New developments in non-Hodgkin lymphoid malignancies

Ganapathi, Karthik A.; Brown, Laura; Prakash, Sonam; Bhargava, Parul

doi:10.1016/j.pathol.2021.01.002

Cited by 19 publications

(18 citation statements)

References 146 publications

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“…Sjogren syndrome was associated with a extremely higher risk of developing marginal zone lymphoma and DLBCL, and Systemic lupus erythematosus was associated with a 2.7-fold increased risk of DLBCL and marginal zone lymphomas (Ekstrom et al 2008). Enteropathy-associated T-cell lymphoma, type II, is known to be associated with coeliac disease (Ganapathi et al 2021). In Japan, researchers found that patients with rheumatoid arthritis(RA) treated with methotrexate or other disease-modifying antirheumatic drugs carries a risk of lymphoproliferative disorders (Kurita et al 2019, Harada et al 2021).…”

Section: Discussionmentioning

confidence: 99%

Incidence, prognostic factors and clinical practice of Primary Pulmonary Lymphoma: A large population-based retrospective study

Tao

Zou

2022

Preprint

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Purpose: Primary pulmonary lymphoma(PPL) is a rare disease entity of pulmonary malignancies. The purpose of this study was to learn learn the incidence, treatment and survival of PPL.Methods: The incidence trend of PPL was investigated using Joinpoint regression software provided by National Cancer Institute. Cox regression analysis was performed to identify prognostic factors related to overall survival(OS) and disease-specific survival(DSS). The Kaplan-Meier method and log-rank test were used to evaluate OS and DSS.Results: A total of 1500 PPL patients were included in this study. The incidence of PPL was steadily increasing by annual percentage change(APC) of 2.7%(95%CI 2.0-3.4, P＜0.001). The median age was 66.0(19.0-99.0) years old along with more female(54.4%) patients than male. The most common subtype of PPL was marginal zone lymphoma of mucosa-associated lymphoid tissue(MALT)(41.3%) and diffuse large b-cell lymphoma(DLBCL)(29.7%), and the treatment regimens vary between these two subtype. Age, primary site, surgery, radiation, chemotherapy and laterality were identified as independent prognostic factors. Nomograms constructed for PPL-MALT and PPL-DLBCL to predict 1-, 5-, and 10-year OS and DSS. The area under curve (AUC) and calibration curves exhibit robust and accurate performance.Conclusions: Although rarely diagnosed, the incidence of PPL was steadily increasing in the past four decades. Nomograms for MALT and DLBCL in predicting 1-, 5-, 10-year OS and DSS were reliable. A diagram was drawn to describe PPL-MALT and PPL-DLBCL clinical practice.

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Section: Discussionmentioning

confidence: 99%

Incidence, prognostic factors and clinical practice of Primary Pulmonary Lymphoma: A large population-based retrospective study

Tao

Zou

2022

Preprint

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“…Since BLL-11q was named, cases have been reported continuously, but analysis has mainly been based on individual cases or minor cases, and the data on incidence rate and clinical manifestations are very limited. The age at onset of the tumor ranges widely from 2 to 83 years, but it is more common in young patients[ 2 , 8 ]. In children and adolescents under the age of 18 years, patients with BLL-11q have a median age of 13.9 years, relatively older than those with BL, high-grade B-cell lymphoma (HGBCL) and diffuse large B-cell lymphoma (DLBCL)[ 2 ].…”

Section: Discussionmentioning

confidence: 99%

“…Clinical Ann Arbor stages are mostly stage I/II, and less frequently stage III/IV[ 2 , 3 ]. The bone marrow and hydrocephalus are rarely involved[ 8 ]. In addition to those with normal immune function, BLL-11q in patients with HIV infection, organ transplantation, and immunosuppression have been reported[ 10 , 12 - 14 ].…”

Section: Discussionmentioning

confidence: 99%

“…Morphologically, tumor cells mainly grow diffusely, similar to BL, or between BL and DLBCL. They may have a certain degree of cell pleomorphism, and are occasionally nodular[ 1 , 3 , 8 ]. Horn et al [ 5 ] first proposed that when tissue cells phagocytize 5-9 apoptotic debris and apoptotic fragments with coarser particles, it is speculated that the specificity for 11q abnormality is 91% and the sensitivity is 85%.…”

Section: Discussionmentioning

confidence: 99%

“…They suggest BLL-11q as a distinct entity from BL. The sequence of molecular detection is to first detect MYC gene rearrangement, and then 11q chromosome detection when MYC gene rearrangement is negative, 11q proximal acquisition and distal deletion are required at the same time[ 1 , 8 , 9 , 13 ]. Only by combining morphology, immunophenotype and molecular biology can the correct diagnosis be made.…”

Section: Discussionmentioning

confidence: 99%

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Burkitt-like lymphoma with 11q aberration confirmed by needle biopsy of the liver: A case report

Yang¹,

Wang²

2022

WJCC

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BACKGROUND Burkitt-like lymphoma with 11q aberration (BLL-11q) is a rare provisional lymphoma, and the majority of cases are usually diagnosed by excisional lymph node biopsy. Here we report a case of BLL-11q diagnosed by needle biopsy of the liver in order to improve further understanding of the disease, reduce misdiagnosis, and identify treatment regimens. CASE SUMMARY The patient was a 67-year-old male. He complained of increased frequency of stools for more than one year, periumbilical pain and discomfort exceeding 3 mo. A computed tomography scan suggested an appendiceal malignant tumor with multiple metastases of the peritoneum, omentum, and liver. Needle biopsy of liver nodules showed that the tumor cells were of median size, the shape was consistent, a small number of tumor cells were large, the “starry sky” pattern was evident, and some tissue cells showed multiple apoptotic debris with coarse particles. Immunohistochemistry was positive for CD20, CD10, BCL6, and MYC. The Ki-67 proliferation index was more than 95%. Molecular biological detection indicated a lack of MYC , BCL2 and BCL6 gene rearrangement with 11q aberration. Therefore, the diagnosis was BLL-11q of the liver. After eight courses of chemotherapy, the abdominal and pelvic peritoneal masses and liver nodules had almost disappeared. The patient recovered well after a follow-up period of more than 13 mo. CONCLUSION BLL-11q is rare, but patients treated with standard chemotherapy for Burkitt lymphoma can have a good prognosis. Reducing the dose of chemotherapy or developing specific therapies to prevent overtreatment may be considered, but more case studies are needed.

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Updates on Molecular Pathogenesis of Non-Hodgkin’s Lymphoma

Abolhassani

2023

Interdisciplinary Cancer Research

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New developments in non-Hodgkin lymphoid malignancies

Cited by 19 publications

References 146 publications

Incidence, prognostic factors and clinical practice of Primary Pulmonary Lymphoma: A large population-based retrospective study

Incidence, prognostic factors and clinical practice of Primary Pulmonary Lymphoma: A large population-based retrospective study

Burkitt-like lymphoma with 11q aberration confirmed by needle biopsy of the liver: A case report

Updates on Molecular Pathogenesis of Non-Hodgkin’s Lymphoma

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