New Device for Raman Difference Spectroscopy with Multichannel and Scanning Multichannel Detection

Deckert, Volker; Liebler, W.; Eck, Reinhard; Kiefer, W.

doi:10.1366/0003702971941584

Cited by 13 publications

(3 citation statements)

References 9 publications

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“…Altogether, a CCD camera is the perfect multichannel detector for Raman spectroscopy. Deckert et al suggested a single-beam layout for a RDS device applying a CCD camera . However, they did not fully consider the new 2D array capabilities of this versatile detector because their setup was lacking the important improvement of an imaging (single-stage) spectrograph.…”

Section: Resultsmentioning

confidence: 99%

“…Random drifts of the apparatus into the opposite side would result in the observation of too small shifts. One can clearly recognize the ambiguities introduced by serial, nonsimultaneous detection of Raman signals, which are intended to be used for RDS calculations. Hence, the presented RDS setup using a CCD detector and simultaneous detection of the two signals leads to a much improved performance compared to formerly reported RDS devices.…”

Section: Resultsmentioning

confidence: 99%

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Device for Raman Difference Spectroscopy

et al. 2007

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A new layout of a versatile Raman difference setup is presented. The new device combines the advantages of the rotating cell for exploitation of the resonance Raman enhancement and the high precision of Raman difference spectroscopy together with the multiplex advantages and very high quantum efficiency offered by a CCD detector. While Raman difference spectroscopy is the most accurate method for the detection of very small band shifts, the method requires the strict prevention of any environmental perturbation of one of the two spectra, which are used for the difference spectra calculation. The presented device satisfies this requirement by implementing a double-beam layout, where the simultaneously detected Raman signals of two sample cells are combined within a Y-fiber bundle and imaged together onto the CCD detector. The accuracy of the new apparatus in detecting frequency shifts and minor sample components is greatly increased compared to conventional Raman spectroscopy as shown by studying binary mixtures of CHCl3 and CCl4. Hereby it was possible to resolve a formerly undetected shift of <0.02 cm(-1) of the CCl4 band at 218 cm(-1). The new RDS setup has a very versatile design. The device can take advantage of the high sensitivity and selectivity of the resonance Raman enhancement applying excitation wavelengths from the UV to NIR and can be used for a variety of samples with only minor changes in the optical arrangement. The new device will be of utmost importance for a fast, gentle, sensitive, selective, and precise investigation of biomolecules and their interactions. Some first results are shown concerning the interaction of the antimalarial chloroquine with hematin in a hydrous environment.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Device for Raman Difference Spectroscopy

et al. 2007

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“…4 A rotating, divided cell has been used to enable beams from two different samples to be recorded alternately on a charge-coupled device (CCD) detector. 5 In both of these experiments the technique was used for Raman difference spectroscopy. The simultaneous recording of different Raman spectra on to a CCD detector was advanced when it was demonstrated that multiple spectra could be recorded at different positions on a two-dimensional CCD.…”

Section: Introductionmentioning

confidence: 99%

Raman spectroscopy with simultaneous measurement of two orthogonally polarized Raman spectra

Thomson¹,

Baldwin²,

Batchelder³

2003

J Raman Spectroscopy

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A Raman microscope was modified to allow the independent acquisition of two orthogonally polarized components of a Raman spectrum in a single measurement. Preliminary performance was demonstrated by simultaneously measuring the intensity of both polarized components of the silicon Raman band at 520 cm −1 as a silicon wafer was rotated through 360 • under a polarized laser Raman probe. Polarizationresolved Raman spectra of a complex molecular crystal are also presented, illustrating the increase in spectral information available with the modified system.

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