New Developments in the Staging of Melanoma

Baruch, Amy C.; Shi, Jiaqi; Feng, Yongmei; Nelson, Mark A.

doi:10.1080/07357900500202887

Cited by 7 publications

(2 citation statements)

References 60 publications

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“…Development of malignant melanoma in humans, with the exception of nodular-type melanoma, consists of a series of sequential alterations in the evolving tumor cells (Jiang et al, 1994a;Herlyn et al, 2000;Leszczyniecka et al, 2001;Baruch et al, 2005). These include conversion of a normal melanocyte to a nevus, followed by development of a dysplastic nevus, a radial growth phase (RGP) primary melanoma, a vertical growth phase (VGP) primary melanoma, and ultimately a metastatic melanoma.…”

Section: Melanoma Differentiation Associated Gene-7/interleukin-24 Anmentioning

confidence: 99%

mda-7/IL-24: Multifunctional cancer-specific apoptosis-inducing cytokine

Gupta

Lebedeva

et al. 2006

Pharmacology & Therapeutics

157

247

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"Differentiation therapy" provides a unique and potentially effective, less toxic treatment paradigm for cancer. Moreover, combining "differentiation therapy" with molecular approaches presents an unparalleled opportunity to identify and clone genes mediating cancer growth control, differentiation, senescence, and programmed cell death (apoptosis). Subtraction hybridization applied to human melanoma cells induced to terminally differentiate by treatment with fibroblast interferon (IFN-beta) plus mezerein (MEZ) permitted cloning of melanoma differentiation associated (mda) genes. Founded on its novel properties, one particular mda gene, mda-7, now classified as a member of the interleukin (IL)-10 gene family (IL-24) because of conserved structure, chromosomal location, and cytokine-like properties has become the focus of attention of multiple laboratories. When administered by transfection or adenovirus-transduction into a spectrum of tumor cell types, melanoma differentiation associated gene-7/interleukin-24 (mda-7/IL-24) induces apoptosis, whereas no toxicity is apparent in normal cells. mda-7/IL-24 displays potent "bystander antitumor" activity and also has the capacity to enhance radiation lethality, to induce immune-regulatory activities, and to inhibit tumor angiogenesis. Based on these remarkable attributes and effective antitumor therapy in animal models, this cytokine has taken the important step of entering the clinic. In a Phase I clinical trial, intratumoral injections of adenovirus-administered mda-7/IL-24 (Ad.mda-7) was safe, elicited tumor-regulatory and immune-activating processes, and provided clinically significant activity. This review highlights our current understanding of the diverse activities and properties of this novel cytokine, with potential to become a prominent gene therapy for cancer.

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Section: Melanoma Differentiation Associated Gene-7/interleukin-24 Anmentioning

confidence: 99%

mda-7/IL-24: Multifunctional cancer-specific apoptosis-inducing cytokine

Gupta

Lebedeva

et al. 2006

Pharmacology & Therapeutics

157

247

View full text Add to dashboard Cite

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“…The melanoma patient's prognosis is currently based on the thickness of the primary tumor, presence or absence of tumor cells within regional lymph nodes and existence of metastases (Baruch, 2005). Therefore, the search is on for more consistent and reliable molecular markers that can identify and classify the melanoma and its severity.…”

Section: Melanoma and Melanocytesmentioning

confidence: 99%

DNA Microarrays in Dermatology and Skin Biology

Blumenberg

2006

OMICS: A Journal of Integrative Biology

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Because of its accessibility, skin has been among the first organs analyzed using DNA microarrays. Skin cancers, melanomas, and basal and squamous cell carcinomas have been intensely investigated because they are very frequent and can be fatal. Psoriasis, one of the most common human inflammatory diseases, has been studied comprehensively using DNA microarrays. In addition, epidermal keratinocytes have been the target of many studies because they respond to a rich variety of inflammatory and immunomodulating cytokines, hormones, vitamins, ultraviolet (UV) light, toxins, and physical injury. Because of the ethical considerations, the effects of harmful or dangerous agents on skin have been studied using artificial skin substitutes. Transcriptional mechanisms that regulate epidermal differentiation and cornification have begun to yield their mysteries, and very exciting recent studies identified the genes specifically expressed in epidermal stem cells. Thus, skin has everything: stem cells, differentiation, signaling, inflammation, diseases, and cancer. All these exciting facets of skin have been explored using DNA microarrays. Researchers in skin biology and dermatology were among the first to implement this technology and we expect that they will continue to generate exciting and useful new knowledge.

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Bibliography

2008

Phenotypic and Genotypic Diagnosis of Malignancies

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New Developments in the Staging of Melanoma

Cited by 7 publications

References 60 publications

mda-7/IL-24: Multifunctional cancer-specific apoptosis-inducing cytokine

mda-7/IL-24: Multifunctional cancer-specific apoptosis-inducing cytokine

DNA Microarrays in Dermatology and Skin Biology

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