New Delhi metallo-β-lactamase and extended spectrum β-lactamases co-producing isolates are high in community-acquired urinary infections in Assam as detected by a novel multiplex polymerase chain reaction assay

Vv, Borah; Saikia, KK; Chandra, Prem; Hazarika, Naba Kumar; Chakravarty, Runu

doi:10.4103/0255-0857.176853

Cited by 17 publications

(15 citation statements)

References 17 publications

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“…41 Of great concern, they have also been recognized as a source of community-associated infections. 48 NDM producers have also been described in Enterobacteriaceae in China, but appear to be less widespread as compared to India. In a multicenter study looking at 90 patients with E. coli BSI in Shanghai between 2013-2014, no NDM producers were found.…”

Section: Where Are Cpe Found?mentioning

confidence: 99%

The global epidemiology of carbapenemase-producing Enterobacteriaceae

2016

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Carbapenemase-producing Enterobacteriaceae (CPE) are an important and increasing threat to global health. Both clonal spread and plasmid-mediated transmission contribute to the ongoing rise in incidence of these bacteria. Among the 4 classes of β-lactamases defined by the Ambler classification system, the carbapenemases that confer carbapenem resistance in Enterobacteriaceae belong to 3 of them: Class A (K. pneumoniae carbapenemases, KPC), Class B (metallo-β-lactamases, MBL including New Delhi metallo-β-lactamases, NDM) and Class D (OXA-48-like carbapenemases). KPC-producing CPE are the most commonly occurring CPE in the United States. MBL-producing CPE have been most commonly associated with the Indian Subcontinent as well as with specific countries in Europe, including Romania, Denmark, Spain, and Hungary. The epicenter of OXA-48-like-producing is in Turkey and surrounding countries. Detailed knowledge of the epidemiology and molecular characteristics of CPE is essential to stem the spread of these pathogens.

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Section: Where Are Cpe Found?mentioning

confidence: 99%

The global epidemiology of carbapenemase-producing Enterobacteriaceae

2016

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“…were resistant to carbapenems, aminoglycosides, fluoroquinolones and third-generation cephalosporins ( 70 ). Recently, some newer resistance mechanisms such as the metallo-beta-lactamase NDM-1 have also been witnessed ( 71 , 72 ). Such resistance mechanisms can further challenge efforts made toward management of AMR.…”

Section: Surveillance and Monitoringmentioning

confidence: 99%

Antimicrobial Resistance: Its Surveillance, Impact, and Alternative Management Strategies in Dairy Animals

et al. 2018

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Antimicrobial resistance (AMR), one among the most common priority areas identified by both national and international agencies, is mushrooming as a silent pandemic. The advancement in public health care through introduction of antibiotics against infectious agents is now being threatened by global development of multidrug-resistant strains. These strains are product of both continuous evolution and un-checked antimicrobial usage (AMU). Though antibiotic application in livestock has largely contributed toward health and productivity, it has also played significant role in evolution of resistant strains. Although, a significant emphasis has been given to AMR in humans, trends in animals, on other hand, are not much emphasized. Dairy farming involves surplus use of antibiotics as prophylactic and growth promoting agents. This non-therapeutic application of antibiotics, their dosage, and withdrawal period needs to be re-evaluated and rationally defined. A dairy animal also poses a serious risk of transmission of resistant strains to humans and environment. Outlining the scope of the problem is necessary for formulating and monitoring an active response to AMR. Effective and commendably connected surveillance programs at multidisciplinary level can contribute to better understand and minimize the emergence of resistance. Besides, it requires a renewed emphasis on investments into research for finding alternate, safe, cost effective, and innovative strategies, parallel to discovery of new antibiotics. Nevertheless, numerous direct or indirect novel approaches based on host–microbial interaction and molecular mechanisms of pathogens are also being developed and corroborated by researchers to combat the threat of resistance. This review places a concerted effort to club the current outline of AMU and AMR in dairy animals; ongoing global surveillance and monitoring programs; its impact at animal human interface; and strategies for combating resistance with an extensive overview on possible alternates to current day antibiotics that could be implemented in livestock sector.

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“…It is also seen almost exclusively in healthcare-associated infections, with the exception of the Indian subcontinent where community-associated CRE infections due to NDM-producing strains have been reported. 23 Countries known to have high overall rates of CRE include Greece, Italy, Brazil and China, followed by several other countries including the U.S. and Colombia. Countries in the Indian subcontinent have a high burden of CRE that is driven by the spread of NDM-producing strains, but prevalence data are scarce.…”

Section: Epidemiology Of Crementioning

confidence: 99%

Carbapenem-Resistant Enterobacteriaceae

Iovleva

Doi

2017

Clinics in Laboratory Medicine

185

146

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Synopsis Carbapenem-resistant Enterobacteriaceae (CRE) have emerged as a major threat to modern medicine. Commonly used antibiotics are generally inactive against CRE. Therefore, timely detection of CRE in the clinical laboratory is of paramount importance. Among CRE, those producing carbapenem-hydrolyzing β-lactamase enzymes (carbapenemase-producing Enterobacteriaceae; CPE) are particularly of concern since they tend to spread among patients, and treatment of active infection is difficult. The carbapenemase groups most commonly encountered include KPC, NDM and OXA-48, with KPC overrepresented in the United States. Various phenotypic and genetic tests have been proposed and validated for rapid detection of CPE. Phenotypic tests detect carbapenemase activity either by inhibiting their activity with specific inhibitors of carbapenemases, or by detecting hydrolysis of carbapenems by carbapenemases. Genetic tests mostly depend on nucleic acid detection and amplification. Treatment options for CRE infections are limited and typically include combinations of polymyxins, tigecycline, aminoglycosides, or carbapenems, but newer agents with activity against CRE and better safety profiles are starting to become available and will likely emerge as the preferred therapy for the treatment of CRE infections in the near future.

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New Delhi metallo-β-lactamase and extended spectrum β-lactamases co-producing isolates are high in community-acquired urinary infections in Assam as detected by a novel multiplex polymerase chain reaction assay

Cited by 17 publications

References 17 publications

The global epidemiology of carbapenemase-producing Enterobacteriaceae

The global epidemiology of carbapenemase-producing Enterobacteriaceae

Antimicrobial Resistance: Its Surveillance, Impact, and Alternative Management Strategies in Dairy Animals

Carbapenem-Resistant Enterobacteriaceae

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