New Dermatological Agents for the Treatment of Psoriasis

Fluorine in medicinal chemistry: A review of anti-cancer agents

“…For example, fidarestat 113 and sorbinil 114 (anti-cancer/anti-diabetic) [113], brequinar 115 (antitumour/ immunosuppressive) [114], roflumilast 116 (anti-inflammatory/ chronic obstructive pulmonary diseases) [115], leflunomide 117 and VML-295 (LY293111) 118 (anti-cancer/psoriasis) [116], T0901317 119 and 2,4,6-trisubstituted pyridines 120 have been reported as potent farnesoid X receptor (FXR) modulators and they have emerged as target drugs for inflammation and cancers [117]. Fluorinated gonadotropin-releasing hormone (hGnRH) receptor antagonists 121 and 122 are in clinical development for the treatment of human reproductive diseases and gynecological cancer [118] and the steroid sulfatase inhibitors 123, 124 have recently been reported as more potent compounds than their non-fluorinated analogues 125, 126 as inhibitors of steroid dependent cancers [119].…”

Stability Indicating RP-HPLC Method for Estimation of Impurities of Vitamin D<sub>3</sub> Analogue and Corticosteroid Used as Antipsoriatic Drugs. An Attempt to Characterize Pre-Calcipotriene

“…Psoriasis, a chronic inflammatory dermatosis characterized by scaling, infiltration, and erythema, affects approximately 2% of the worldwide population [1]. It is well-known that vitamin D 3 analogues, and Calci, are useful for the treatment of hyper proliferative skin diseases, such as psoriasis vulgaris [2]- [5].…”

Vitamin D3?Based Conjugates for Topical Treatment of Psoriasis: Synthesis, Antiproliferative Activity, and Cutaneous Penetration Studies

“…The solvent was evaporated under reduced pressure, and the residue was chromatographed on silica gel (eluting with 1% chloroform in methanol) to give the mono-and diester derivatives of the conjugates. 1 H NMR spectra were recorded on a Bruker DMX-500 operating at 500.1 MHz, and chemical shifts are reported in parts per million (␦) using TMS as the internal standard. Calcipotriol-PUFA mono conjugate: 1 …”

“…1 H NMR spectra were recorded on a Bruker DMX-500 operating at 500.1 MHz, and chemical shifts are reported in parts per million (␦) using TMS as the internal standard. Calcipotriol-PUFA mono conjugate: 1 …”

“…Psoriasis, a chronic inflammatory dermatosis characterized by scaling, infiltration, and erythema, affects approximately 2% of the worldwide population (1). The cause of psoriasis is unknown, but it is considered that disordered arachidonic acid metabolism may play a role in the pathogenesis of the disease through the chemotactic effect of the metabolites in human skin (2,3).…”