New derivatives of 11-keto-β-boswellic acid (KBA) induce apoptosis in breast and prostate cancers cells

Araba, Asma Bani; Rehman, Najeeb Ur; Al-Araimi, Amna; Al-Hashmi, Sulaiman; Al-Shidhani, Sulaiman; Csük, René; Hussain, Hidayat; Al‐Harrasi, Ahmed; Zadjali, Fahad

doi:10.1080/14786419.2019.1593165

Cited by 18 publications

(10 citation statements)

References 31 publications

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“…10,11 Recently, AKBA was also found to exhibit antitumor effects in human cell lines established from prostate cancer, breast cancer and glioblastoma. [12][13][14] Csuk et al demonstrated that boswellic acid and its derivatives induce apoptosis in breast and cervical cancers cells. 15 Liu indicated that AKBA inhibits the proliferation and cancer stem cell-like properties of docetaxel resistant prostate cancer cells in vitro and in vivo via blocking Akt and Stat3 signaling.…”

Section: Introductionmentioning

confidence: 99%

<p>Acetyl-11-keto-β-boswellic Acid Inhibits Precancerous Breast Lesion MCF-10AT Cells via Regulation of LINC00707/miR-206 that Reduces Estrogen Receptor-α</p>

Jiang¹,

Liu²,

Zhang³

et al. 2020

CMAR

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Acetyl-11-keto-β-boswellic acid (AKBA) has therapeutic effects on a range of diseases, including tumours. lncRNAs, as competing endogenous RNAs (ceRNAs), can interact with miRNAs to regulate the expression of target genes, which can affect the development of tumors. Here, we examined the effects of AKBA on breast precancerous lesions MCF-10AT cells. Methods: The expression profiles of breast cancer (BC) tissue were collated from The Cancer Genome Atlas (TCGA), and the lncRNA-miRNA-mRNA ceRNA network was constructed. AKBA targets were predicted by network pharmacology. The expression of long intergenic nonprotein-coding RNA 707 (LINC00707), miR-206 and ER-α was determined by qRT-PCR. Cell viability, apoptosis and cycle were assessed by CCK-8 and flow cytometry. Protein levels were measured by Western blotting. Results: A total of 3205 differentially expressed mRNAs, 104 miRNAs, and 605 lncRNAs were identified. The ceRNA network consisting of 9 lncRNAs, 15 miRNAs and 82 mRNAs was constructed. We found that LINC00707 was up-regulated and miR-206 was downregulated in MCF-10AT cells. Transfected si-LINC00707 could inhibit cell proliferation, induce cell apoptosis and cycle arrest of MCF-10AT cells. In addition, network pharmacology predicted that AKBA may regulate the ESR1 in the treatment of BC. Our research demonstrated that AKBA could induce cell apoptosis and G1-phase arrest and inhibit ER-α expression via LINC00707/miR-206 in MCF-10AT cells. Conclusion: AKBA inhibited MCF-10AT cells via regulation of LINC00707/miR-206 that reduces ER-α.

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Section: Introductionmentioning

confidence: 99%

<p>Acetyl-11-keto-β-boswellic Acid Inhibits Precancerous Breast Lesion MCF-10AT Cells via Regulation of LINC00707/miR-206 that Reduces Estrogen Receptor-α</p>

Jiang¹,

Liu²,

Zhang³

et al. 2020

CMAR

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“…In contrast, boscartin M, isoincensole oxide, incensole oxide, and incensole oxide acetate had a mild hepatoprotective effect at 10 μM [25]. In the other report by Wang et al, the investigation of B. sacra led to the isolation of ten new cembrane-type diterpenes, including boscartins AL-AU (25)(26)(27)(28)(29)(30)(31)(32)(33)(34) and five known analogs (35)(36)(37)(38)(39). Moreover, biological evaluations revealed that compounds 27, 29, 36, and 37 displayed hepatoprotective activities against paracetamol-induced HepG2 cell damage at 10 μM.…”

Section: Diterpenoidsmentioning

confidence: 97%

“…One of the important uses of BAs in medicine is as an anti-inflammatory. Boswellic acids suppress leukotriene biosynthesis in neutrophilic granulocytes by nonredox, noncompetitive inhibition of 5-lipoxygenase [32,[35][36][37]. e pharmacological effects of B. sacra extract are commonly explained by the presence of boswellic acids [36].…”

Section: Boswellic Acids Andmentioning

confidence: 99%

Taxonomical Investigation, Chemical Composition, Traditional Use in Medicine, and Pharmacological Activities of Boswellia sacra Flueck

Miran

Amirshahrokhi

Ajanii

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Aromatic oleo-gum-resin secreted from B. sacra, reputed as frankincense, is widely used in traditional medicine to treat Alzheimer’s disease, gastric disorders, hepatic disorders, etc. Frankincense is also used in the cosmetic, perfume, and beverage and food industries. Frankincense is a rich resource for bioactive compounds, especially boswellic acids and derivatives. Although several reports have described frankincense’s constituents and pharmacological activities, there is no comprehensive study that covers the valuable information on this species. Therefore, the current review will focus on the phytochemistry, traditional uses, and pharmacological activities of B. sacra.

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“…These aconitine alkaloids, including aconine, songorine and neoline, showed less toxicity but higher analgesic (Dong et al, 2015; Suzuki et al, 2016; Tanimura, Yoshida, Ishiuchi, Ohsawa, & Makino, 2019) and anti‐inflammatory activities (Qi et al, 2018; Wang et al, 2019; Zhang et al, 2015). KBA and AKBA, the representative pentacyclic triterpenic acid in Boszvellia carterii Birdw , showed strongly anti‐inflammatory (Bini Araba et al, 2019; Goel, Ahmad, Singh, & Singh, 2010; Ranzato et al, 2017) and anti‐tumour activities (Sayed & El Sayed, 2016; Takahashi et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Simultaneous determination of five bioactive components of XiaoJin Capsule in normal and mammary gland hyperplasia rat plasma using LC–MS/MS and its application to a pharmacokinetic study

Wang

et al. 2020

Biomedical Chromatography

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XiaoJin Capsule (XJC) is a classic Traditional Chinese Medicine formula for clinical treatment of thyroid nodules, mammary gland hyperplasia and breast cancer. For the specification and rational application of XJC in the future, an accurate and specific LC–MS/MS method was developed and validated for quantitative determination of five components in rat plasma after oral administration of XJC. The collected plasma samples were extracted by protein precipitation with methanol–acetonitrile (1:3, v/v) mixture solvent and separated on a C18 column using a gradient elution system. Mass spectrometry was performed on a triple quadrupole mass spectrometer, and samples were detected in positive ionization and multiple reactions monitoring mode. The method was properly validated in terms of linearity, precision, accuracy, recovery, matrix effect and stability. All calibration curves showed good linearity (r2 > 0.9910) over their concentration ranges. The intra‐ and inter‐day precisions (RSD) were within 11.0%, and the LLOQ was 0.1, 0.2, 0.5, 7.5 and 7.5 ng/ml for aconine, songorine, neoline, 3‐acetyl‐11‐keto‐β‐boswellic acid and 11‐keto‐β‐boswellic acid, respectively. Extraction recovery, matrix effect and stability were satisfactory in rat plasma. This established method was successfully applied to a pharmacokinetics study of five compounds after oral administration of XJC to normal and mammary gland hyperplasia model rats.

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New derivatives of 11-keto-β-boswellic acid (KBA) induce apoptosis in breast and prostate cancers cells

Cited by 18 publications

References 31 publications

<p>Acetyl-11-keto-β-boswellic Acid Inhibits Precancerous Breast Lesion MCF-10AT Cells via Regulation of LINC00707/miR-206 that Reduces Estrogen Receptor-α</p>

<p>Acetyl-11-keto-β-boswellic Acid Inhibits Precancerous Breast Lesion MCF-10AT Cells via Regulation of LINC00707/miR-206 that Reduces Estrogen Receptor-α</p>

Taxonomical Investigation, Chemical Composition, Traditional Use in Medicine, and Pharmacological Activities of Boswellia sacra Flueck

Simultaneous determination of five bioactive components of XiaoJin Capsule in normal and mammary gland hyperplasia rat plasma using LC–MS/MS and its application to a pharmacokinetic study

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