New development on hysteroscopy for endometrial cancer diagnosis: state of the art

Carugno, Josè; Marbin, Staci; Laganà, Antonio Simone; Vitale, Salvatore; Alonso, Luis; Sardo, Attilio Di Spiezio; Haimovich, Sergio

doi:10.23736/s0026-4806.20.07123-2

Cited by 19 publications

(12 citation statements)

References 62 publications

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“…Last but not least, hysteroscopy may be a useful instrument for undertaking endometrial tissue sampling under visual control (e.g., sampling the areas in which CE is suspected) [ 51 , 52 ]. Nevertheless, although the use of hysteroscopy with direct biopsies is consolidated in the approach to focal endometrial lesions [ 53 , 54 , 55 ], its effectiveness has still not been evaluated for CE.…”

Section: Discussionmentioning

confidence: 99%

Chronic Endometritis in Infertile Women: Impact of Untreated Disease, Plasma Cell Count and Antibiotic Therapy on IVF Outcome—A Systematic Review and Meta-Analysis

et al. 2022

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This systematic review and meta-analysis aims to evaluate the impact of chronic endometritis (CE) and its therapy on in vitro fertilization (IVF) outcome. Additionally, we aim to investigate whether various degrees of CE severity may exert a different effect on IVF outcome. Ongoing-pregnancy rate/live-birth-rate (OPR/LBR), clinical-pregnancy rate (CPR), and miscarriage rate (MR) were calculated. A total number of 4145 patients (from ten studies) were included. Women with CE had lower OPR/LBR (OR 1.97, p = 0.02) and CPR (OR 2.28, p = 0.002) compared to those without CE. CE cure increased OPR/LBR (OR 5.33, p < 0.0001) and CPR (OR 3.64, p = 0.0001). IVF outcome was comparable between women with cured CE and those without CE (OPR/LBR, CPR and MR: p = ns). Women with severe CE had lower OPR/LBR (OR 0.43, p = 0.003) and CPR (OR 0.40, p = 0.0007) compared to those mild CE. Mild CE showed no influence on the IVF outcome as compared to women without CE (OPR/LBR, CPR and MR: p = ns). Based on this data analysis, CE significantly reduces OPR/LBR and CPR in women undergoing IVF. Importantly, CE resolution after antibiotic therapy may improves IVF outcome, leading to similar OPR/LBR and CPR as compared to unaffected patients. The negative effects of CE on IVF outcome may be restricted to severe disease, whereas mild CE may have no influence on IVF success.

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Section: Discussionmentioning

confidence: 99%

Chronic Endometritis in Infertile Women: Impact of Untreated Disease, Plasma Cell Count and Antibiotic Therapy on IVF Outcome—A Systematic Review and Meta-Analysis

et al. 2022

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“…These studies support that AH/EIN are considered precursor or premalignant tumors specifically for endometrioid endometrial carcinomas (EEC) [ 250 , 254 , 260 ]. EEC accounts for >80% of all endometrial carcinomas and usually develop in premenopausal and peri-menopausal women, whereas serous uterine carcinomas account for <10% and are highly aggressive, estrogen-independent, and diagnosed mainly in postmenopausal women [ 249 , 261 , 262 , 263 , 264 , 265 ]. EEC are well known to be correlated with genetic alterations in PTEN , KRAS , CTNNB1, ARID1A, and PIK3CA [ 120 , 266 ].…”

Section: Endometrial Hyperplasia With or Without Atypiamentioning

confidence: 99%

Progesterone Actions and Resistance in Gynecological Disorders

MacLean

Hayashi

2022

Cells

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Estrogen and progesterone and their signaling mechanisms are tightly regulated to maintain a normal menstrual cycle and to support a successful pregnancy. The imbalance of estrogen and progesterone disrupts their complex regulatory mechanisms, leading to estrogen dominance and progesterone resistance. Gynecological diseases are heavily associated with dysregulated steroid hormones and can induce chronic pelvic pain, dysmenorrhea, dyspareunia, heavy bleeding, and infertility, which substantially impact the quality of women’s lives. Because the menstrual cycle repeatably occurs during reproductive ages with dynamic changes and remodeling of reproductive-related tissues, these alterations can accumulate and induce chronic and recurrent conditions. This review focuses on faulty progesterone signaling mechanisms and cellular responses to progesterone in endometriosis, adenomyosis, leiomyoma (uterine fibroids), polycystic ovary syndrome (PCOS), and endometrial hyperplasia. We also summarize the association with gene mutations and steroid hormone regulation in disease progression as well as current hormonal therapies and the clinical consequences of progesterone resistance.

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“…Endometrial hyperplastic processes are precursors to malignancy [31,32]. Adenocarcinoma is the most common endometrial carcinoma, accounting for more than 80 % of all endometrial carcinomas [33][34][35]. It is well known from the literature that endometrial cancer is correlated with genetic changes in PTEN, KRAS, CTNNB1, ARID1A and PIK3CA.…”

Section: Endometrial Hyperplasiamentioning

confidence: 99%

Endometrial hyperplasia and progesterone resistance: a complex relationship

Оразов

Mikhaleva

Mullina

2023

Vestn. Ross. univ. družby nar., Ser. Med.

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The endometrium is one of the most dynamic tissues that constantly undergoes changes during the menstrual cycle in women of the reproductive period. All these processes take place mainly under the influence of steroid hormones that are produced in the woman’s body. However, it is important to remember that throughout life the endometrial tissue undergoes changes under the influence of various factors that lead to imbalances in hormonal regulation. All these changes can lead to the development of endometrial hyperplasia, which has a high risk of both recurrence and malignization. Over the past few decades, the incidence of endometrial cancer has increased in many countries. This trend is thought to be related to the increasing prevalence of obesity, as well as to changing female reproductive patterns. Although there are currently no well-established screening programmers for endometrial cancer, endometrial hyperplasia is a recognized precursor, and its detection provides an opportunity for prevention. Studying the pathogenesis and risk factors will give a great advantage in the future to prevent possible complications. At this point, the activity and inhibition of the different hormone isoforms can lead to different hyperplastic processes. The management of patients depends on many factors: age, species, reproductive potential and other factors. Therefore, a comprehensive approach to treatment is always necessary. In recent years, interest in the study of endometrial hyperplasia has increased dramatically due to the increase in endometrial cancer. Therefore, the issue of early diagnosis and prevention is most urgent in modern gynecology and requires further study. This review reflects the current understanding of the disruption of progesterone signaling mechanisms in endometrial hyperplasia according to domestic and foreign literature.

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New development on hysteroscopy for endometrial cancer diagnosis: state of the art

Cited by 19 publications

References 62 publications

Chronic Endometritis in Infertile Women: Impact of Untreated Disease, Plasma Cell Count and Antibiotic Therapy on IVF Outcome—A Systematic Review and Meta-Analysis

Chronic Endometritis in Infertile Women: Impact of Untreated Disease, Plasma Cell Count and Antibiotic Therapy on IVF Outcome—A Systematic Review and Meta-Analysis

Progesterone Actions and Resistance in Gynecological Disorders

Endometrial hyperplasia and progesterone resistance: a complex relationship

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