New developed spectrophotometric method for simultaneous determination of salmeterol xinafoate and fluticasone propionate in bulk powder and Seritide® diskus inhalation

Computation of geometric representation of novel spectrophotometric methods used for the analysis of minor components in pharmaceutical preparations

“…This method could be applied for a mixture of X and Y with severely overlapping spectra, where X and Y shows large difference in their absorptivities, and hence no isoabsorptive point exists at the zero spectrum. So the absorptivity factor is calculated for X and Y (a X /a Y = F) [40,41].…”

Salmeterol Xinafoate

“…Absorbance of these sample solutions was recorded at 214 nm (λ max of salmeterol xinafoate) and 246 nm (λ max of fluticasone propionate) and concentrations of two drugs in the sample were determined by using simultaneous equations [35]. Abdelkawy et al [36] reported a new developed spectrophotometric method for simultaneous determination of salmeterol xinafoate and fluticasone propionate in bulk powder and inhalation dosage forms using UV-visible spectrophotometer, Shimadzu UV-1800, connected to an 40 20 0 ppm Figure 22 The DEPT 90 13 C NMR spectrum of salmeterol xinafoate in DMSO-d 6 .…”

Spectrophotometric methods for the simultaneous determination of paracetamol and dantrolene sodium in pharmaceutical dosage form

“…According to the ICH recommendations [22,23], the approach based on the S.D. of the response and the slope was used for determining the limit of detection and limit of quantification (Table 3).…”