and design of new, highly successful therapeutic drugs based on previously reported methodologies.

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Section: Antibacterialsmentioning

confidence: 99%

Section: Pharmacological Activitymentioning

confidence: 99%