New Data on the Regulation of Taurine Uptake in Cultured Nervous Cells

Rebel, G.; Petegnief, Valérie; Lleu, P.-L.; Gupta, Ramesh C.; Guérin, Paulette; Bourguignon, Jacques

doi:10.1007/978-1-4899-1471-2_23

Cited by 9 publications

(3 citation statements)

References 18 publications

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“…Taurine is found in highest concentrations in cardiac muscle, skeletal muscle, the CNS, and platelets. 1 Taurine is involved in numerous metabolic processes, including antioxidation, retinal photoreceptor activity, stabilization of neural membranes, development of the nervous system, reduction in platelet aggregation, [2][3][4][5][6][7] reproduction, 8 and conjugation of bile acids. 1,9 Taurine also has an important role related to myocardial function.…”

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confidence: 99%

Effects of dietary fat and L-carnitine on plasma and whole blood taurine concentrations and cardiac function in healthy dogs fed protein-restricted diets

Sanderson¹,

Gross²,

Ogburn³

et al. 2001

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Results revealed that dogs fed protein-restricted diets can develop decreased taurine concentrations; therefore, protein-restricted diets should be supplemented with taurine. Dietary methionine and cystine concentrations at or above AAFCO recommended minimum requirements did not prevent decreased taurine concentrations. The possibility exists that AAFCO recommended minimum requirements are not adequate for dogs consuming protein-restricted diets. Our results also revealed that, similar to cats, dogs can develop DCM secondary to taurine deficiency, and taurine supplementation can result in substantial improvement in cardiac function.

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confidence: 99%

Effects of dietary fat and L-carnitine on plasma and whole blood taurine concentrations and cardiac function in healthy dogs fed protein-restricted diets

Sanderson¹,

Gross²,

Ogburn³

et al. 2001

ajvr

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“…Taurine can alter the effect of KCN [165]. When KCN is given to rats, oxygen consumption decreasesd (31%) but i.p.…”

Section: Anti-cynide Actionmentioning

confidence: 96%

Taurine Analogues; A New Class of Therapeutics: Retrospect and Prospects

Gupta

Win

Bittner

2005

CMC

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Taurine was discovered more than two hundred years ago from animal sources. It is distributed in both mammals and non-mammals and its content is high in several tissues. For more than a century-and-a-half, taurine was regarded just as an end product of sulfur metabolism. Recently, taurine has been rediscovered and its beneficial effects in processes like epilepsy, hypertension, congestive heart failure and diabetes have been well-documented. It was patented and found some clinical utility, but being an amino acid, therapeutic use confronts limitations like restricted permeability and more. This necessitates the development of pro-drugs (analogues) mainly derivatives of taurine. A large number of taurine derivatives have been reported in the literature with partial to marked activity. Taurine derivatives like taltrimide, acamprosate and tauromustine, are already in the market as anti-convulsant, anti-alcoholic and anti-cancer agents. Many other analogues are effective in experimental models. The in depth analysis of these analogues and their biological actions can provide certain clues for further consideration. In the present review, attempts have been made to provide synopsis, synthesis and symbiosis of chemical and biological actions, which may provide future guidance and facilitate further research in this area. The successful journey of these analogues to clinical utility is a healthy and happy sign and an index of bright future, and we hope that this review will provide enough input to ignite the minds.

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“…The most potent inhibitors of cloned TAUTs are hypotaurine and b-alanine, (Kulanthaivel et al, 1991;Liu et al, 1992;Smith et al, 1992;Vinnakota et al, 1997), which also most efficiently inhibit taurine transport in brain slices (Lähdesmäki and Oja, 1973) and cultured cells (Holopainen et al, 1983;Rebel et al, 1994). The transporters also accept GABA, albeit with a much lesser affinity (Vinnakota et al, 1997).…”

Section: Uptakementioning

confidence: 99%

Handbook of Neurochemistry and Molecular Neurobiology

2008

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Additionally, the whole set will be available upon completion under The electronic version of the whole set will be available under The print and electronic bundle of the whole set will be available under ISBN: 978-0-387-35478-1 ß 2008 Springer Science+Business Media, LLC.All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Springer Science+Business Media, LLC., 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. springer.comPrinted on acid-free paper SPIN: 11416593 2109 -5 4 3 2 1 0 PrefaceThe brain is the organ that collects information from the environment, processes and stores the information, and generates behavior as and when needed. In essence, the brain makes us who we are. For this reason, understanding the biology of brain function is a great challenge and a major goal of modern science. The brain is one of the last great frontiers in science, and the unraveling of its mysteries is comparable in complexity to efforts in space exploration. Therefore, it was not a surprise that the U.S. Congress proclaimed the 1990s the ''Decade of the Brain,'' a movement also introduced by several other countries, thereby giving a chance for neuroscientists to focus on this topic and to have better conditions for their research.A fundamental goal of neuroscience is to understand how neurons generate behavior and the pathophysiology of different mental and neurological diseases. This requires, among other things, information about where these neurons are located, how they are connected, and how they communicate with each other in various physiological and pathophysiological conditions.At the end of the nineteenth century, the great neuroanatomist Santiago Ramon y Cajal recognized that neurons are the individual signaling elements of the brain. In this book, we focus on these nerve cells of the brain and the chemical molecules that allow them to talk to each other. The discovery of intercellular communication through endogenous molecules is a milestone in the history of science. It makes the brain a unique organ.Our aim is to describe recent discoveries about the basic operations of the brain and to provide an introduction to the adaptations for specific types of information processing. For example, at a chemical synapse, the presynaptic terminal liberates a transmitter substance that acts on the postsynaptic process. Thus, a synapse converts a presynaptic electrical signal into a chemical signal and back into a postsynaptic electrical signal.Cur...

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New Data on the Regulation of Taurine Uptake in Cultured Nervous Cells

Cited by 9 publications

References 18 publications

Effects of dietary fat and L-carnitine on plasma and whole blood taurine concentrations and cardiac function in healthy dogs fed protein-restricted diets

Effects of dietary fat and L-carnitine on plasma and whole blood taurine concentrations and cardiac function in healthy dogs fed protein-restricted diets

Taurine Analogues; A New Class of Therapeutics: Retrospect and Prospects

Handbook of Neurochemistry and Molecular Neurobiology

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