New developments in scanning laser polarimetry for glaucoma

Lemij, Hans G; Reus, Nicolaas J.

doi:10.1097/icu.0b013e3282f4b1c2

Cited by 20 publications

(11 citation statements)

References 31 publications

(53 reference statements)

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“…In glaucoma, several imaging devices are used to analyze the peripapillary RNFL thickness, 4,[18][19][20][21][22] and the reproducibility of the measurements is very important for diagnosis of the disease and monitoring of its progression. Several previous studies using Stratus OCT have addressed the reproducibility of RNFL thickness measurements in normal and glaucomatous eyes.…”

Section: Discussionmentioning

confidence: 99%

Reproducibility of peripapillary retinal nerve fiber layer thickness with spectral domain cirrus high-definition optical coherence tomography in normal eyes

et al. 2010

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Section: Discussionmentioning

confidence: 99%

Reproducibility of peripapillary retinal nerve fiber layer thickness with spectral domain cirrus high-definition optical coherence tomography in normal eyes

et al. 2010

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“…SLP devices compensate for the effect of this anterior segment birefringence with a special technique; in earlier devices with a fixed corneal compensator (FCC) and since 2002 using variable corneal compensation (VCC) as in current models like the GDx VCC (Carl Zeiss Meditec, Jena, Germany). The latest method, called enhanced corneal compensation (ECC), is said to have further improved the evaluation of the RNFL by the SLP device and, according to recent studies [4, 5] has increased both the diagnostic accuracy and the correlation between functional and structural measurements. Recent research indicates that there is still a large gap between the diagnostic conclusions reached using these modern imaging devices and the clinical assessment: a study of 312 glaucoma patients and 41 control participants by Pablo et al ., [6] found that the agreement between the stereophotographic evaluations and the conclusions based on SLT and SLP was just 52.9%.…”

Section: Introductionmentioning

confidence: 99%

“…Whenever the observer of these images tries to assess whether obvious changes have occurred which may be interpreted as a sign of glaucomatous damage, it should be kept in mind that SLT does not measure the thickness of the retinal nerve fiber layer directly but rather puts its three-dimensional data in relation to a predetermined reference level. The measurements of both methods correlate with visual field loss in glaucoma patients [4, 8, 10, 11]. …”

Section: Introductionmentioning

confidence: 99%

Scanning Laser Topography and Scanning Laser Polarimetry: Comparing Both Imaging Methods at Same Distances from the Optic Nerve Head

Keienburg¹,

Anastassiou²,

Schallenberg³

et al. 2012

TOOPHTJ

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Purpose:To compare the performance of scanning laser topography (SLT) and scanning laser polarimetry (SLP) on the rim of the optic nerve head and its surrounding area and thereby to evaluate whether these imaging technologies are influenced by other factors beyond the thickness of the retinal nerve fiber layer (RNFL).Materials and Methodology:A total of 154 eyes from 5 different groups were examined: young healthy subjects (YNorm), old healthy subjects (ONorm), patients with normal tension glaucoma (NTG), patients with open-angle glaucoma and early glaucomatous damage (OAGE) and patients with open-angle glaucoma and advanced glaucomatous damage (OAGA). SLT and SLP measurements were taken. Four concentric circles were superimposed on each of the images: the first one measuring at the rim of the optic nerve head (1.0 ONHD), the next measuring at 1.25 optic nerve head diameters (ONHD), at 1.5 ONHD and at 1.75 ONHD. The aligned images were analyzed using GDx/NFA software.Results:Both methods showed peaks of RNFL thickness in the superior and inferior segments of the ONH. The maximum thickness, registered by the SLT device was at the ONH rim where the SLP device tended to measure the lowest values. SLT measurements at the ONH were influenced by other tissues besides the RNFL like blood vessels and glial tissues. SLT and SLP were most strongly correlated at distances of 1.25 and 1.5 ONHD.Conclusions:While both imaging technologies are valuable tools in detecting glaucoma, measurements at the ONH rim should be interpreted critically since both methods might provide misleading results. For the assessment of the retinal nerve fiber layer we would like to recommend for both imaging technologies, SLT and SLP, measurements in 1.25 and 1.5 ONHD distance of the rim of the optic nerve head.

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“…For example, the commercially available technology of scanning laser polarimetry uses retardation by RNFL birefringence as a measure of RNFL integrity [4]. The optical properties of the RNFL depend on axonal structure at the submicroscopic level; its birefringence, for example, arises from parallel intracellular fibrils called microtubules [5–8].…”

Section: Introductionmentioning

confidence: 99%

Dual-band spectral-domain optical coherence tomography for in vivo imaging the spectral contrasts of the retinal nerve fiber layer

Zhang¹,

Hu²,

Knighton³

et al. 2011

Opt. Express

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The ultimate goal of the study is to provide an imaging tool to detect the earliest signs of glaucoma before clinically visible damage occurs to the retinal nerve fiber layer (RNFL). Studies have shown that the optical reflectance of the damaged RNFL at short wavelength (<560nm) is reduced much more than that at long wavelength, which provides spectral contrast for imaging the earliest damage to the RNFL. To image the spectral contrast we built a dual-band spectral-domain optical coherence tomography (SD-OCT) centered at 808nm (NIR) and 415nm (VIS). The light at the two bands was provided by the fundamental and frequency-doubled outputs of a broadband Ti:Sapphire laser. The depth resolution of the NIR and VIS OCT systems are 4.7µm and 12.2µm in the air, respectively. The system was applied to imaging the rat retina in vivo. Significantly different appearances between the OCT cross sectional images at the two bands were observed. The ratio of the light reflected from the RNFL over that reflected from the entire retina at the two bands were quantitatively compared. The experimental results showed that the dual-band OCT system is feasible for imaging the spectral contrasts of the RNFL.

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New developments in scanning laser polarimetry for glaucoma

Abstract: With enhanced corneal compensation, the diagnostic accuracy of scanning laser polarimetry has been further improved for glaucoma. Newly developed algorithms for detecting any progressive retinal nerve fiber layer thinning await clinical validation.

Cited by 20 publications

References 31 publications

Reproducibility of peripapillary retinal nerve fiber layer thickness with spectral domain cirrus high-definition optical coherence tomography in normal eyes

Reproducibility of peripapillary retinal nerve fiber layer thickness with spectral domain cirrus high-definition optical coherence tomography in normal eyes

Scanning Laser Topography and Scanning Laser Polarimetry: Comparing Both Imaging Methods at Same Distances from the Optic Nerve Head

Dual-band spectral-domain optical coherence tomography for in vivo imaging the spectral contrasts of the retinal nerve fiber layer

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